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1. A New Recalibrated Four-Category Child–Pugh Score Performs Better than the Original Child–Pugh... 2020

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwEDdsSIgXvjUyxnQg3sBaGieNh6ZJbbcKJioqjQFvlpPatGJKp7R94I3_gf-Qv4S7ywed-BB7aNQ4ztWu7fOd7-53QjyPcdNMnQql17orybInMxeGMvf5xIaJ9Z69LdYOc9o4bnZ2byySzKjbWDfSFsjval9SvGlH6g1xI-mgFk7h4Wcnrekg7Ya1gTKWKLyoOlLmzzQu70a_iZhr5tEWSvSyFMvb0PCOME0wD3ufUM6DdTf8PYY-ZLyLNZjHq3T2rrhdS6jQq6bUPXHdFffFzVFtg39w7VkPkDMCypuWdW0UWWGIL8kBgU7My69wMD1kxOSDvenhj2_f8Xa8-jyFU0LMpDIYV9EKC-hzMBHQ8T1eHLyr03T9hQS_bIsJjI7fHlEdJrng4lkB45IaSX7c8KaQTUYUGLGGgdoG1Tly5ESPuju3u1clCJ7lMJiV5XSOXYZxhTS7ADqihl6-Wjr4YAl7CWn1z6vd_hVY_AfsuWRnJBgglXIJDcLLQ3E2PH4_eC3rTBMyj1Hfkt39OMy8i5XrdrSOvVZZZCe4yGwSdV2k0lB7TXmesogMwT5DwcpNYm9VZvPYTtQjAVluU5_FHR8ioRy_6sjGuQ6x3KO2bwPxoplq5qJCEjEtZjSPt8HxNjzeRgdip5mNpuYqCxMRPBoxzTQQT9vHyA_IyGMLN19xHdSRE5T7ArFVzeL251Qn0QqfBeJlM-1-Ef9XW6Jq6reECJOcNnhTl3-Z0ccsHGqSlB8gVCoQipfJf_TVfDw57Q85Xez21Vr2WNyK6PyDj8R2xOayXLknYpOW3a7YSD-lfO3vMof4Ca4AYDY

   Krige, Jake; Spence, Richard T.; Jonas, Eduard; Hoogerboord, Marius...

   World Journal Of Surgery, Vol. 44, Issue 1, pp. 241 - 246.

   Background There currently is no consensus on how to accurately predict early rebleeding and death after a major variceal bleed. This study investigated the relative predictive performances of the ... Read more

   Background There currently is no consensus on how to accurately predict early rebleeding and death after a major variceal bleed. This study investigated the relative predictive performances of the original Child–Pugh (CP), model for end-stage liver disease (MELD) and a four-category recalibrated Child–Pugh (rCP). Methods This prospective study included all adult patients admitted to Groote Schuur Hospital with acute esophageal variceal bleeding secondary to alcoholic cirrhosis, between January 2000 and December 2017. CP and rCP grades and MELD score were calculated on admission, and the predictive ability in discriminating in-hospital rebleeding and death was compared by area under receiver-operating characteristic (AUROC) curves. Results During the study period, 403 consecutive adult patients were treated for bleeding esophageal varices of whom 225 were secondary to alcoholic cirrhosis. Twenty-four (10.6%) patients were CP grade A, 88 (39.1%) grade B and 113 (50.2%) grade C on hospital admission. MELD scores ranged from 6 to 40. Thirty-one (13.8%) patients rebleed, and 41 (18.2%) patients died. There was no difference in the discriminatory capacity of the CP (AUROC 0.59, 95% CI 0.50–0.670) and MELD (AUROC 0.62, 95% CI 0.51–0.73) to predict rebleeding ( p  = 0.72), or between the Child–Pugh (AUROC 0.75, 95% CI 0.71–0.81) and MELD (AUROC 0.71, 95% CI 0.62–0.80) to predict death ( p  = 0.35). The rCP classification (A–D) had a significantly improved discriminatory capacity (AUROC 0.83 95% CI 0.77–0.89) compared to the CP score (A–C) and MELD to predict death ( p  = 0.004). Conclusion A recalibrated Child–Pugh score outperforms the original Child–Pugh grade and MELD score in predicting in-hospital death in patients with bleeding esophageal varices secondary to alcoholic cirrhosis. Read less

   Journal Article  |  Full Text Online

2. Response to: Letter to the Editor “ Child‐Turcotte‐Pugh score as a model for organ allocation in... 2023

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtNAEF5BKiEuCFokCgUNCHEJbh3bcWxUVYpKGiql5Ucp4mZtnF1iKdiWnRy45RF4ADjzXrnzDszsrh0XoaqIS7TZdTaJ5_PM7Oy3M4w999Bo9oRrWzIIfIt29qyJsG0rlvGU210upWJbNIM5v6qzMH9lsR_8t2ixD4VLR2X_Qbz1pNiBbRQyvqKY8fVagv6gWa5UAoOW9_p8TuVSDqb4xBbtitJwrDIZ1wSH8bKg1Ayi7nhHJXtKymxJ9We4rpOjmIiq-lObdul1jI_iJHPidFCRibTM51yfYVJKLBfFjOdlO5tPqWA6apH5vP0523zz66ZPPFLTJM3QZE0T0sWy3y-TIkmzDXkojVX_KS7Lk9quDBHpRNpRQx_R8BVJ_ZEzyjWpg7fDZFmKPBfNeIezYc5dV6s2tLlH3A9HH2jeF80-Y3qMCdCZoiqo202F7prwq6jeulcYHrzv-51uT5_5vpzc-_xtdHIxGkXjwafxTbbl9MLQabGt_uB0eF5ve4Whqhda_26TCouoZ_XUlx2ohv_gGKdofJfdMasZ6GtU3mM3RLrNdvooxuzLV3gBil-sNm622a0zQ-PYYT8rzMIiewUasdgERCxoxMJ69f1wdqTgengwO1qvvlVgxSaOEFJBIZWGgZfAQaEVEK2g0AobtEKSgkIr_IHWl2CwCohOSEpQWAXC6nr14z67OBmMj99YpmKIFaMrv7BkKEM_tqkmqu_xSWcSo01Crz6wOfq9wnGFL3DJ4fpSSrzMiREIsiuk7UwlroyE-4DBJOY9OfE60pbCi7EZONyLAxv7Zddx-S57Vt3_KNcZYaJqJY3_JFJC2mV7lWQioyvKiA6B91A3Bt4ue1oPozqnPTqeimyprkEPO_SD7sOrp3jEbm-ejj3WWhRL8Zi1SGU-MbD6DdaExKo

   Lai, Quirino; Lenci, Ilaria; Giannelli, Valerio; Marrone, Giuseppe

   Liver International, Vol. 43, Issue 10, pp. 2332 - 2333.

   Journal Article  |  Full Text Online

3. Alteration of prognostic efficacy of albumin‐bilirubin grade and Child‐Pugh score according to... 2022

   https://ncsu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Pi9QwFA_unryIomh1XSJ6EjrNNGnTwrIwu7jqQVlQ0Vt5TZPpwEy7TGeQvfkR_ICe_CS-l2nLDv45eCltGpo0eY_3J7_8wtgLhUZTWylCl2VpSCt7YWmFCI0zFYgEnPNoixvJHJYMe2E8aN-Ui0mzXE2aRe2xlVcrEw04sejy3XmmszTNZXTADrRUN0J0n1hBhydO5EhFGkcw7-SEDlmmw_kkCiH63HLPDnm6_j_5mL9DJUcXVvY26OIuu9M7j3y26-Q9dss299mP2dIzI-MA89ZxAlw1LbEvc0v0EGCuqdjDkBfNz2_fCQ273mJAzOdrqCyHpuIn9annOD6J6lOsgo-X23nNO-K4pDIOhqJUNHN80_IlYTm4w0C77RYdxy_VaNQ2LS0CEKqVGzqgqGlXwHva1o5TvvcvzfgGZtyhRLZfqQn_NVpNWF0_YJ8uXn08fxP2ZzaEJqFEnbToIGbGOVHqaWXySmkFYMDlEqZ55kRijFFlnEocUi3LXJRoH4VUoPM4ASkfMV4a0K5UUyecVQZvsxiUyQSWO4ybIWDPh6krrnacHMWOfTkuaK4LP9cBO6NZHWsQj7YvaNfzopemolKpKKWzBj1RBTmG67EVADpWmQSZlQE7GmSi6JW7K-IUfSpNjnTAno2vUS1pmKGx7dbXwdCT3KeAPdyJ0NiTQQQDpveEa6-r-29QEzz1dy_5AXvpxfAfv1_MXn-Q_u7xfzfzhN2OabeHzzgdscPNemufskPaXHKMqvdF--vZsVdAvH5--_4X9lQ8qA

   Miyata, Tatsunori; Yamashita, Yo‐ichi; Arima, Kota; Higashi, Takaaki...

   Annals Of Gastroenterological Surgery, Vol. 6, Issue 1, pp. 127 - 134.

   Background The albumin‐bilirubin (ALBI) grade was developed to predict the prognosis of patients with hepatocellular carcinoma (HCC), which can stratify the prognosis even in HCC patients with Chil... Read more

   Background The albumin‐bilirubin (ALBI) grade was developed to predict the prognosis of patients with hepatocellular carcinoma (HCC), which can stratify the prognosis even in HCC patients with Child‐Pugh A. We evaluated the prognostic efficacy of the ALBI grade and Child‐Pugh classification in HCC patients with Child‐Pugh A stratified by the presence or absence of advanced fibrosis or a preoperative biomarker for advanced fibrosis. Methods We retrospectively analyzed 490 consecutive HCC patients with Child‐Pugh A who underwent initial hepatectomies. The accuracy of prognostic prediction using both models was compared by the presence or absence of advanced fibrosis (F3‐4) and its predictor, the preoperative platelet count (PLT). Results The prognostic accuracy of the ALBI grade was better in patients without advanced fibrosis (F3‐4; likelihood ratio: 4.39, corrected Akaike information criterion [AICc]: 453.0, P = .074), but Child‐Pugh score was better in the advanced fibrosis group (likelihood ratio: 10.67, AICc: 915.2, P = .0014). In the high PLT group (≥140 × 103/μL), the prognostic accuracy using the ALBI grade was better in overall survival (OS) and relapse‐free survival (RFS), but in the low PLT group, the Child‐Pugh score was the more accurate model in OS and RFS. Conclusions Depending on the degree of fibrosis or preoperative PLT, the ALBI grade and Child‐Pugh score may provide more accurate prognoses after initial hepatectomy in HCC patients with Child‐Pugh A. Depending on the degree of fibrosis and preoperative platelet count (PLT), the albumin‐bilirubin (ALBI) grade or Child‐Pugh score may provide more accurate prognoses after initial hepatectomy in HCC patients with Child‐Pugh A. Read less

   Journal Article  |  Full Text Online

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