Encore -- d:(Single-photon emission computed tomography)

Bone scintigraphy with SPECT/CT in paediatric patients with neck and back pain in comparison with other imaging modalities: the experience of a tertiary paediatric referral centre.

Eseonu K;Oduoza U;Robinson P;Easty M;Nadarajah R;Biassoni L

Academic Journal | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE Please log in to see more details

Objective: Retrospective review of the additional clinical value provided by single ph... more

Bone scintigraphy with SPECT/CT in paediatric patients with neck and back pain in comparison with other imaging modalities: the experience of a tertiary paediatric referral centre.

Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE

Objective: Retrospective review of the additional clinical value provided by single photon emission computed tomography-computed tomography (SPECT/CT) in children and adolescents with back pain.
Methods: A total of 207 consecutive paediatric patients (94 males, 113 females, age range 5-17 years, median age 14 years) were reviewed after referral to the spinal surgery clinic of a paediatric teaching hospital between November 2009 and February 2021. All patients had either only whole spine X-rays or whole spine x-rays and MRI, along with bone scan with planar whole-body images and SPECT/CT (with spot views of painful area).
Results: X-ray identified the pain generator in 23 of 177 (13.0%) cases. MRI identified the pain generator in 49 of 165 (29.7%) cases. SPECT/CT reported relevant positive findings which identified the pain generator in 107 of 185 (57.8%) cases. SPECT/CT changed patients' management in 72 of 185 (38.9%) cases. SPECT/CT was most effective at identifying the pain generator in cases of facet arthropathy, previous vertebral fracture and patients with previous deformity correction, where the pain generator was identified in 76.5% (13 of 17), 71.4% (5 of 7) and 63.4% (26 of 41) of cases, respectively. CT settings were adjusted to minimise the radiation burden (50 mAs/80kVp under 8 years, 24 mAs/110 kVp over 8 years).
Conclusion: The role of SPECT/CT in diagnosing back pain is justified in selected paediatric patients, particularly with diagnostic uncertainty using conventional imaging. The CT component of the SPECT/CT study produced a lower radiation dose than conventional CT imaging, whilst producing bone images of diagnostic quality.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Subject terms:

Male - Female - Humans - Child - Adolescent - Child, Preschool - Spine - Neck - Referral and Consultation - Tomography, Emission-Computed, Single-Photon methods - Single Photon Emission Computed Tomography Computed Tomography - Back Pain

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RT Journal Article A1 Eseonu K A1 Oduoza U A1 Robinson P A1 Easty M A1 Nadarajah R A1 Biassoni L T1 Bone scintigraphy with SPECT/CT in paediatric patients with neck and back pain in comparison with other imaging modalities: the experience of a tertiary paediatric referral centre. FD Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE YR 2024 VO 45 IS 4 DO 10.1097/MNM.0000000000001811 SP 278 JF Nuclear medicine communications SN 1473-5628

Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99m Tc-Sestamibi Single-photon Emission Computed Tomography/Computed...

Lughezzani G;Casale P;Evangelista L

Report | Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE Please log in to see more details

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Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99m Tc-Sestamibi Single-photon Emission Computed Tomography/Computed...

Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE

Subject terms:

Humans - Tomography, Emission-Computed, Single-Photon methods - Radiopharmaceuticals - Technetium Tc 99m Sestamibi - Single Photon Emission Computed Tomography Computed Tomography methods

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RT Journal Article A1 Lughezzani G A1 Casale P A1 Evangelista L T1 Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of <superscript>99m</superscript> Tc-Sestamibi <highlight>Single</highlight>-<highlight>photon</highlight> <highlight>Emission</highlight> <highlight>Computed</highlight> <highlight>Tomography</highlight>/<highlight>Computed</highlight> <highlight>Tomography</highlight> in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol. 2024;85:63-71. FD Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE YR 2024 VO 85 IS 3 DO 10.1016/j.eururo.2023.11.020 SP e76 JF European urology SN 1873-7560

Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99m Tc-Sestamibi Single-photon Emission Computed Tomography/Computed...

Schober JP;Wang R;Kutikov A

Report | Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE Please log in to see more details

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Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99m Tc-Sestamibi Single-photon Emission Computed Tomography/Computed...

Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE

Subject terms:

Humans - Tomography, Emission-Computed, Single-Photon methods - Radiopharmaceuticals - Technetium Tc 99m Sestamibi - Single Photon Emission Computed Tomography Computed Tomography methods

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MEDLINE

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RT Journal Article A1 Schober JP A1 Wang R A1 Kutikov A T1 Re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of <superscript>99m</superscript> Tc-Sestamibi <highlight>Single</highlight>-<highlight>photon</highlight> <highlight>Emission</highlight> <highlight>Computed</highlight> <highlight>Tomography</highlight>/<highlight>Computed</highlight> <highlight>Tomography</highlight> in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol. 2023;85:63-71. FD Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE YR 2024 VO 85 IS 2 DO 10.1016/j.eururo.2023.10.022 SP e53 JF European urology SN 1873-7560

Attacking the Achilles heel of cardiac amyloid nuclear scintigraphy: How to reduce equivocal and false positive studies.

Al Taha Z;Alibazoglu D;Sabbour H;Romany I;Alibazoglu H;Bokhari S

Academic Journal | Publisher: Elsevier Inc. on behalf of American Society of Nuclear Cardiology Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE Please log in to see more details

Background: Planar and single-photon emission computed tomography (SPECT) nuclear imag... more

Attacking the Achilles heel of cardiac amyloid nuclear scintigraphy: How to reduce equivocal and false positive studies.

Publisher: Elsevier Inc. on behalf of American Society of Nuclear Cardiology Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE

Background: Planar and single-photon emission computed tomography (SPECT) nuclear imaging techniques with bone seeking radiotracers have been increasingly adopted for diagnosis of ATTR cardiac amyloidosis. However, inherent limitations of these techniques due to lack of anatomical landmarks have been recognized, with consequent high numbers of equivocal or false positive cases. SPECT/computed tomography (CT) fusion imaging offers a significant advantage to overcome these limitations by substantially reducing inaccurate interpretations. The authors present the results of a 3-year imaging quality improvement project that focused on reducing the high number of equivocal studies that were noted in the first two years of the amyloidosis program, comparing SPECT only to SPECT/CT fusion technique.
Methods: A retrospective, systematic analysis of 176 patient records was performed to test the premise that SPECT/CT fusion imaging has the potential to reduce equivocal and false positive results.
Results: Of a total of 176 patients, 35 equivocal (19.8%), 32 (18.18%) strongly suggestive, and 109 (61.93%) not suggestive cases were identified. Recognizing that this was not consistent with the international data, the authors set out on a comprehensive quality assessment project to reduce the number of equivocal and false positive cases. In patients who initially underwent SPECT only (Group A; n = 78), the addition of SPECT/CT fusion resulted in the net reclassification of 73% of cases: 100% of equivocal cases (n = 35) were reclassified to not suggestive (n = 34) or strongly suggestive (n = 1). 73% of strongly suggestive cases (n = 30) were reclassified to not suggestive (n = 22) while 8 strongly suggestive cases were confirmed as true positives. 13 not suggestive cases remained negative after SPECT/CT fusion. In cases where SPECT/CT fusion was utilized from the beginning (Group B; n = 98), there were no reclassification of any of the cases when these cases were reprocessed as a control group.
Conclusion: Addition of SPECT/CT imaging reduces the false positive or equivocal studies and increases the diagnostic accuracy of the test. All false positive and equivocal studies were eliminated using the fusion technique. Utilizing the fusion imaging technique increases the spatial resolution, with the ability to localize myocardial uptake and accurately differentiate from blood pool, which is a major source of error.
(© 2023. The Author(s).)

Subject terms:

Humans - Retrospective Studies - Single Photon Emission Computed Tomography Computed Tomography - Tomography, Emission-Computed, Single-Photon methods - Amyloidosis

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MEDLINE

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RT Journal Article A1 Al Taha Z A1 Alibazoglu D A1 Sabbour H A1 Romany I A1 Alibazoglu H A1 Bokhari S T1 Attacking the Achilles heel of cardiac amyloid nuclear scintigraphy: How to reduce equivocal and false positive studies. FD Publisher: Elsevier Inc. on behalf of American Society of Nuclear Cardiology Country of Publication: United States NLM ID: 9423534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE YR 2023 VO 30 IS 5 DO 10.1007/s12350-023-03214-6 SP 1922 JF Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology SN 1532-6551

Patient-specific biokinetics and hybrid 2D/3D approach integration in OEDIPE software: Application to radioiodine therapy.

Bensiali M;Anizan N;Leboulleux S;Lamart S;Davesne E;Broggio D;Desbrée A;Fra...

Academic Journal | Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE Please log in to see more details

Background: The progression of targeted radionuclide therapy requires the development ... more

Patient-specific biokinetics and hybrid 2D/3D approach integration in OEDIPE software: Application to radioiodine therapy.

Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE

Background: The progression of targeted radionuclide therapy requires the development of dosimetry software accounting for patient-specific biokinetics. New functionalities were thus developed in the OEDIPE software, to deal with multiple 3D images or multiple planar images and a SPECT image.
Materiel & Method: Methods were implemented to recover patient biokinetics in volumes of interest. If several 3D SPECT images are available, they are registered to a reference CT scan. When several planar images and a single SPECT are available, the planar images are registered to the SPECT and counts of the planar images converted to activity. To validate these developments, six SPECT/CT and planar images of a Jaszczak phantom containing I-131 were acquired at different dates. Cumulated activity was estimated in each sphere using the SPECT/CT images only or the planar series associated to one SPECT/CT. Biokinetics and doses in lesions and in the lungs of a patient treated with I-131 for differentiated thyroid cancer were then estimated using four planar images and a SPECT/CT scan. Whole-body retention data were used to compare the biokinetics obtained from the planar and SPECT data.
Results: Activities and cumulated activities estimated using OEDIPE in the phantom spheres agreed well with the reference values for both approaches. Results obtained for the patient compared well with those derived from whole-body retention data.
Conclusion: The implemented features allow automatic evaluation of patient-specific biokinetics from different series of patient images, enabling patient-specific dosimetry without the need for external software to estimate the cumulated activities in different VOIs.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)

Subject terms:

Humans - Tomography, Emission-Computed, Single-Photon - Software - Iodine Radioisotopes therapeutic use - Single Photon Emission Computed Tomography Computed Tomography

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MEDLINE

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RT Journal Article A1 Bensiali M A1 Anizan N A1 Leboulleux S A1 Lamart S A1 Davesne E A1 Broggio D A1 Desbrée A A1 Franck D T1 Patient-specific biokinetics and hybrid 2D/3D approach integration in OEDIPE software: Application to radioiodine therapy. FD Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE YR 2023 VO 113 DO 10.1016/j.ejmp.2022.09.013 SP 102462 JF Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) SN 1724-191X

3D-Ring CZT System With New Low- and Medium-Energy Range: Ultrafast Dual-Isotope Lung SPECT/CT Improvement.

Callaud A;Metrard G;Bailly M

Academic Journal | Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE Please log in to see more details

Abstract: New 3D-ring CZT systems with low- and medium-energy-range detectors allow fo... more

3D-Ring CZT System With New Low- and Medium-Energy Range: Ultrafast Dual-Isotope Lung SPECT/CT Improvement.

Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE

Abstract: New 3D-ring CZT systems with low- and medium-energy-range detectors allow for simultaneous dual-isotope lung scintigraphy. We compared 10-, 7-, 5-, and 3-minute acquisitions for 99m Tc and 81m Kr performed simultaneously on StarGuide CZT-SPECT/CT and reframed in 50 patients. Ventilation/perfusion mismatches were calculated (mean, 15.6% ± 28%), and Spearman correlation coefficients of mismatches were 0.994, 0.994, and 0.984 between 10- and 7-, 5-, and 3-minute acquisitions, respectively. No visual difference in image quality or final diagnosis was found. 3D-ring CZT-SPECT with low and medium energy range detectors allows ultrafast dual-isotope lung scintigraphy up to 3 minutes.
Competing Interests: Conflicts of interest and sources of funding: CHU Orleans received financial and material support from GE Healthcare regarding the StarGuide evaluation. However, the funder (GE Healthcare) was not involved in study design, collection of data, or writing this manuscript. No other potential conflicts of interest relevant to this article exist.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)

Subject terms:

Humans - Tomography, X-Ray Computed - Lung diagnostic imaging - Single Photon Emission Computed Tomography Computed Tomography - Technetium Tc 99m Sestamibi - Tomography, Emission-Computed, Single-Photon methods - Myocardial Perfusion Imaging methods

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MEDLINE

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RT Journal Article A1 Callaud A A1 Metrard G A1 Bailly M T1 3D-Ring CZT System With New Low- and Medium-Energy Range: Ultrafast Dual-Isotope Lung SPECT/CT Improvement. FD Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE YR 2023 VO 48 IS 8 DO 10.1097/RLU.0000000000004706 SP 716 JF Clinical nuclear medicine SN 1536-0229

Impact of bone-equivalent solution density in a thoracic spine phantom on bone single-photon emission computed tomography image quality...

Matsutomo N;Fukami M;Yamamoto T

Academic Journal | Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE Please log in to see more details

This study aimed to evaluate the effects of dipotassium hydrogen phosphate (K more

Impact of bone-equivalent solution density in a thoracic spine phantom on bone single-photon emission computed tomography image quality...

Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE

This study aimed to evaluate the effects of dipotassium hydrogen phosphate (K 2 HPO 4 ) solution density on single-photon emission computed tomography (SPECT) image quality and quantification. We used a JSP phantom containing six cylinders filled with K 2 HPO 4 solutions of varying densities. Computed tomography (CT) was performed, and CT values and linear attenuation coefficients were measured. Subsequently, SPECT images of an SIM 2 bone phantom filled with 99m Tc with/without K 2 HPO 4 solution were acquired using a SPECT/CT camera. The full width at half maximum (FWHM), percentage coefficient of variation (%CV), recovery coefficient, and standardized uptake value (SUV) were evaluated to investigate the impact of the K 2 HPO 4 solution density. The CT values and linear attenuation coefficients increased with the K 2 HPO 4 solution density. The CT values for cancellous and cortical bones were reflected by K 2 HPO 4 solution densities of 0.15-0.20 and 1.50-1.70 g/cm 3 , respectively. FWHM values were significantly lower with the K 2 HPO 4 solution than those with water alone (18.0 ± 0.9 mm with water alone, 15.6 ± 0.2 mm with 0.15 g/cm 3 K 2 HPO 4 , and 16.1 ± 0.3 mm with 1.49 g/cm 3 K 2 HPO 4 ). Although the %CVs showed no significant differences, the recovery coefficients obtained with water alone tended to be slightly lower than those obtained with the K 2 HPO 4 solution. The SUV obtained using the standard density of the K 2 HPO 4 solution differed from that obtained using the optimized density. In conclusion, SPECT image quality and quantification depends on the presence and concentration of the bone-equivalent solution. The optimal bone-equivalent solution density should be used to evaluate the bone image phantoms.
(© 2023. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.)

Subject terms:

Tomography, X-Ray Computed methods - Single Photon Emission Computed Tomography Computed Tomography - Phantoms, Imaging - Tomography, Emission-Computed, Single-Photon methods - Bone Density

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MEDLINE

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RT Journal Article A1 Matsutomo N A1 Fukami M A1 Yamamoto T T1 Impact of bone-equivalent solution density in a thoracic spine phantom on bone <highlight>single</highlight>-<highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight> image quality and quantification. FD Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE YR 2023 VO 16 IS 2 DO 10.1007/s12194-023-00706-5 SP 195 JF Radiological physics and technology SN 1865-0341

An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose.

Brosch-Lenz J;Ke S;Wang H;Frey E;Dewaraja YK;Sunderland J;Uribe C

Academic Journal | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE Please log in to see more details

Dosimetry for personalized radiopharmaceutical therapy has gained considerable attenti... more

An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose.

Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE

Dosimetry for personalized radiopharmaceutical therapy has gained considerable attention. Many methods, tools, and workflows have been developed to estimate absorbed dose (AD). However, standardization is still required to reduce variability of AD estimates across centers. One effort for standardization is the Society of Nuclear Medicine and Molecular Imaging 177 Lu Dosimetry Challenge, which comprised 5 tasks (T1-T5) designed to assess dose estimate variability associated with the imaging protocol (T1 vs. T2 vs. T3), segmentation (T1 vs. T4), time integration (T4 vs. T5), and dose calculation (T5) steps of the dosimetry workflow. The aim of this work was to assess the overall variability in AD calculations for the different tasks. Methods: Anonymized datasets consisting of serial planar and quantitative SPECT/CT scans, organ and lesion contours, and time-integrated activity maps of 2 patients treated with 177 Lu-DOTATATE were made available globally for participants to perform dosimetry calculations and submit their results in standardized submission spreadsheets. The data were carefully curated for formal mistakes and methodologic errors. General descriptive statistics for ADs were calculated, and statistical analysis was performed to compare the results of different tasks. Variability in ADs was measured using the quartile coefficient of dispersion. Results: ADs to organs estimated from planar imaging protocols (T2) were lower by about 60% than those from pure SPECT/CT (T1), and the differences were statistically significant. Importantly, the average differences in dose estimates when at least 1 SPECT/CT acquisition was available (T1, T3, T4, T5) were within ±10%, and the differences with respect to T1 were not statistically significant for most organs and lesions. When serial SPECT/CT images were used, the quartile coefficients of dispersion of ADs for organs and lesions were on average less than 20% and 26%, respectively, for T1; 20% and 18%, respectively, for T4 (segmentations provided); and 10% and 5%, respectively, for T5 (segmentation and time-integrated activity images provided). Conclusion: Variability in ADs was reduced as segmentation and time-integration data were provided to participants. Our results suggest that SPECT/CT-based imaging protocols generate more consistent and less variable results than planar imaging methods. Effort at standardizing segmentation and fitting should be made, as this may substantially reduce variability in ADs.
(© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)

Subject terms:

Humans - Tomography, Emission-Computed, Single-Photon - Radiopharmaceuticals therapeutic use - Radiometry methods - Single Photon Emission Computed Tomography Computed Tomography

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MEDLINE

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RT Journal Article A1 Brosch-Lenz J A1 Ke S A1 Wang H A1 Frey E A1 Dewaraja YK A1 Sunderland J A1 Uribe C T1 An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose. FD Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE YR 2023 VO 64 IS 7 DO 10.2967/jnumed.122.265094 SP 1109 JF Journal of nuclear medicine : official publication, Society of Nuclear Medicine SN 1535-5667

Influence on voxel-based dosimetry: noise effect on absorbed dose dosimetry at single time-point versus sequential single-photon emission computed...

Fonda US;Leitão ALA;Paiva MMDP;Willegaignon J;Josefsson A;Buchpiguel CA;Sap...

Academic Journal | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE Please log in to see more details

Objective: The purpose of this study was to evaluate how statistical fluctuation in si... more

Influence on voxel-based dosimetry: noise effect on absorbed dose dosimetry at single time-point versus sequential single-photon emission computed...

Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE

Objective: The purpose of this study was to evaluate how statistical fluctuation in single-photon emission computed tomography (SPECT) images propagate to absorbed dose maps.
Methods: SPECT/computed tomography (CT) images of iodine-131 filled phantoms, using different acquisition and processing protocols, were evaluated using STRATOS software to assess the absorbed dose distribution at the voxel level. Absorbed dose values and coefficient of variation (COV) were analyzed for dosimetry based on single time-point SPECT images and time-integrated activities of SPECT sequences with low and high counts.
Results: Considering dosimetry based on a single time-point, the mean absorbed dose was not significantly affected by total counts or reconstruction parameters, but the uniformity of the absorbed dose maps had an almost linear correlation with SPECT noise. When high- and low-count SPECT sequences were used to generate an absorbed dose map, the absorbed dose COV for each of the temporal sequences was slightly lower than the absorbed dose COV based on the single SPECT image with the highest count included in the sequence.
Conclusion: The impact of changes in SPECT counts and reconstruction parameters is almost linear when dosimetry is based on isolated SPECT images, but less pronounced when dosimetry is based on sequential SPECTs.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Subject terms:

Single Photon Emission Computed Tomography Computed Tomography - Iodine Radioisotopes - Software - Phantoms, Imaging - Tomography, Emission-Computed, Single-Photon methods - Radiometry methods

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MEDLINE

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RT Journal Article A1 Fonda US A1 Leitão ALA A1 Paiva MMDP A1 Willegaignon J A1 Josefsson A A1 Buchpiguel CA A1 Sapienza MT T1 Influence on voxel-based dosimetry: noise effect on absorbed dose dosimetry at <highlight>single</highlight> time-point versus sequential <highlight>single</highlight>-<highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight>. FD Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE YR 2023 VO 44 IS 7 DO 10.1097/MNM.0000000000001697 SP 596 JF Nuclear medicine communications SN 1473-5628

Sub 4 minute superfast single-photon emission computed tomography/computed tomography as an...

Isherwood AC;Cabral R;Avery G

Academic Journal | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE Please log in to see more details

Whole-body bone scintigraphy remains widely used in nuclear medicine as it is a relati... more

Sub 4 minute superfast single-photon emission computed tomography/computed tomography as an...

Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE

Whole-body bone scintigraphy remains widely used in nuclear medicine as it is a relatively inexpensive and quick test in which the whole body can be imaged with good sensitivity. However, one downside of the technique is its lack of specificity. The difficulty comes when there is a single 'hot spot' which usually requires further anatomical imaging to identify the cause and differentiate malignant from benign lesions. In this situation, hybrid imaging with single-photon emission computed tomography/computed tomography (SPECT/CT) can be a useful problem solver. The addition of SPECT/CT can however, be time-consuming, adding up to 15-20 min for every bed position required, a process that can tax the compliance of the patient and reduce the scanning capacity of the department. We report the successful implementation of a new superfast SPECT/CT protocol comprising a 1 s per view over 24 views point and shoot approach, reducing the SPECT scan time to less than 2 min and the whole SPECT/CT to under 4 min while still producing images that allow diagnostic certainty in previously equivocal lesions. This is faster than previously reported ultrafast SPECT/CT protocols. The utility of the technique is demonstrated in a pictorial review of four disparate causes of solitary bone lesions: fracture, metastasis, degenerative arthropathy and Paget's disease. This technique may prove a cost-effective problem-solving adjunct in nuclear medicine departments unable to yet offer whole-body SPECT/CT to every patient, without adding much burden to the department's gamma camera usage and patient throughput.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Subject terms:

Humans - Tomography, Emission-Computed, Single-Photon methods - Radionuclide Imaging - Bone and Bones diagnostic imaging - Whole Body Imaging - Single Photon Emission Computed Tomography Computed Tomography methods - Bone Neoplasms diagnostic imaging

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MEDLINE

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RT Journal Article A1 Isherwood AC A1 Cabral R A1 Avery G T1 Sub 4 minute superfast <highlight>single</highlight>-<highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight>/<highlight>computed</highlight> <highlight>tomography</highlight> as an add-on for problem-solving in planar bone scintigraphy: a time-saving solution for departments without whole-body <highlight>single</highlight>-<highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight>/<highlight>computed</highlight> <highlight>tomography</highlight>. FD Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE YR 2023 VO 44 IS 5 DO 10.1097/MNM.0000000000001677 SP 407 JF Nuclear medicine communications SN 1473-5628

68 Ga-Oxine-Labeled Erythrocytes as a New PET Tracer for the Localization of Gastrointestinal Bleeding.

Leder T;Kühnel C;Gröber S;Drescher R;Freesmeyer M

Academic Journal | Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE Please log in to see more details

Abstract: A 69-year-old man presented with recurring drops in hemoglobin levels and su... more

68 Ga-Oxine-Labeled Erythrocytes as a New PET Tracer for the Localization of Gastrointestinal Bleeding.

Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE

Abstract: A 69-year-old man presented with recurring drops in hemoglobin levels and suspected gastrointestinal bleeding. Endoscopy did not show a site of bleeding so further examinations became necessary. Scintigraphy and SPECT/CT with 99m TcO 4- -labeled red blood cells were performed without evidence of a hemorrhage. Based on an established protocol for splenic PET/CT, autologous erythrocytes can be labeled with 68 Ga-oxine and used as a tracer for the localization of active bleeding sites. In the patient, PET/CT with 68 Ga-oxine-labeled undamaged erythrocytes was performed successfully and revealed a hemorrhage of the gastric corpus that was confirmed and treated by endoscopy.
Competing Interests: Conflicts of interest and sources of funding: none declared.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Subject terms:

Male - Humans - Aged - Radionuclide Imaging - Single Photon Emission Computed Tomography Computed Tomography - Erythrocytes - Technetium - Positron Emission Tomography Computed Tomography - Gastrointestinal Hemorrhage diagnostic imaging

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MEDLINE

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RT Journal Article A1 Leder T A1 Kühnel C A1 Gröber S A1 Drescher R A1 Freesmeyer M T1 68 Ga-Oxine-Labeled Erythrocytes as a New PET Tracer for the Localization of Gastrointestinal Bleeding. FD Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE YR 2024 VO 49 IS 3 DO 10.1097/RLU.0000000000005021 SP 280 JF Clinical nuclear medicine SN 1536-0229

161 Tb-PSMA Radioligand Therapy: First-in-Humans SPECT/CT Imaging.

Al-Ibraheem A;Doudeen RM;Juaidi D;Abufara A;Maus S

Academic Journal | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE Please log in to see more details

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161 Tb-PSMA Radioligand Therapy: First-in-Humans SPECT/CT Imaging.

Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE

Subject terms:

Humans - Male - Positron Emission Tomography Computed Tomography methods - Prostate-Specific Antigen - Single Photon Emission Computed Tomography Computed Tomography - Tomography, Emission-Computed, Single-Photon methods

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MEDLINE

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RT Journal Article A1 Al-Ibraheem A A1 Doudeen RM A1 Juaidi D A1 Abufara A A1 Maus S T1 <superscript>161</superscript> Tb-PSMA Radioligand Therapy: First-in-Humans SPECT/CT Imaging. FD Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE YR 2023 VO 64 IS 8 DO 10.2967/jnumed.122.265291 SP 1322 JF Journal of nuclear medicine : official publication, Society of Nuclear Medicine SN 1535-5667

Usefulness of phase analysis on ECG gated single photon emission computed tomography myocardial perfusion imaging.

Kuronuma K;Matsumoto N;Van Kriekinge SD;Slomka PJ;Berman DS

Academic Journal | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8804703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4738 (Electronic) Linking ISSN: 09145087 NLM ISO Abbreviation: J Cardiol Subsets: MEDLINE Please log in to see more details

Electrocardiogram (ECG)-gated single photon emission computed tomography myocardial pe... more

Usefulness of phase analysis on ECG gated single photon emission computed tomography myocardial perfusion imaging.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8804703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4738 (Electronic) Linking ISSN: 09145087 NLM ISO Abbreviation: J Cardiol Subsets: MEDLINE

Electrocardiogram (ECG)-gated single photon emission computed tomography myocardial perfusion imaging (GSPECT-MPI) is widely used for assessing coronary artery disease. Phase analysis on GSPECT-MPI can assess left ventricular mechanical dyssynchrony quantitatively on standard GSPECT-MPI alongside myocardial perfusion and function assessment. It has been shown that phase variables by GSPECT-MPI correlate well with tissue Doppler imaging by echocardiography. Main phase variables quantified by GSPECT-MPI are entropy, bandwidth, and phase standard deviation. Although those variables are automatically obtained from several software packages including Quantitative Gated SPECT and Emory Cardiac Toolbox, the methods for their measurement vary in each package. Several studies have shown that phase analysis has predictive value for response to cardiac resynchronization therapy and prognostic value for future adverse cardiac events beyond standard GSPECT-MPI variables. In this review, we summarize the basics of phase analysis on GSPECT-MPI and usefulness of phase analysis in clinical practice.
Competing Interests: Declaration of competing interest S.V.K., P.S., and D.B participate in software royalties for QGS software at Cedars-Sinai Medical Center. D.B. is a consultant for GE Healthcare.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)

Subject terms:

Humans - Tomography, Emission-Computed, Single-Photon methods - Electrocardiography - Heart - Ventricular Dysfunction, Left - Myocardial Perfusion Imaging methods - Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography methods

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MEDLINE

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RT Journal Article A1 Kuronuma K A1 Matsumoto N A1 Van Kriekinge SD A1 Slomka PJ A1 Berman DS T1 Usefulness of phase analysis on ECG gated <highlight>single</highlight> <highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight> myocardial perfusion imaging. FD Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8804703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4738 (Electronic) Linking ISSN: 09145087 NLM ISO Abbreviation: J Cardiol Subsets: MEDLINE YR 2023 VO 82 IS 2 DO 10.1016/j.jjcc.2023.02.008 SP 87 JF Journal of cardiology SN 1876-4738

V/Q SPECT and SPECT/CT in Pulmonary Embolism.

Currie GM;Bailey DL

Academic Journal | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0430303 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5675 (Electronic) Linking ISSN: 00914916 NLM ISO Abbreviation: J Nucl Med Technol Subsets: MEDLINE Please log in to see more details

Ventilation and perfusion (V/Q) lung scintigraphy has been used in the assessment of p... more

V/Q SPECT and SPECT/CT in Pulmonary Embolism.

Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0430303 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5675 (Electronic) Linking ISSN: 00914916 NLM ISO Abbreviation: J Nucl Med Technol Subsets: MEDLINE

Ventilation and perfusion (V/Q) lung scintigraphy has been used in the assessment of patients with suspected pulmonary embolism for more than 50 y. Advances in imaging technology make SPECT and SPECT/CT feasible. This article will examine the application and technical considerations associated with performing 3-dimensional V/Q SPECT and the contribution of a coacquired CT scan. The literature tends to be mixed and contradictory in terms of appropriate investigation algorithms for pulmonary embolism. V/Q SPECT and SPECT/CT offer significant advantages over planar V/Q, with or without the advantages of Technegas ventilation, and if available should be the preferred option in the evaluation of patients with suspected pulmonary embolism.
(© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)

Subject terms:

Humans - Tomography, X-Ray Computed methods - Lung - Single Photon Emission Computed Tomography Computed Tomography - Ventilation-Perfusion Ratio - Tomography, Emission-Computed, Single-Photon methods - Pulmonary Embolism

Content provider:

MEDLINE

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RT Journal Article A1 Currie GM A1 Bailey DL T1 V/Q SPECT and SPECT/CT in Pulmonary Embolism. FD Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0430303 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5675 (Electronic) Linking ISSN: 00914916 NLM ISO Abbreviation: J Nucl Med Technol Subsets: MEDLINE YR 2023 VO 51 IS 1 DO 10.2967/jnmt.122.264880 SP 9 JF Journal of nuclear medicine technology SN 1535-5675

Whole-body single photon emission computed tomography/computed tomography for assessment of...

Komber H;Redman S;Graham R;Anane-Adusei S;Little D

Academic Journal | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE Please log in to see more details

Objectives: Whole-body single photon emission computed tomography/computed tomography ... more

Whole-body single photon emission computed tomography/computed tomography for assessment of...

Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE

Objectives: Whole-body single photon emission computed tomography/computed tomography (WB-SPECT/CT) is useful for diagnosing bone metastases. When performed on a dual-headed gamma camera, this may cover from clavicles to proximal femurs due to time constraints. In contrast, the novel 360 o cadmium-zinc-telluride scanner can perform WB-SPECT/CT (from vertex to toes) in approximately 20 min. The aim was to assess the prevalence of additional findings above the clavicles and below the lesser trochanters and the prevalence of incidental findings in the CT component.
Methods: Retrospective study of 117 WB-SPECT/CT scans for oncological bone assessment over a 4-month-period. Scan analysis was performed by two independent experienced radionuclide radiologists.
Results: The male:female ratio was 71:46 and the mean patient age was 68 years. The primary malignancies were predominantly prostate 65/117 (55.6%) and breast 40/117 (34.2%). There were additional findings of malignancy above the clavicles in 16/116 scans (13.8%) and below the lesser trochanters in 16/117 scans (13.7%). Two cases in the 'above the clavicles' group were suspected solitary metastases, whereas four cases in the 'below lesser trochanters' group were bone metastases at risk of pathological fracture. Incidental findings of clinical significance included suspected new malignancy in 11/117 (9.4%).
Conclusion: A WB-SPECT/CT (from vertex to toes) oncological bone protocol is useful for the detection of additional findings of clinical significance above the clavicles and below the lesser trochanters. Reviewing and reporting the CT findings in SPECT/CT is important.
(Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)

Subject terms:

Humans - Male - Female - Aged - Retrospective Studies - Bone and Bones - Toes - Tomography, Emission-Computed, Single-Photon - Single Photon Emission Computed Tomography Computed Tomography - Bone Neoplasms secondary

Content provider:

MEDLINE

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RT Journal Article A1 Komber H A1 Redman S A1 Graham R A1 Anane-Adusei S A1 Little D T1 Whole-body <highlight>single</highlight> <highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight>/<highlight>computed</highlight> <highlight>tomography</highlight> for assessment of oncological bone disease - is an extended field of view (from vertex to toes) of clinical value? FD Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE YR 2023 VO 44 IS 2 DO 10.1097/MNM.0000000000001647 SP 131 JF Nuclear medicine communications SN 1473-5628

[Three-dimensional Quantitative Evaluation Method in 123 I-MIBG Myocardial SPECT-CT].

Yasumoto Y;Daisaki H;Nakahara T;Ito R;Fujita I

Academic Journal | Publisher: Nihon Hōshasen Gijutsu Gakkai Country of Publication: Japan NLM ID: 7505722 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-4883 (Electronic) Linking ISSN: 03694305 NLM ISO Abbreviation: Nihon Hoshasen Gijutsu Gakkai Zasshi Subsets: MEDLINE Please log in to see more details

Purpose: To distinguish neurodegenerative diseases using 123 more

[Three-dimensional Quantitative Evaluation Method in 123 I-MIBG Myocardial SPECT-CT].

Publisher: Nihon Hōshasen Gijutsu Gakkai Country of Publication: Japan NLM ID: 7505722 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-4883 (Electronic) Linking ISSN: 03694305 NLM ISO Abbreviation: Nihon Hoshasen Gijutsu Gakkai Zasshi Subsets: MEDLINE

Purpose: To distinguish neurodegenerative diseases using 123 I-metaiodobenzylguanidine (MIBG). This study proposes a method to evaluate myocardial standardized uptake value (SUV) and assess its accuracy.
Methods: We created a 17-segment polar map of the myocardial region from single-photon emission computed tomography-computed tomography (SPECT-CT) images using a cardioliver phantom simulating the standard uptake of MIBG. We clarified the optimal reconstruction conditions with good repeatability and accuracy of quantitative values and compared them with the H/M ratio. Myocardial SUVs were evaluated from eight normal cases using our method established from the phantom experiment and compared with the H/M ratio.
Results: The optimal numbers of iterations and subsets in OSEM reconstruction were both 10. The optimal full width at half maximum (FWHM) value of the Gaussian filter was 4 pixels. The RCs and %CV of (1) maximum SUV max (MaxSUV max ) and (2) average SUV max (AveSUV max ) were (1) 36.5% and 4.99%, and (2) 33.6% and 4.84%, respectively. The RC and %CV of the H/M ratio was 15.0% and 1.50%, respectively. In clinical cases, average MaxSUV max and AveSUV max were 8.27 and 7.58, respectively.
Conclusion: Myocardial SUV can provide quantitative values slightly closer to theoretical values than the H/M ratios. Besides, using the optimal reconstruction parameters makes it feasible to quantitatively assess myocardial uptake with good repeatability.

Subject terms:

Single Photon Emission Computed Tomography Computed Tomography - Iodine Radioisotopes - Heart diagnostic imaging - 3-Iodobenzylguanidine - Tomography, Emission-Computed, Single-Photon methods

Content provider:

MEDLINE

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RT Journal Article A1 Yasumoto Y A1 Daisaki H A1 Nakahara T A1 Ito R A1 Fujita I T1 [Three-dimensional Quantitative Evaluation Method in <superscript>123</superscript> I-MIBG Myocardial SPECT-CT]. FD Publisher: Nihon Hōshasen Gijutsu Gakkai Country of Publication: Japan NLM ID: 7505722 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-4883 (Electronic) Linking ISSN: 03694305 NLM ISO Abbreviation: Nihon Hoshasen Gijutsu Gakkai Zasshi Subsets: MEDLINE YR 2023 VO 79 IS 1 DO 10.6009/jjrt.2023-1235 SP 25 JF Nihon Hoshasen Gijutsu Gakkai zasshi SN 1881-4883

Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls.

Ivashchenko OV;O'Doherty J;Hardiansyah D;Cremonesi M;Tran-Gia J;Hippeläinen...

Academic Journal | Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE Please log in to see more details

Absorbed radiation doses are essential in assessing the effects, e.g. safety and effic... more

Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls.

Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE

Absorbed radiation doses are essential in assessing the effects, e.g. safety and efficacy, of radiopharmaceutical therapy (RPT). Patient-specific absorbed dose calculations in the target or the organ at risk require multiple inputs. These include the number of disintegrations in the organ, i.e. the time-integrated activities (TIAs) of the organs, as well as other parameters describing the process of radiation energy deposition in the target tissue (i.e. mean energy per disintegration, radiation dose constants, etc). TIAs are then estimated by incorporating the area under the radiopharmaceutical's time-activity curve (TAC), which can be obtained by quantitative measurements of the biokinetics in the patient (typically based on imaging data such as planar scintigraphy, SPECT/CT, PET/CT, or blood and urine samples). The process of TAC determination/calculation for RPT generally depends on the user, e.g., the chosen number and schedule of measured time points, the selection of the fit function, the error model for the data and the fit algorithm. These decisions can strongly affect the final TIA values and thus the accuracy of calculated absorbed doses. Despite the high clinical importance of the TIA values, there is currently no consensus on processing time-activity data or even a clear understanding of the influence of uncertainties and variations in personalised RPT dosimetry related to user-dependent TAC calculation. As a first step towards minimising site-dependent variability in RPT dosimetry, this work provides an overview of quality assurance and uncertainty management considerations of the TIA estimation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)

Subject terms:

Humans - Single Photon Emission Computed Tomography Computed Tomography - Radiometry methods - Radionuclide Imaging - Radiopharmaceuticals therapeutic use - Positron Emission Tomography Computed Tomography

Content provider:

MEDLINE

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RT Journal Article A1 Ivashchenko OV A1 O'Doherty J A1 Hardiansyah D A1 Cremonesi M A1 Tran-Gia J A1 Hippeläinen E A1 Stokke C A1 Grassi E A1 Sandström M A1 Glatting G T1 Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls. FD Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE YR 2024 VO 117 DO 10.1016/j.ejmp.2023.103192 SP 103192 JF Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) SN 1724-191X

Noninvasive Imaging of Tumor PD-L1 Expression Using [ 99m Tc]Tc-Labeled KN035 with SPECT/CT.

Zhang Y;Ding Y;Li N;Wang S;Zhou S;Li R;Yang H;Li W;Qu J

Academic Journal | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE Please log in to see more details

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) checkpoint blockade is a major b... more

Noninvasive Imaging of Tumor PD-L1 Expression Using [ 99m Tc]Tc-Labeled KN035 with SPECT/CT.

Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) checkpoint blockade is a major breakthrough in cancer therapy, but identifying patients likely to benefit from this therapy remains challenging. Immunohistochemistry is not informative about PD-L1 expression heterogeneity because of the limitations of invasive tissue collection. Noninvasive SPECT imaging is an approach to patient selection and therapeutic monitoring by assessing the PD-L1 status throughout the whole body. Here, we radiolabeled a single-domain PD-L1 antibody with technetium-99m ( 99m Tc) for immune-SPECT imaging to evaluate its feasibility of detecting PD-L1 expression. The radiochemical purity of [ 99m Tc]Tc-HYNIC-KN035 was 99.40 ± 0.11% with a specific activity of 2.68 MBq/μg. [ 99m Tc]Tc-HYNIC-KN035 displayed a high PD-L1 specificity both in vitro and in vivo and showed a high specific affinity for PD-L1 with an equilibrium dissociation constant ( K D ) of 31.04 nM. The binding of [ 99m Tc]Tc-HYNIC-KN035 to H1975 cells (high expression of PD-L1) was much higher than to A549 cells (low expression of PD-L1). SPECT/CT imaging showed that H1975 tumors were visualized at 4 h post-injection and became clearer with time. However, mild tumor uptake was observed in A549 tumors and H1975 tumors of the blocking group at all time points. The uptake value of [ 99m Tc]Tc-HYNIC-KN035 in H1975 tumors was increased continuously from 9.68 ± 0.91% ID/g at 4 h to 13.31 ± 2.23% ID/g at 24 h post-injection, which was higher than in A549 tumors with %ID/g of 4.59 ± 0.76 and 5.54 ± 0.28 at 4 and 24 h post-injection, respectively. These specific bindings were confirmed by blocking studies. [ 99m Tc]Tc-HYNIC-KN035 can be synthesized easily and specifically targeted to PD-L1 in the tumor environment, allowing PD-L1 expression assessment noninvasively and dynamically with SPECT/CT imaging.

Subject terms:

Humans - Cell Line, Tumor - Technetium chemistry - Tomography, Emission-Computed, Single-Photon methods - Neoplasms diagnostic imaging - B7-H1 Antigen metabolism - Single Photon Emission Computed Tomography Computed Tomography

Content provider:

MEDLINE

American Chemical Society Full Text

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RT Journal Article A1 Zhang Y A1 Ding Y A1 Li N A1 Wang S A1 Zhou S A1 Li R A1 Yang H A1 Li W A1 Qu J T1 Noninvasive Imaging of Tumor PD-L1 Expression Using [ <superscript>99m</superscript> Tc]Tc-Labeled KN035 with SPECT/CT. FD Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE YR 2023 VO 20 IS 1 DO 10.1021/acs.molpharmaceut.2c00874 SP 690 JF Molecular pharmaceutics SN 1543-8392

99m Tc-MIP-1404 CZT SPECT/CT versus 68 Ga/PSMA-11 PET/CT: Imaging of prostate cancer metastasis.

Saudi A;Takhar P;Aljabery F;Ochoa-Figueroa M

Academic Journal | Publisher: Elsevier España Country of Publication: Spain NLM ID: 101770941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2253-8089 (Electronic) Linking ISSN: 22538089 NLM ISO Abbreviation: Rev Esp Med Nucl Imagen Mol (Engl Ed) Subsets: MEDLINE Please log in to see more details

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99m Tc-MIP-1404 CZT SPECT/CT versus 68 Ga/PSMA-11 PET/CT: Imaging of prostate cancer metastasis.

Publisher: Elsevier España Country of Publication: Spain NLM ID: 101770941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2253-8089 (Electronic) Linking ISSN: 22538089 NLM ISO Abbreviation: Rev Esp Med Nucl Imagen Mol (Engl Ed) Subsets: MEDLINE

Subject terms:

Male - Humans - Gallium Radioisotopes - Single Photon Emission Computed Tomography Computed Tomography - Positron Emission Tomography Computed Tomography methods - Prostatic Neoplasms diagnostic imaging - Prostatic Neoplasms pathology

Content provider:

MEDLINE

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RT Journal Article A1 Saudi A A1 Takhar P A1 Aljabery F A1 Ochoa-Figueroa M T1 <superscript>99m</superscript> Tc-MIP-1404 CZT SPECT/CT versus <superscript>68</superscript> Ga/PSMA-11 PET/CT: Imaging of prostate cancer metastasis. FD Publisher: Elsevier España Country of Publication: Spain NLM ID: 101770941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2253-8089 (Electronic) Linking ISSN: 22538089 NLM ISO Abbreviation: Rev Esp Med Nucl Imagen Mol (Engl Ed) Subsets: MEDLINE YR 2023 VO 42 IS 6 DO 10.1016/j.remnie.2023.06.003 SP 413 JF Revista espanola de medicina nuclear e imagen molecular SN 2253-8089

A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177 Lu-Peptide Receptor Radionuclide Therapy.

Dewaraja YK;Mirando DM;Peterson AB;Niedbala J;Millet JD;Mikell JK;Frey KA;W...

Academic Journal | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE Please log in to see more details

Patient-specific dosimetry in radiopharmaceutical therapy (RPT) is impeded by the lack... more

A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After 177 Lu-Peptide Receptor Radionuclide Therapy.

Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE

Patient-specific dosimetry in radiopharmaceutical therapy (RPT) is impeded by the lack of tools that are accurate and practical for the clinic. Our aims were to construct and test an integrated voxel-level pipeline that automates key components (organ segmentation, registration, dose-rate estimation, and curve fitting) of the RPT dosimetry process and then to use it to report patient-specific dosimetry in 177 Lu-DOTATATE therapy. Methods: An integrated workflow that automates the entire dosimetry process, except tumor segmentation, was constructed. First, convolutional neural networks (CNNs) are used to automatically segment organs on the CT portion of one post-therapy SPECT/CT scan. Second, local contour intensity-based SPECT--SPECT alignment results in volume-of-interest propagation to other time points. Third, dose rate is estimated by explicit Monte Carlo (MC) radiation transport using the fast, Dose Planning Method code. Fourth, the optimal function for dose-rate fitting is automatically selected for each voxel. When reporting mean dose, we apply partial-volume correction, and uncertainty is estimated by an empiric approach of perturbing segmentations. Results: The workflow was used with 4-time-point 177 Lu SPECT/CT imaging data from 20 patients with 77 neuroendocrine tumors, segmented by a radiologist. CNN-defined kidneys resulted in high Dice values (0.91-0.94) and only small differences (2%-5%) in mean dose when compared with manual segmentation. Contour intensity-based registration led to visually enhanced alignment, and the voxel-level fitting had high R 2 values. Across patients, dosimetry results were highly variable; for example, the average of the mean absorbed dose (Gy/GBq) was 3.2 (range, 0.2-10.4) for lesions, 0.49 (range, 0.24-1.02) for left kidney, 0.54 (range, 0.31-1.07) for right kidney, and 0.51 (range, 0.27-1.04) for healthy liver. Patient results further demonstrated the high variability in the number of cycles needed to deliver hypothetical threshold absorbed doses of 23 Gy to kidney and 100 Gy to tumor. The uncertainty in mean dose, attributable to variability in segmentation, averaged 6% (range, 3%-17%) for organs and 10% (range, 3%-37%) for lesions. For a typical patient, the time for the entire process was about 25 min (∼2 min manual time) on a desktop computer, including time for CNN organ segmentation, coregistration, MC dosimetry, and voxel curve fitting. Conclusion: A pipeline integrating novel tools that are fast and automated provides the capacity for clinical translation of dosimetry-guided RPT.
(© 2022 by the Society of Nuclear Medicine and Molecular Imaging.)

Subject terms:

Humans - Radiometry methods - Radiopharmaceuticals therapeutic use - Tomography, Emission-Computed, Single-Photon - Radioisotopes - Receptors, Peptide - Single Photon Emission Computed Tomography Computed Tomography methods - Neuroendocrine Tumors drug therapy

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RT Journal Article A1 Dewaraja YK A1 Mirando DM A1 Peterson AB A1 Niedbala J A1 Millet JD A1 Mikell JK A1 Frey KA A1 Wong KK A1 Wilderman SJ A1 Nelson AS T1 A Pipeline for Automated Voxel Dosimetry: Application in Patients with Multi-SPECT/CT Imaging After <superscript>177</superscript> Lu-Peptide Receptor Radionuclide Therapy. FD Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE YR 2022 VO 63 IS 11 DO 10.2967/jnumed.121.263738 SP 1665 JF Journal of nuclear medicine : official publication, Society of Nuclear Medicine SN 1535-5667

Evaluation of attenuation correction method for head holder in brain perfusion single-photon emission computed tomography.

Nakashima M;Yamazaki Y

Academic Journal | Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE Please log in to see more details

Head holder attenuation affects brain perfusion single-photon emission computed tomogr... more

Evaluation of attenuation correction method for head holder in brain perfusion single-photon emission computed tomography.

Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE

Head holder attenuation affects brain perfusion single-photon emission computed tomography (SPECT) image quality. Here, we proposed a head holder-attenuation correction (AC) method using attenuation coefficient maps calculated by Chang's method from CT images. Then, we evaluated the effectiveness of the head holder-AC method by numerical phantom and clinical cerebral perfusion SPECT studies. In the numerical phantom, the posterior counts were 10.7% lower than the anterior counts without head holder-AC method. However, by performing head holder-AC, the posterior count recovered by approximately 6.8%, approaching the true value. In the clinical study, the normalized count ratio was significantly increased by performing the head holder-AC method in the posterior-middle cerebral artery, posterior cerebral artery and cerebellum regions. There were no significant increases in other regions. The head holder-AC method can correct the counts attenuated by the head holder.
(© 2024. The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.)

Subject terms:

Phantoms, Imaging - Perfusion - Image Processing, Computer-Assisted - Tomography, Emission-Computed, Single-Photon methods - Brain diagnostic imaging

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MEDLINE

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RT Journal Article A1 Nakashima M A1 Yamazaki Y T1 Evaluation of attenuation correction method for head holder in brain perfusion <highlight>single</highlight>-<highlight>photon</highlight> <highlight>emission</highlight> <highlight>computed</highlight> <highlight>tomography</highlight>. FD Publisher: Springer Japan Country of Publication: Japan NLM ID: 101467995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-0341 (Electronic) Linking ISSN: 18650333 NLM ISO Abbreviation: Radiol Phys Technol Subsets: MEDLINE YR 2024 VO 17 IS 1 DO 10.1007/s12194-024-00778-x SP 322 JF Radiological physics and technology SN 1865-0341

Technical concepts on blood pool phase SPECT (acquisition, reconstruction).

Cade SC;Graham RN

Academic Journal | Publisher: Minerva Medica Country of Publication: Italy NLM ID: 101213861 Publication Model: Print Cited Medium: Internet ISSN: 1827-1936 (Electronic) Linking ISSN: 18244785 NLM ISO Abbreviation: Q J Nucl Med Mol Imaging Subsets: MEDLINE Please log in to see more details

Guidelines for bone scintigraphy are well established and recommend the use of planar ... more

Technical concepts on blood pool phase SPECT (acquisition, reconstruction).

Publisher: Minerva Medica Country of Publication: Italy NLM ID: 101213861 Publication Model: Print Cited Medium: Internet ISSN: 1827-1936 (Electronic) Linking ISSN: 18244785 NLM ISO Abbreviation: Q J Nucl Med Mol Imaging Subsets: MEDLINE

Guidelines for bone scintigraphy are well established and recommend the use of planar early phase images to investigate a number of clinical indications. With recent advances in gamma camera technology the use of SPECT/CT imaging in the early phases is now possible, offering the potential of improved diagnostic confidence and prognostic value. To date little work has been carried out to optimize the acquisition of early phase bone images using SPECT/CT with most of the available studies acquiring SPECT images after the traditional planar images to allow comparison of the two techniques. Imaging durations of 7 to 10 minutes have been commonly used. However, the use of iterative reconstruction algorithms has been investigated with rapid SPECT imaging to allow imaging durations as low as 4 minutes. The use of CZT based systems with increased sensitivity and improved energy and spatial resolution also offers the potential to reduce imaging times. The optimization of projection measurement order has been investigated as a method of reducing image artefacts as a result of changing tracer distribution during the SPECT acquisition. In this article we consider the current state of early phase SPECT imaging and possible areas for future investigation as well as recommendations for departments looking to adopt blood pool SPECT imaging as part of their routine clinical practice.

Subject terms:

Humans - Tomography, X-Ray Computed - Algorithms - Artifacts - Tomography, Emission-Computed, Single-Photon - Single Photon Emission Computed Tomography Computed Tomography

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MEDLINE

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RT Journal Article A1 Cade SC A1 Graham RN T1 Technical concepts on blood pool phase SPECT (acquisition, reconstruction). FD Publisher: Minerva Medica Country of Publication: Italy NLM ID: 101213861 Publication Model: Print Cited Medium: Internet ISSN: 1827-1936 (Electronic) Linking ISSN: 18244785 NLM ISO Abbreviation: Q J Nucl Med Mol Imaging Subsets: MEDLINE YR 2023 VO 67 IS 3 DO 10.23736/S1824-4785.23.03506-9 SP 183 JF The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.. SN 1827-1936

The role of 99m Tc-DPD bone SPECT/CT in the management of growth disturbance of the long bones in pediatric patients: a retrospective observational study.

Shin CH;Whi W;Cho YJ;Yoo WJ;Choi IH;Cheon GJ;Cho TJ

Academic Journal | Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE Please log in to see more details

Backgrounds: Determining the precise localization of diseased physes is crucial for gu... more

The role of 99m Tc-DPD bone SPECT/CT in the management of growth disturbance of the long bones in pediatric patients: a retrospective observational study.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE

Backgrounds: Determining the precise localization of diseased physes is crucial for guiding the treatment of growth disturbances. Conventional radiography, computed tomography (CT), and magnetic resonance imaging only provide information on physeal anatomy. Planar bone scintigraphy and bone single-photon emission computed tomography (SPECT) resolutions are suboptimal for clinically managing growth disturbances. Bone SPECT/CT, which provides high-resolution functional information, can be a useful tool for evaluating growth disturbances. The purposes of this study were to identify the conditions in which bone SPECT/CT outperforms planar scintigraphy or SPECT for evaluating the location and activity of diseased physes and to assess surgical outcomes using bone SPECT/CT findings in pediatric patients experiencing long bone growth disturbances.
Methods: Fifty-nine patients who underwent bone SPECT/CT between January 2018 and January 2021 to evaluate physeal activity using technetium-99 m-labeled 2,3-dicarboxypropane-1,1-diphosphonate ( 99m Tc-DPD) were included. The proportions of patients for whom certain modalities provided sufficient data for selecting treatment plans for growth disturbances were compared based on the site of the diseased physis, growth disturbance cause, and shape of deformity (i.e., SPECT/CT vs. planar scintigraphy and SPECT/CT vs. SPECT). For assessing surgical outcomes, progression of post-surgical deformity was investigated by measuring the angles reflecting the degree of deformity, iliac crest height difference, or ulnar variance on radiographs.
Results: Bone SPECT/CT was sufficient for selecting a treatment plan, but planar scintigraphy or SPECT alone was insufficient in every 10 patients with diseased physes inside the femoral head (p = 0.002) and in every six with physes that were severely deformed or whose locations were unclear on conventional radiography (p = 0.03). In the proximal or distal tibia, where the tibial and fibular physes often overlapped on planar scintigraphy due to leg rotation, bone SPECT/CT was sufficient in 33/34 patients (97%), but planar scintigraphy and SPECT were sufficient in 10/34 (29%) (p < 0.001) and 24/34 (71%) patients, respectively (p = 0.004). No progression or deformity recurrence occurred.
Conclusions: Bone SPECT/CT may be indicated in proximal femoral growth disturbance, when the physis is unclear on conventional radiography or severely deformed, the leg exhibits rotational deformity, or the patient is noncompliant.
(© 2023. BioMed Central Ltd., part of Springer Nature.)

Subject terms:

Humans - Child - Tomography, X-Ray Computed - Bone Development - Diphosphonates therapeutic use - Single Photon Emission Computed Tomography Computed Tomography - Tomography, Emission-Computed, Single-Photon

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MEDLINE

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RT Journal Article A1 Shin CH A1 Whi W A1 Cho YJ A1 Yoo WJ A1 Choi IH A1 Cheon GJ A1 Cho TJ T1 The role of <superscript>99m</superscript> Tc-DPD bone SPECT/CT in the management of growth disturbance of the long bones in pediatric patients: a retrospective observational study. FD Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE YR 2023 VO 24 IS 1 DO 10.1186/s12891-023-06777-0 SP 668 JF BMC musculoskeletal disorders SN 1471-2474

Quantitative analysis of liver standardized uptake value repeatability in SPECT/CT implications for clinical practice.

Tokorodani R;Kume T;Daisaki H;Hayashi N;Iwasa H;Yamagami T

Academic Journal | Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE Please log in to see more details

Purpose . The aim of this study was to assess the repeatability of the SUV normalized ... more

Quantitative analysis of liver standardized uptake value repeatability in SPECT/CT implications for clinical practice.

Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE

Purpose . The aim of this study was to assess the repeatability of the SUV normalized by liver volume (SUVL) between two liver receptor SPECT/CT studies performed on different days in patients with ICG-R15 values within normal range. Methods . 935 patients who underwent liver receptor scintigraphy between January 2010 and August 2018 were included. Patients who underwent liver resection, hepatic arterial embolization or had ICG-R15 >10% between scans were excluded, and 38 patients were finally included in the analysis. The repeatability of SUVL between scans was assessed using the intraclass correlation coefficient (ICC) (1.1) between SUVLmax, SUVLpeak and SUVLmean at the first and second scan and the additive and proportional errors from the Bland-Altman analysis. Results . In ICC (1,1), SUVLmax, SUVLpeak and SUVLmean were all greater than 0.8, indicating almost perfect repeatability; neither additive nor proportional errors were observed in the Bland-Altman analysis. Conclusions . In patients with ICG-R15 values within the normal range, the SUV Liver (SUVL) between two liver receptor SPECT/CT studies performed on different days was repeatability over time. It was suggested that the SUVL of liver receptor scintigraphy could be an indicator that could be used for follow-up over time in the assessment of liver fibrosis.
(© 2024 IOP Publishing Ltd.)

Subject terms:

Humans - Liver diagnostic imaging - Single Photon Emission Computed Tomography Computed Tomography

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MEDLINE

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RT Journal Article A1 Tokorodani R A1 Kume T A1 Daisaki H A1 Hayashi N A1 Iwasa H A1 Yamagami T T1 Quantitative analysis of liver standardized uptake value repeatability in SPECT/CT implications for clinical practice. FD Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE YR 2024 VO 10 IS 3 DO 10.1088/2057-1976/ad3759 JF Biomedical physics & engineering express SN 2057-1976

Reply to Giovanni Lughezzani, Paolo Casale, and Laura Evangelista's Letter to the Editor re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99m Tc-Sestamibi Single-photon...

Basile G;Gallioli A;Chiti A;Capitanio U;Breda A

Report | Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE Please log in to see more details

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Reply to Giovanni Lughezzani, Paolo Casale, and Laura Evangelista's Letter to the Editor re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of 99m Tc-Sestamibi Single-photon...

Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE

Subject terms:

Humans - Single Photon Emission Computed Tomography Computed Tomography - Technetium Tc 99m Sestamibi

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MEDLINE

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RT Journal Article A1 Basile G A1 Gallioli A A1 Chiti A A1 Capitanio U A1 Breda A T1 Reply to Giovanni Lughezzani, Paolo Casale, and Laura Evangelista's Letter to the Editor re: Giuseppe Basile, Giuseppe Fallara, Paolo Verri, et al. The Role of <superscript>99m</superscript> Tc-Sestamibi <highlight>Single</highlight>-<highlight>photon</highlight> <highlight>Emission</highlight> <highlight>Computed</highlight> <highlight>Tomography</highlight>/<highlight>Computed</highlight> <highlight>Tomography</highlight> in the Diagnostic Pathway for Renal Masses: A Systematic Review and Meta-analysis. Eur Urol. 2024;85:63-71. FD Publisher: Elsevier Science Country of Publication: Switzerland NLM ID: 7512719 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7560 (Electronic) Linking ISSN: 03022838 NLM ISO Abbreviation: Eur Urol Subsets: MEDLINE YR 2024 VO 85 IS 3 DO 10.1016/j.eururo.2023.11.021 SP e77 JF European urology SN 1873-7560

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