Articles

    1. ‘PALEOVAN’, International Continental Scientific Drilling Program (ICDP): site survey results and... 2009

      Litt, Thomas; Krastel, Sebastian; Sturm, Michael; Kipfer, Rolf; Örcen, Sefer...

      Quaternary Science Reviews, Vol. 28, Issue 15, pp. 1555 - 1567.

      Lake Van is the fourth largest terminal lake in the world (volume 607 km 3, area 3570 km 2, maximum depth 460 m), extending for 130 km WSW–ENE on the Eastern Anatolian High Plateau, Turkey. The sed... Read more

      Lake Van is the fourth largest terminal lake in the world (volume 607 km 3, area 3570 km 2, maximum depth 460 m), extending for 130 km WSW–ENE on the Eastern Anatolian High Plateau, Turkey. The sedimentary record of Lake Van, partly laminated, has the potential to obtain a long and continuous continental sequence that covers several glacial–interglacial cycles (ca 500 kyr). Therefore, Lake Van is a key site within the International Continental Scientific Drilling Program (ICDP) for the investigation of the Quaternary climate evolution in the Near East (‘PALEOVAN’). As preparation for an ICDP drilling campaign, a site survey was carried out during the past years. We collected 50 seismic profiles with a total length of ∼850 km to identify continuous undisturbed sedimentary sequences for potential ICDP locations. Based on the seismic results, we cored 10 different locations to water depths of up to 420 m. Multidisciplinary scientific work at positions of a proposed ICDP drill site included measurements of magnetic susceptibility, physical properties, stable isotopes, XRF scans, and pollen and spores. This core extends back to the Last Glacial Maximum (LGM), a more extended record than all the other Lake Van cores obtained to date. Both coring and seismic data do not show any indication that the deepest part of the lake (Tatvan Basin, Ahlat Ridge) was dry or almost dry during past times. These results show potential for obtaining a continuous undisturbed, long continental palaeoclimate record. In addition, this paper discusses the potential of ‘PALEOVAN’ to establish new results on the dynamics of lake level fluctuations, noble gas concentration in pore water of the lake sediment, history of volcanism and volcanic activities based on tephrostratigraphy, and paleoseismic and earthquake activities. Read less

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    2. Patients’ Attitudes and Perceptions Regarding Social Needs Screening and Navigation: Multi-site... 2020

      Rogers, Artair J.; Hamity, Courtnee; Sharp, Adam L.; Jackson, Ana H....

      Journal Of General Internal Medicine : Jgim, Vol. 35, Issue 5, pp. 1389 - 1395.

      Background As more health care organizations integrate social needs screening and navigation programs into clinical care delivery, the patient perspective is necessary to guide implementation and a... Read more

      Background As more health care organizations integrate social needs screening and navigation programs into clinical care delivery, the patient perspective is necessary to guide implementation and achieve patient-centered care. Objectives To examine patients’ perceptions of whether social needs affect health and attitudes toward healthcare system efforts to screen for and address social needs. Research Design Multi-site, self-administered survey to assess (1) patient perceptions of the health impact of commonly identified social needs; (2) experience of social needs; (3) degree of support for a health system addressing social needs, including which social needs should be screened for and intervened upon; and (4) attitudes toward a health system utilizing resources to address social needs. Analyses were conducted using multivariable logistic regression models with clinic site cluster adjustment. Subjects Adult patients at seven primary care clinics within a large, integrated health system in Southern California. Main Measures Survey measures of experience with, acceptability of, and attitudes toward clinical social determinants of health screening and navigation. Key Results A total of 1161 patients participated, representing a 79% response rate. Most respondents (69%) agreed that social needs impact health and agreed their health system should ask about social needs (85%) and help address social needs (88%). Patients with social needs in the last year were more likely to (1) agree social needs impact health (OR 10.2, p  < 0.001), (2) support their health system asking patients about social needs (OR 3.7, p  < 0.001), and (3) support addressing patient social needs (OR 3.5, p  < 0.001). Differences by social need history, gender, age, race, ethnicity, and education were found. Conclusions Most patients at a large integrated health system supported clinical social needs screening and intervention. Differences in attitudes by social need history, gender, age, race, ethnicity, and education may indicate opportunities to develop more equitable, patient-centered approaches to addressing social needs. Read less

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    3. Factors influencing parents' choice of palliative treatment goals for children with relapsed or... 2024

      Kaye, Erica C; Smith, Jesse; Zhou, Yiwang; Bagatell, Rochelle...

      Cancer, Vol. 130, Issue 7, pp. 1101 - 1111.

      Many parents of children with advanced cancer report curative goals and continue intensive therapies that can compound symptoms and suffering. Factors that influence parents to choose palliation as... Read more

      Many parents of children with advanced cancer report curative goals and continue intensive therapies that can compound symptoms and suffering. Factors that influence parents to choose palliation as the primary treatment goal are not well understood. The objective of this study was to examine experiences impacting parents' report of palliative goals adjusted for time. The authors hypothesized that awareness of poor prognosis, recall of oncologists' prognostic disclosure, intensive treatments, and burdensome symptoms and suffering would influence palliative goal-setting. The authors collected prospective, longitudinal surveys from parents of children with relapsed/refractory neuroblastoma at nine pediatric cancer centers across the United States, beginning at relapse and continuing every 3 months for 18 months or until death. Hypothesized covariates were examined for possible associations with parental report of palliative goals. Generalized linear mixed models were used to evaluate factors associated with parents' report of palliative goals at different time points. A total of 96 parents completed surveys. Parents were more likely to report a primary goal of palliation when they recalled communication about prognosis by their child's oncologist (odds ratio [OR], 52.48; p = .010). Treatment intensity and previous ineffective therapeutic regimens were not associated with parents' report of palliative goals adjusted for time. A parent who reported new suffering for their child was less likely to report palliative goals (OR, 0.13; p = .008). Parents of children with poor prognosis cancer may not report palliative goals spontaneously in the setting of treatment-related suffering. Prognostic communication, however, does influence palliative goal-setting. Evidence-based interventions are needed to encourage timely, person-centered prognostic disclosure in the setting of advanced pediatric cancer. Many parents of children with poor-prognosis cancer continue to pursue curative treatments that may worsen symptoms and suffering. Little is known about which factors influence parents to choose palliative care as their child's main treatment goal. To explore this question, we asked parents of children with advanced neuroblastoma across the United States to complete multiple surveys over time. We found that the intensity of treatment, number of treatments, and suffering from treatment did not influence parents to choose palliative goals. However, when parents remembered their child's oncologist talking about prognosis, they were more likely to choose palliative goals of care. Read less

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