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ID:1126995
User:195.113.62.191
Article:Monoclonal antibodies
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The idea of a "[[Paul Ehrlich#"Magic Bullet"|magic bullet]]" was first proposed by [[Paul Ehrlich]], who, at the beginning of the 20th century, postulated that, if a compound could be made that selectively targeted against a disease-causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. He and [[Élie Metchnikoff]] received the 1908 Nobel Prize for Physiology or Medicine for this work, which led to an effective syphilis treatment by 1910.
 
The idea of a "[[Paul Ehrlich#"Magic Bullet"|magic bullet]]" was first proposed by [[Paul Ehrlich]], who, at the beginning of the 20th century, postulated that, if a compound could be made that selectively targeted against a disease-causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. He and [[Élie Metchnikoff]] received the 1908 Nobel Prize for Physiology or Medicine for this work, which led to an effective syphilis treatment by 1910.
   
In the 1970s, the B-cell cancer [[multiple myeloma]] was known, and it was understood that these cancerous B-cells all produce a single type of antibody (a [[paraprotein]]). This was used to study the structure of antibodies, but it was not yet possible to produce identical antibodies specific to a given [[antigen]].
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In the 1970s, the B-cell cancer [[multiple myeloma]] was known, and it was understood that these cancerous B-cells all produce a single type of antibody (a [[paraprotein]]). This was used to study the structure of antibodies, but it was not yet possible to produce identical antibodies specific to a given [[antigen]]. KON IS GAY
   
 
Production of monoclonal antibodies involving human–mouse hybrid cells was described by Jerrold Schwaber in 1973<ref>{{cite pmid|4200460}}</ref> and remains widely cited among those using human-derived [[hybridomas]],<ref>Science Citation Index</ref> but claims to priority have been controversial. A science history paper on the subject gave some credit to Schwaber for inventing a technique that was widely cited, but stopped short of suggesting that he had been cheated.<ref>{{cite doi|10.1007/BF00162840}}</ref> The invention was conceived by [http://lifesci.rutgers.edu/~molbiosci/faculty/pieczenik.html George Pieczenik], with John Sedat, [[Elizabeth Blackburn]]'s husband, as a witness and reduced to practice by Cotton and Milstein, and then by Kohler and Milstein. [[Georges J. F. Köhler|Georges Köhler]], [[César Milstein]], and [[Niels Kaj Jerne]] in 1975;<ref>{{cite doi|10.1038/256495a0}}</ref> who shared the [[Nobel Prize in Physiology or Medicine]] in 1984 for the discovery. The key idea was to use a line of myeloma cells that had lost their ability to secrete antibodies, come up with a technique to fuse these cells with healthy antibody-producing B-cells, and be able to select for the successfully fused cells.
 
Production of monoclonal antibodies involving human–mouse hybrid cells was described by Jerrold Schwaber in 1973<ref>{{cite pmid|4200460}}</ref> and remains widely cited among those using human-derived [[hybridomas]],<ref>Science Citation Index</ref> but claims to priority have been controversial. A science history paper on the subject gave some credit to Schwaber for inventing a technique that was widely cited, but stopped short of suggesting that he had been cheated.<ref>{{cite doi|10.1007/BF00162840}}</ref> The invention was conceived by [http://lifesci.rutgers.edu/~molbiosci/faculty/pieczenik.html George Pieczenik], with John Sedat, [[Elizabeth Blackburn]]'s husband, as a witness and reduced to practice by Cotton and Milstein, and then by Kohler and Milstein. [[Georges J. F. Köhler|Georges Köhler]], [[César Milstein]], and [[Niels Kaj Jerne]] in 1975;<ref>{{cite doi|10.1038/256495a0}}</ref> who shared the [[Nobel Prize in Physiology or Medicine]] in 1984 for the discovery. The key idea was to use a line of myeloma cells that had lost their ability to secrete antibodies, come up with a technique to fuse these cells with healthy antibody-producing B-cells, and be able to select for the successfully fused cells.
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