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1. Importance of Full-Collapse Vesicle Exocytosis for Synaptic Fatigue-Resistance at Rat Fast and... 2018

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZoJSQuqBQEoWXlSnBMdxsnfhxp1RWttAK1gLhF40fKoiZZNYlgr_xyxk6y2kWcOMSH-CHLM-P5xh7PEPJWaR9i02bxTAmIUw5nsQKbxNxCgdrZZSakTtg6zCHZ-BYmOO0bvTyt7svTavk9-FauSjMd_cSmnxYXHPlSsGy6R_YES0cTfbCyGAL63sOdoT0_Xf4oG1R6AoGKT1fEwhWmTx67pYZCtP5_Qcy_PSW3VM_8gDwdMCN938_tGXnkqkPyuM8iuX5Ofl-VAUQj-WhdUG9Uxv48AFaNo19d4zvRy1-1Wbd1s2wowlR6u64ANwtD50iZu87FN9iu6ceAlt7gN4empVBZentf_6SLrvHDhFgeZdd7r9JrVIqBb1-QL_PLzxcf4iG1QmxSIdsYJdVZZjkXiZPKQKJnHJGcMNIUBgyXRmWZnSmjNTiJ9JJGclekGpRKM83ZK0KZVWe4OWapRatGGwZG2gIHtAlisLSQEXk3LnG-6kNn5GhyeKrk21SJyLlf_00bH_A6_Kgf7vKB7DniWNAs02CVTTlLISmUmxXMKAAHWkXkeKRePkhhk6M5q_y9rUgicrKpRvnxlyJQubrDNrjnJcxHCYzIy57Ym5mMzBIRscMGO1PdrUGWDTG6BxZ9_d89j8gTxGYyeAYnx2S_fejcG7LvH3ZMkO2_iVCeT8IhApaL5OMkCMIfADYPGQ

   Rudling, Jane E; Drever, Benjamin D; Reid, Brian; Bewick, Guy S

   International Journal Of Molecular Sciences, Vol. 19, Issue 7, p. 1936.

   Neurotransmitter release during trains of activity usually involves two vesicle pools (readily releasable pool, or RRP, and reserve pool, or RP) and two exocytosis mechanisms ("full-collapse" and "... Read more

   Neurotransmitter release during trains of activity usually involves two vesicle pools (readily releasable pool, or RRP, and reserve pool, or RP) and two exocytosis mechanisms ("full-collapse" and "kiss-and-run"). However, synaptic terminals are adapted to differing patterns of use and the relationship of these factors to enabling terminals to adapt to differing transmitter release demands is not clear. We have therefore tested their contribution to a terminal's ability to maintain release, or synaptic fatiguability in motor terminals innervating fast-twitch (fatiguable), and postural slow-twitch (fatigue-resistant) muscles. We used electrophysiological recording of neurotransmission and fluorescent dye markers of vesicle recycling to compare the effects of kinase inhibitors of varying myosin light chain kinase (MLCK) selectivity (staurosporine, wortmannin, LY294002 & ML-9) on vesicle pools, exocytosis mechanisms, and sustained neurotransmitter release, using postural-type activity train (20 Hz for 10 min) in these muscles. In both muscles, a small, rapidly depleted vesicle pool (the RRP) was inhibitor insensitive, continuing to release FM1-43, which is a marker of full-collapse exocytosis. MLCK-inhibiting kinases blocked all remaining FM1-43 loss from labelled vesicles. However, FM2-10 release only slowed, indicating continuing kiss-and-run exocytosis. Despite this, kinase inhibitors did not affect transmitter release fatiguability under normal conditions. However, augmenting release in high Ca entirely blocked the synaptic fatigue-resistance of terminals in slow-twitch muscles. Thus, full-collapse exocytosis from most vesicles (the RP) is not essential for maintaining release during a single prolonged train. However, it becomes critical in fatigue-resistant terminals during high vesicle demand. Read less

   Journal Article  |  Full Text Online

2. Very young leaders 2014

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07TwMxDLZouzCVAhLP0yGxRk0ur8uECqICqQMSFWKrcpfcBG0pdOi_J87dqWVAQmLPkNiOYzufPwNcmwIpNp0k1GhLhLKMGOsyopytwuvsZRlHJ-wUc2o0IfbCNPpt3WL01W5RYpl8mHFNDcWI_2b5QXBwFH6wNlM0OtBjSO6G6D36tC2zoEnHhriQbEgihMx_et2seUrGfXhvNxERJDi3YBdKP4z0hZGzoqVq_NeGD6Dfckino9pKBrDn54c4r7nBdhzB4MWvNukGb376VoObj2E6vp_ePZBmWgJZKpURblnmCkU5tmUwI6zWPkRDljnKCplbJYsgfxkSOs9luHrW5Q7Z60qvFa2KnJ9Ayp1hwd1J4UKeUpTclrmrlM5cFqIqUeWncNWecxasEL8W7Nwv1p-zEAVwI3QQ-O9rttI4-8Oac9gPsYmokbEX0P1arf0ldFEbCXT0620CvdHkefKYRIV_A_Qkth4

   Green, Jane Bewick

   Conference & Common Room, Vol. 51, Issue 2, p. 11.

   The idea is eventually to host a competition day and invite other local schools to come and join in with a multi-skills, multi-sport event." For the moment, the Young Leaders at Newcastle-underLyme... Read more

   The idea is eventually to host a competition day and invite other local schools to come and join in with a multi-skills, multi-sport event." For the moment, the Young Leaders at Newcastle-underLyme Junior School help out with school events throughout the year, but particularly Sports Day. Read less

   Magazine Article  |  Full Text Online

3. A job that no one really notices 2014

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB5se_FUX-CzRPAauq8km5NUsSj0INSDt5LNA5HarbY99N87s92l9SAIXhYWQphhwsxk5ss3ADe6IIpNJ3ikleGZNDHXxiVcOhMwOnthq9EJO8WcDZqQ3sLU9m3cYuWrXWmpTN7HZF7n9HIyup1_chocRQ3WeopGCzoxkbsRei963pZZ6EhXD-LwsiF4lon8p9dN61Ay7MJHI0SFIKG5BbtQ-n5FX1hxVjRUjf8S-AC6DYc0G2xOySHs-dkRzWuusR3HwAbsvSzY8s0s2axkJS7GZHI6XeMfoeMWJzAePrzcP_J6dgKfS9TTyEhh-Atx4mVutQhBuVQ5idJoG1RaJPiVEtOLIvEudzGRdHsbck2NMpeeAkudjtH3iczhpaWwqbG5C1IlLsEUKwv5GVw3Sk_wSFKfwcx8uVpMtmr_viZJVaSJBFGc_2GfC9jHRKVGzFxCe_m18lfQJtP0oKVe73rQGYzGo6deZf1v3aG8Zw

   Green, Jane Bewick

   Conference & Common Room, Vol. 51, Issue 1, p. 21.

   "The biggest issue we have here is the single pipe heating system that has been in place for decades. Because of the size of the school, it's not something we can easily replace, so we spend a lot ... Read more

   "The biggest issue we have here is the single pipe heating system that has been in place for decades. Because of the size of the school, it's not something we can easily replace, so we spend a lot of time making sure it's as efficient as possible. The school has an excellent sporting record and its facilities include cricket, rugby, netball and football pitches, tennis courts, a super new Sport England badminton facility, and a swimming pool. Read less

   Magazine Article  |  Full Text Online

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