Articles

    1. TRANSMISSION RATIO DISTORTION IN MICE 2003

      Lyon, Mary F

      Annual Review Of Genetics, Vol. 37, Issue 1, pp. 393 - 408.

      The most studied example of transmission ratio distortion (TRD) in mice is that of the t -complex. This is a variant region of Chromosome 17 which exists as a polymorphism in wild mice. Males heter... Read more

      The most studied example of transmission ratio distortion (TRD) in mice is that of the t -complex. This is a variant region of Chromosome 17 which exists as a polymorphism in wild mice. Males heterozygous for a t -haplotype and a normal Chr 17 transmit the t -haplotype to >50% of their young, up to 99%. Homozygous males are sterile. The TRD produced by the t -complex is due to the action of three or more distorter genes ( Tcd ) on a responder gene ( Tcr ). t-Haplotypes are maintained intact by crossover suppression induced by four neighboring inversions, the Tcd and Tcr loci lying in different inversions. Sperm formation is normal in t/t males, but sperm function is impaired through gross defects in sperm motility. The responder gene has been identified as a fusion gene formed from a sperm motility kinase and a ribosomal S6 kinase. Three candidate distorter genes have also been identified as genes coding for dynein chains, and thus possibly involved in sperm flagellar function. Read less

      Journal Article  |  Full Text Online

    2. The Lyon and the LINE hypothesis 2003

      Lyon, Mary F

      Seminars In Cell & Developmental Biology, Vol. 14, Issue 6, pp. 313 - 318.

      X-chromosome inactivation (XCI) was first suggested as an explanation for the variegated phenotypes in mice heterozygous for X-linked colour genes or for X-autosome translocations involving autosom... Read more

      X-chromosome inactivation (XCI) was first suggested as an explanation for the variegated phenotypes in mice heterozygous for X-linked colour genes or for X-autosome translocations involving autosomal coat colour genes. The effects seen in X-autosome translocations led to the suggestion of an X-inactivation centre (Xic) from which the inactivation was initiated, and this suggestion has led to major advances in understanding. Another feature of X-autosome translocations is incomplete inactivation of the attached autosomal segment, implying that the X-chromosome is enriched in features favouring inactivation. Interspersed repeat elements, and in particular long interspersed elements (LINEs), have been suggested as the relevant enriching features. Recent evidence concerning this hypothesis is discussed. Read less

      Journal Article  |  Full Text Online

    3. Mary F. Lyon (1925-2014) 2015

      Rastan, Sohaila

      Nature (London), Vol. 518, Issue 7537, p. 36.

      Journal Article  |  Full Text Online

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    1. Not a station but a place : drawings/collages of and related to the Gare de Lyon, Paris

      by Judith S. Clancy ; introduced by M.F.K. Fisher.

      Hill NC139 .C567 A4 1979 | Book

    2. Flexible query answering systems : 6th international conference, FQAS 2004, Lyon, France, June...

      Henning Christiansen ... [and others] (eds.).

      Hunt QA76.9 .Q4 F653 2004 | Book

    3. New advances in modal synthesis of large structures : non-linear damped and non-deterministic...

      edited by Louis Jezequel.

      Hunt TA645 .I57 1997 | Book

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    1. Introduction to F#

      Learn the fundamentals of the F# language through a hands-on console application.

      Learn the fundamentals of the F# language through a hands-on console application. Read less

    2. Functional Programming with F# and C# by Microsoft Press

      Enhance your skills as a developer by programming in the functional style, without mathematical formulas or advanced concepts.

      Enhance your skills as a developer by programming in the functional style, without mathematical formulas or advanced concepts. Read less

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    1. FocusVol.30no.4.sm__1.pdf

      Starlings Lyon, and John Claude Bemis were on hand to read and sign books, and Festival favorite R.L. Stine had fans driving from hours away just to see their favorite childhood

      Starlings Lyon, and John Claude Bemis were on hand to read and sign books, and Festival favorite R.L. Stine had fans driving from hours away just to see their favorite childhood Read less

    2. Untitled-2

      ...e Hunt Library is unlike any most people have ever entered. What do you do /f_irst when you walk into a library and aren’t surrounded by rows of shelving—a library where robots deliver the books... Read more

      ...e Hunt Library is unlike any most people have ever entered. What do you do /f_irst when you walk into a library and aren’t surrounded by rows of shelving—a library where robots deliver the books? Or where ADVENTUR OUS COLLABORATI ON HONORED WITH 2012 FACULTY AW ARDnew, advanced, and sometimes unfamiliar technology is around every corner? In the 2012 spring semester, Professors Buie and Y oung combined their advanced design and computer engineering capstone courses to present their best and brightest with the real-world challenge of shaping how the library would be experienced once it opened. One group of students concentrated on working with a digital palette the size of which they could only have dreamed about in the past. Using a prototype of the 21-foot-wide video wall that is the centerpiece of the Game Lab, they developed a video game built for a screen so large and infused with color that it is at the frontier of today’s digital displays.Other groups from the collaborative class—the “experience designers”— developed detailed plans for how to arrange the technology, the signage, and the furniture to turn some of the library’s most unique areas into intuitively usable spaces. /T_he Hunt Library was conceived to encourage students to dream big. A full year before the new library opened, the 2012 Faculty Award winners gave their students access to experiences they wouldn’t have had on any other campus on the globe. And the students noticed: one ended the course saying the cross-disciplinary opportunity was “the greatest experience that I’ve had so far in college. ” /T_hat’s the promise of the Hunt Library. Professor Tim Buie and Dr. Michael YoungI. T. Littleton and Steven J. BellSusan K. Nutter and Dr. Mike Eisenberg 4|FOCUS - NCSU LibrariesLIBRARIE S NEW S ADVENTUR OUS COLLABORATI ON HONORED WITH 2012 FACULTY LTY LAWARDAWARDAWFACULTY AW ARD HONORROLL /T_he NCSU Libraries is proud to recognize the distinguished recent winners of our Annual Faculty Award. DOUGLAS S. REEVES, 2011 Professor of Computer Science and Electrical and Computer Engineering When the Hunt Library opened, much of the praise it received centered on how well it met the actual needs of twenty-/f_irst century students and researchers. /T_his success was in no small part due to the advice and support that Professor Douglas Reeves gave when the Libraries needed community input. A long-time member of the University Library Committee (ULC)—and its chair for three years during Hunt Library planning—his “leadership style, ” as one observer wrote, “insured that all members, in particular, the student representatives, felt free to contribute to the discussions. ” /T_his wise inclusivity paid off in other key ways. It was Reeves’ idea to add a Centennial Campus representative to the ULC, engaging that important community early; and he leveraged a mutual love of books and libraries to bring in a Cisco executive to head the Hunt Library Technology Advisory Board. Most of all, Professor Reeves consistently provided a strong faculty voice for what a great library could be in the Internet age, a strength captured in a letter of nomination from another faculty member: “Doug understands the changing nature of libraries in the digital environment and the challenges they face in order to be vital drivers of research, learning, and collaboration . . . . He has lent his ideas and support to everything from digital technologies to increase use and discovery of library content, to enhancing spaces provided to students, to aggressively expanding online-only journal content. ” DAVID ZONDERMAN, 2010 Professor of History /T_he Libraries’ Special Collections Research Center is documenting the birth of the North Carolina Research Center in Kannapolis, where the UNC system and patron David Murdock from Dole Foods are collaborating to build a thriving bio- technical center in a small town blighted by the loss of textile manufacturing. /T_he Libraries and the Center organized a series of public lectures, some in Raleigh, some in Kannapolis, to build excitement around the project. As an expert on labor and its history and one who takes seriously the land-grant promise that universities should change the world, Professor David Zonderman anchored several of these programs. /T_hat passion to engage real-world problems has also marked the considerable work Professor Zonderman has done in the past with the Libraries. He has served on the University Library Committee for a dozen years and on the committee that set the direction for the Learning Commons in the D. H. Hill Library. When we set out in the 1990s to become one of the /f_irst academic libraries in the nation to tackle the o/f_ten-vexing changes in scholarly communications, Professor Zonderman chaired the committee to establish our Scholarly Communication Center and hire our /f_irst Scholarly Communication librarian, becoming, as one of his recommenders put it, “a pioneer in the access to new electronic resources for the humanities disciplines” at NC State. JAMES WILSON, 2009 Professor of Industrial and Systems Engineering If a library database goes down or an online journal temporarily blinks out during a network outage, the chances are that the /f_irst person to report it is going to be Professor Jim Wilson. /T_hat’s because he’s a world-class library user, someone the Libraries always listens to because he is deeply involved in using our services and evangelizing them to his students and peers. Several times when staff has reached dead ends over issues with one of our vendors, Professor Wilson has, for instance, just picked up the phone, called an editor or publisher, and the problem has gone away. He is, as one nominator put it, “the kind of active library user that helps keep a modern digital collection responsive to its community. ” When the history of technology in the past several decades is told, the cra/f_t of computer simulation will dominate it. Simulation technologies have transformed everything from computer engineering to biotechnology, transportation, and the role-playing and video game industry. /T_he scholars who tell that story will stop /f_irst at the NCSU Libraries Special Collections Research Center, where they will /f_ind— thanks largely to Professor Wilson’s vision and hard work—the /f_inest simulation collection in the world. 5 NCSU Libraries - FOCUS |LIBRARIE S NEW S Susan K. Nutter and Professor Doug Reeves Professor David ZondermanProfessor James WilsonFRIENDS OF THELIBRARY FALL LUNCHEON During the 2012 Friends of the Library Fall Luncheon, Friends President Hope Tate welcomed guests and thanked the Friends for their stalwart support of the NCSU Libraries. Meg Lowman, Research Professor, College of Sciences, NC State and Senior Scientist and Director of Academic Partner - ships & Global Initiatives at the North Carolina Museum of Natural Sciences, delighted and inspired guests with stories about her research in the canopies of the rain forest and her work with young people, especially girls, around the world. Closing the luncheon, Vice Provost and Director of Libraries Susan K. Nutter presented the 24th annual NCSU Libraries Faculty Award to Professor Timothy Buie from the Industrial Design program in the College of Design and Dr. Michael Y oung from the Department of Computer Science for their pioneering work in leading a collaborative course that explored the technologies and spaces in the new James B. Hunt Jr. Library. Provost Warwick Arden and Meg Lowman chat during the Fall Luncheon. Pho - tograph by Marc Hall, University Communications. Saul Flores | Photographs The Walk of the Immigrants January 2012–August 2012 Last winter, the D. H. Hill Library Exhibit Gallery came to life with vibrant color and compelling stories told through the portraits, landscapes, and cityscapes photographed by Saul Flores, ’12, during an epic 5,000-mile journey, mostly by foot, through Central and South America in 2010. On this journey—inspired by an earlier service trip with the Caldwell Fellows leadership development program—Flores took over 20,000 photos to “raise awareness of the beauty of these Latin American countries as well as the struggles that their people face.” Proceeds from the sale of his photographs and sponsorships of his journey are aiding an elementary school in his mother’s hometown, the small rural community of Atencingo, Mexico. A virtual version of the exhibit is now playing in the iPearl Immersion Theater, where its striking colors capitalize on the ability of the Hunt Library’s display walls to showcase exemplary student work in a large, radiant format. NC State University, 125 Years of Shaping the Future September 2012–August 2013 Celebrating the university’s one hundred twenty- fifth anniversary, 125 Years of Shaping the Future explores our history from the tenacity of the Watauga Club members who fought for the establishment of the North Carolina College of Agriculture and Mechanic Arts in 1887 to current research and creative thinking in fields as diverse as Universal Design and Molecular Paleontology. Through August 2013, visitors can see the artifacts, papers, photographs, and ephemera that are usually stored safely away from light in our vaults and reflect on a legacy of improving our citizens’ lives with a reach that has grown from spanning the one hundred counties of North Carolina to engaging the world. A digital version of the exhibit is available in the Hunt Library’s iPearl Immersion Theater. For more information about this exhibit and others, please contact Molly Renda at molly_renda@ncsu.edu. 6|FOCUS - NCSU LibrariesFRIENDS OFTHE LIBRARY NEWS EXHIBITS N EWS Arts in 1887 as Universal Paleontology. Through August 2013, visitors can see the artifacts, papers, photographs, and ephemera that are usually stored safely away from light in our vaults and reflect lives with a reach that has grown from North Carolina to engaging the world. For more information about this exhibit It started with a medieval manuscript in a shoebox and ended with an endowment that will support some of the latest in modern library technologies. From an early book to the bookBot—that is the arc of the story of the Hunt Library’s new “Turlibot.” Linda Turlington’s family had long treasured a fifteenth- century book of meditations that has been passed down from generation to generation. And that family is, as Turling- ton explains, “completely red and white.” Her husband of almost 40 years, Jimmy, is a 1968 NC State graduate in civil engineering. Her son Ryan obtained his B.S. from the College of Textiles in 2001. Daughter Courtney earned her B.A. from the College of Humanities and Social Sciences in 2007. So when the family decided that the Latin manuscript—once laboriously copied out by Carthusian monks—needed a safer long-term home where its treasures could be available to scholars throughout the w... Read less

    3. Untitled-1

      ... in New York, the zone was dubbed the “Apple Store” during the planning phase for the Hunt Library. Now, in a great bit of serendipity, the signature space will forever be called the Lawrence an... Read more

      ... in New York, the zone was dubbed the “Apple Store” during the planning phase for the Hunt Library. Now, in a great bit of serendipity, the signature space will forever be called the Lawrence and Ella Apple Technology Showcase. The NCSU Libraries has earned an international reputation for being a technology incubator, both at the university and for academic libraries in general. Last year, for instance, the Libraries loaned out almost 100,000 iPads, DSLR cameras, camcorders, laptops, graphics tablets, e-readers, and other technology. As former Senior Class President Jay Dawkins recently put it, “in the ‘real world’ these devices are often reserved for professionals making a lot of money—there are a lot of barriers to these technologies. The Libraries puts them into the hands of students who are being creative with them, who can take the technology and put their ideas into action.” The Tech Showcase will visually invite users to explore the technology that is there for the asking. Students Lawrence and Ella Apple Name Key Technology Space in New Hunt Library entering the building will immediately be able to see what is available to help them boost creativity, excel in their work, and gain technology skills that are invaluable in landing that all-important first job. The Apples, now living in Burlington, North Carolina, have in the past endowed other programs in the Libraries, support- ed graduate fellowships in the Plant Pathology Department, and lived abroad to gear up international programs at NC State, which Lawrence Apple ran during part of his tenure at the university. Lawrence Apple holds three degrees from NC State and was on the faculty from 1955-1991. In 2009, the university awarded him a Watauga Medal—NC State’s highest award for those who have rendered significant and distinguished service to the university. The Hunt Library, now nearing completion on NC State’s Centennial Campus, has been generously funded by the General Assembly and the people of North Carolina. How- ever, naming and other giving opportunities will help ensure that the vision of the Hunt Library as a major competitive advantage for NC State students and faculty, as well as for the economy of North Carolina, can be realized.Donor Spotlight: Lawrence and Ella Apple Apple Technology Showcase 5 NCSU Libraries - FOCUS |But you wouldn’t know this standing outside the D. H. Hill Library at 8:55 a.m. on the /f_irst Saturday of last fall semester. On this beautiful, sunny day in late August, the weather is perfect for driving to the beach to savor the waning moments of summer. Nonetheless, a small crowd has assembled outside the library, waiting for its doors to open at 9 o’ clock. /T_here’s no special promotion, no imminent exam or assignment due; these students just want in. /T_he doors open with an audible click and the stu- dents /f_ile in briskly, heading purposefully toward their spots in the Learning Commons, the stacks, and the Special Collections Reading Room. It’s the beginning of another typical day at the NCSU Libraries. STUDENT SPACES During the busiest periods of the semester, the NCSU Librar - ies receives more than 10,000 in-person visits per day – that’s almost one-third the total enrollment at NC State walking in the door. And these aren’t simply drop-in visits to quickly check email or pick up a book. As students will tell you, they live in the Libraries. At exam time, “you might as well forward [my] mail to the library, ” notes Priyaaka Varatan, a Biomedical Engineering student who is hunkered down with two classmates in a very popular group study room just off the Learning Commons at the D. H. Hill Library. But, it’s important to realize that student time in the Libraries isn’t just about studying. Kelli Rogers, political science gradu- ate and former president of the Student Senate, explained, “It’s so much more than an opportunity to come and to learn . . . it’s really an opportunity, at the Libraries, to come and to experience NC State with your friends. ” /T_his view of the library as a place for more than just schoolwork is central to the NCSU Libraries’ vision for its physical spaces. In today’s environment, access to spaces for convening, collaborating, relaxing, creating, and experimenting (to name a few) can be critical to student success and well-being. Of additional importance is the role that library spaces play in fostering a sense of belonging at NC State. Ellen /T_homas, a graduate student in food science, likes to sit in the serpentine booths on the main /f_loor of D. H. Hill “because you still feel like you’re near people but you feel like you have your own space. ” A sense of ownership and the feeling of being with a shared community are two major reasons that students choose to spend so much of their time in the Libraries. /T_he NCSU Libraries has been dedicated to perfecting the equation for designing spaces that best meet our students’ work and life needs. /T_his endeavor has included surveys and focus groups, student and faculty advisory groups, gathering student input in design workshops and furniture testing, and even ethnographic techniques like participant observation and asking students to document their daily lives through photographs. THE HUNT LIBRARY — SPACES FOR WORKING In the great NC State tradition of putting research into prac- tice, the new James B. Hunt Jr. Library builds on everything we’ve learned about university life and the needs of our users. Although a lot of activity occurs on Centennial Campus, the majority of it takes place behind closed doors, inside offices and research labs, with few suitable spaces for students and researchers to gather. /T_he Hunt Library will not only become this central gathering space, it will also be a unique and The library was once the unquestioned heart of the university campus simply because it held all of the books, journals, and other materials instrumental to teaching and learning. With the rise of digital technologies, students and faculty can now access a large amount of the information they need remotely, through online journals and databases, e-books, and the Internet. Because the library makes all of these resources available from home at the click of a mouse, it might seem like there’s little need to go into the physical library building any more. 6| FOCUS - NCSU Libraries DISTINCTIVE LEARNING SPACES Students flock to the Libraries.much-needed learning space on Centennial Campus. One of the aims of the Hunt Library is to address the serious lack of study seating at NC State University. /T_he UNC system stan- dard recommends library seating for 20% of the student population; NC State has space for less than 5%. /T_he addition of the Hunt Library will double this number, providing plenty of spaces for students to concen- trate and get serious, while the installation of the bookBot automated book delivery system will free up even more precious square footage that would normally be occupied by book stacks, allowing for more learning spaces. Numerous reading areas, each with its own distinct style and character, will be available throughout the building. /T_he Main Read- ing Room will be an elegant, bright, and airy take on the traditional scholarly reading room, while the Rain Garden Reading Lounge will offer comfortable lounge seating and a contemplative view of the garden’s greenery. For those who prefer a higher vantage point, the Skyline Reading Room will provide breathtaking views of Lake Raleigh and the downtown skyline, and the adjacent Skyline Terrace will give students the ability to work while taking advantage of the Carolina sunshine. /T_he Hunt Library will be a place where students and faculty can work, play, eat, relax, get help, try out new technologies, encounter people working in other disciplines, and share ideas and information. Most impor - tantly, it will be a place they’ll want to visit every day. SPACES TO C OLL ABORATE Supporting the kind of learning that takes place on today’s university campus requires more than a sturdy table and a comfy chair. Coursework and research at NC State aren’t just by-the-book: they are frequently active, applied, and collaborative. “Instructors are assigning more team projects and encouraging group study to help students engage more deeply with the course content through collaboration, as well as to enhance their communication and teamwork skills, ” observes Kim Duckett, Principal Librarian for Digital Technologies and Learning. /T_his tendency to work together extends beyond class assignments; for many of today’s stu-dents, it’s a way of life. As Duckett explains, “ ‘Net gen’ students are characteristically highly social and collaborative. Many students like working together, even if they’re not always working on the same project. ” /T_he incredible success of the Learning Commons at the D. H. Hill Library demonstrates that students crave adaptable, varied spaces that can accommodate different activities, from individual study to group problem solving around a whiteboard to watching Y ouTube videos with a friend. /T_he James B. Hunt Jr. Library will feature two separate Learning Commons spaces and almost 100 reservable, collaborative group study rooms. In addition, the Hunt Library will also provide dedicated Commons spaces for faculty members and graduate students, two user groups who do not currently have their own library spaces for working, meeting up, and interacting across colleges and disciplines. YOUR SPACE /T_he new spaces under construction for the Hunt Library have received overwhelmingly positive reviews from the students who have seen them. /T_here’s a buzz around the project that only comes ... Read less

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