A reckless young mouse named Ralph makes friends with a boy in room 215 of the Mountain View Inn and discovers the joys of motorcycling.

"Big sister Beezus Quimby tries to be patient with her ltitle sister, Ramona, but it isn't easy, not when Ramona powders her nose with marshmellows and invites her nursery school classmates to Beezus's birthday party without telling her family. Sometimes Beezus doesn't like Ramona, but the girls are sisters and that means they will always love each other...just not every single minute."--Page 4 of cover.

Follows the adventures of nine-year-old Ramona at home, with big sister Beezus and baby sister Roberta, and at school in Mrs. Meacham's class.

Presents the further adventures of a motorcycle-riding mouse who goes to school and becomes the instigator of an investigation of rodents and the peacemaker for two lonely boys.

Ramona's year in third grade is highlighted by the arrival of Howie's rich Uncle Hobart, a change in her after-school situation, a surprise wedding, a death and a new arrival in the family, and her father's getting a job.

In a series of diary entries, Leigh tells how he comes to terms with his parents' divorce, acquires joint custody of an abandoned dog, and joins the track team at school.

Jimmy and Janet, four-year-old twins, share the adventures of digging a hole to China, finding a worthy recipient for their dog biscuits, shopping for new shoes, and getting real beds to replace their cribs.

Henry and his friends build a clubhouse, and trouble ensues when they exclude Ramona and Beezus, who try to sneak in.

Ramona meets lots of interesting people in kindergarten class, like Davy whom she keeps trying to kiss and Susan whose springy curls seem to ask to be pulled.

It seems too good to be true. The most popular boy in school has asked Jane out -- and she's never even dated before. Stan is tall and good-looking, friendly and hard-working -- everything Jane ever dreamed of. But is she ready for this? Suppose her parents won't let her go? What if she's nervous and makes a fool of herself? Maybe he'll think she's too young. If only she knew all the clever things to say. If only she were prettier. If only she were...