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The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
Anne Kristin McLaren Berge;Juncal Garcia-Garcia;Eva Sjøttem;Hallvard Laurit...
Mitochondria are the center for energy production, cell fate determination and synthes...
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The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
Autophagy Reports, Vol 2, Iss 1 (2023)
Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria through lysosomal degradation. The triggering of mitophagy can be either ubiquitin dependent or ubiquitin independent. Ubiquitin-dependent mitophagy relies on ubiquitin as a signal on the surface of dysfunctional mitochondria. PRKN/PARKIN is the ubiquitin E3 ligase of the well described PINK1-PRKN-dependent mitophagy. However, other ubiquitin-dependent mitophagy pathways that are independent of PRKN are emerging, but little is known about which ubiquitin E3 ligases are implicated. We shall here discuss our recent identification of the ubiquitin E3 ligase TRIM27 (tripartite motif containing 27) as a player in PINK1-PRKN-independent mitophagy. We will focus on the concerted action of TRIM27, the autophagy receptor SQSTM1/p62 and TBK1 (TANK binding kinase 1), which leads to mitochondrial clustering and enhanced mitophagy. We propose a model where a TRIM27-SQSTM1/p62-TBK1 pathway acts as an alternative or compensatory pathway for the PINK1-PRKN pathway to induce ubiquitin-dependent mitophagy.
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e3 ligase - mitophagy - sqstm1/p62 - tbk1 - trim - Cytology - QH573-671Content provider:
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Performing grief : bridal laments in rural China / Anne E. McLaren.
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2008
Available at Available Merrill-Cazier Books (2nd Floor South) (Call number: GT 2783 .A2 M35 2008)
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Animal applications of research in mammalian development / edited by Roger A. Pedersen, Anne McLaren, Neal First.
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1991
Available at Available Merrill-Cazier Books (4th Floor North) (Call number: SF767.5 .A55 1991)
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| Merrill-Cazier Books (4th Floor North) | SF767.5 .A55 1991 | Available |
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Chimeras in developmental biology / edited by Nicole Le Douarin, Anne McLaren.
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1984
Available at Available Merrill-Cazier BARN, Books, Circulation Desk (1st Floor) (Call number: QL 971 .C48 1984)
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| Merrill-Cazier BARN, Books, Circulation Desk (1st Floor) | QL 971 .C48 1984 | Available |
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Passion, Poverty and Travel: Traditional Hakka Songs and Ballads, Wilt L. Idema
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2016 China Q. 1142 (2016) / China Quarterly, Vol. 2016, Issue 228 (December 2016), pp. 1142-1143
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McLaren, Anne E.
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2016 China Q. 1142 (2016) / China Quarterly, Vol. 2016, Issue 228 (December 2016), pp. 1142-1143
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Germ cells and soma : a new look at an old problem / Anne McLaren.
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1981
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Development and performance of a point-of-care rapid antigen test for detection of SARS-COV-2 variants
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Journal of Clinical Virology Plus, Vol 2, Iss 3, Pp 100080- (2022)
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Lihong Liu;Kathrine Meyers;Lawrence J. Purpura;Nadia Nguyen;Hiroshi Mohri;J...
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Journal of Clinical Virology Plus, Vol 2, Iss 3, Pp 100080- (2022)
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Background: SARS-CoV-2 antigen-based tests are well-calibrated to infectiousness and h...
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Development and performance of a point-of-care rapid antigen test for detection of SARS-COV-2 variants
Journal of Clinical Virology Plus, Vol 2, Iss 3, Pp 100080- (2022)
Background: SARS-CoV-2 antigen-based tests are well-calibrated to infectiousness and have a critical role to play in the COVID-19 public health response. We report the development and performance of a unique lateral flow immunoassay (LFA). Methods: Combinations of several monoclonal antibodies targeting multiple antigenic sites on the SARS-CoV-2 nucleocapsid protein (NP) were isolated, evaluated, and chosen for the development of a LFA termed CoV-SCAN (BioMedomics, Inc.). Clinical point-of-care studies in symptomatic and asymptomatic individuals were conducted to evaluate positive predictive agreement (PPA) and negative predictive agreement (NPA) with RT-PCR as comparator. Results: In laboratory testing, CoV-SCAN detected 14 recombinant N-proteins of SARS-CoV-2 variants with sensitivity in the range of 0.2–3.2 ng/mL, and 10 authentic SARS-CoV-2 variants with sensitivity in the range of 1.6–12.5 TCID50/swab. No cross reactivity was observed with other human coronaviruses or other respiratory pathogens. In clinical point-of-care testing on 148 individuals over age 2 with symptoms of ≤5 days, PPA was 87.2% (CI 95: 78.3–94.8%) and NPA was 100% (CI 95: 94.2–100%). In another 884 asymptomatic individuals, PPA was 85.7% (CI 95: 42.1–99.6%) and 99.7% (99.0–99.9%). Overall, CoV-SCAN detected over 97.2% of specimens with CT values
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SARS-CoV-2 rapid antigen tests - COVID-19 - Variants of concern (VOCs) - Cross-reactivity - Infectious and parasitic diseases - RC109-216Content provider:
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Advances in reproductive physiology.
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1966 - 1973
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Available at Merrill-Cazier BARN, Books, Circulation Desk (1st Floor) (QP 251 .A3 V.1) plus 5+ more
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Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank
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Molecular Autism, Vol 12, Iss 1, Pp 1-17 (2021)
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Chloe X. Yap;Gail A. Alvares;Anjali K. Henders;Tian Lin;Leanne Wallace;Alai...
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Molecular Autism, Vol 12, Iss 1, Pp 1-17 (2021)
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Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental con...
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Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank
Molecular Autism, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose biological basis is yet to be elucidated. The Australian Autism Biobank (AAB) is an initiative of the Cooperative Research Centre for Living with Autism (Autism CRC) to establish an Australian resource of biospecimens, phenotypes and genomic data for research on autism. Methods Genome-wide single-nucleotide polymorphism genotypes were available for 2,477 individuals (after quality control) from 546 families (436 complete), including 886 participants aged 2 to 17 years with diagnosed (n = 871) or suspected (n = 15) ASD, 218 siblings without ASD, 1,256 parents, and 117 unrelated children without an ASD diagnosis. The genetic data were used to confirm familial relationships and assign ancestry, which was majority European (n = 1,964 European individuals). We generated polygenic scores (PGS) for ASD, IQ, chronotype and height in the subset of Europeans, and in 3,490 unrelated ancestry-matched participants from the UK Biobank. We tested for group differences for each PGS, and performed prediction analyses for related phenotypes in the AAB. We called copy-number variants (CNVs) in all participants, and intersected these with high-confidence ASD- and intellectual disability (ID)-associated CNVs and genes from the public domain. Results The ASD (p = 6.1e−13), sibling (p = 4.9e−3) and unrelated (p = 3.0e−3) groups had significantly higher ASD PGS than UK Biobank controls, whereas this was not the case for height—a control trait. The IQ PGS was a significant predictor of measured IQ in undiagnosed children (r = 0.24, p = 2.1e−3) and parents (r = 0.17, p = 8.0e−7; 4.0% of variance), but not the ASD group. Chronotype PGS predicted sleep disturbances within the ASD group (r = 0.13, p = 1.9e−3; 1.3% of variance). In the CNV analysis, we identified 13 individuals with CNVs overlapping ASD/ID-associated CNVs, and 12 with CNVs overlapping ASD/ID/developmental delay-associated genes identified on the basis of de novo variants. Limitations This dataset is modest in size, and the publicly-available genome-wide-association-study (GWAS) summary statistics used to calculate PGS for ASD and other traits are relatively underpowered. Conclusions We report on common genetic variation and rare CNVs within the AAB. Prediction analyses using currently available GWAS summary statistics are largely consistent with expected relationships based on published studies. As the size of publicly-available GWAS summary statistics grows, the phenotypic depth of the AAB dataset will provide many opportunities for analyses of autism profiles and co-occurring conditions, including when integrated with other omics datasets generated from AAB biospecimens (blood, urine, stool, hair).
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Autism spectrum disorder - Genetics - Polygenic score - Copy number variation - Australian autism biobank - Neurology. Diseases of the nervous system - RC346-429Content provider:
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Singing on the River: Sichuan Boatmen and Their Work Songs, 1880s–1930s by Igor Iwo Chabrowski (review)
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CHINOPERL: Journal of Chinese Oral and Performing Literature. 36(1):82-87
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Mclaren, Anne E.
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CHINOPERL: Journal of Chinese Oral and Performing Literature. 36(1):82-87
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Western Han: A Yangzhou Storyteller’s Script ed. by Vibeke Børdahl, Liangyan Ge (review)
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CHINOPERL: Journal of Chinese Oral and Performing Literature. 37(1):75-79
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McLaren, Anne E.
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CHINOPERL: Journal of Chinese Oral and Performing Literature. 37(1):75-79
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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol
Katie Ross;Dimitra Fleming;John Marshall;Najib Ayas;François Lellouche;Just...
Introduction Ventilator-associated pneumonia (VAP) is a common healthcare-associated i...
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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol
BMJ Open, Vol 10, Iss 6 (2020)
Introduction Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and Clostridioides difficile–associated diarrhoea (CDAD). PROSPECT (Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial) is a multicentre, double-blinded, randomised controlled trial comparing the efficacy of the probiotic Lactobacillus rhamnosus GG with usual care versus usual care without probiotics in preventing VAP and other clinically important outcomes in critically ill patients admitted to the ICU.Methods and analysis The objective of E-PROSPECT is to determine the incremental cost-effectiveness of L. rhamnosus GG plus usual care versus usual care without probiotics in critically ill patients. E-PROSPECT will be performed from the public healthcare payer’s perspective over a time horizon from ICU admission to hospital discharge.We will determine probabilities of in-ICU and in-hospital events from all patients alongside PROSPECT. We will retrieve unit costs for each resource use item using jurisdiction-specific public databases, supplemented by individual site unit costs if such databases are unavailable. Direct costs will include medications, personnel costs, radiology/laboratory testing, operative/non-operative procedures and per-day hospital ‘hoteling’ costs not otherwise encompassed. The primary outcome is the incremental cost per VAP prevented between the two treatment groups. Other clinical events such as CDAD, antibiotic-associated diarrhoea and in-hospital mortality will be included as secondary outcomes. We will perform pre-specified subgroup analyses (medical/surgical/trauma; age; frailty status; antibiotic use; prevalent vs no prevalent pneumonia) and probabilistic sensitivity analyses for VAP, then generate confidence intervals using the non-parametric bootstrapping approach.Ethics and dissemination Study approval for E-PROSPECT was granted by the Hamilton Integrated Research Ethics Board of McMaster University on 29 July 2019. Informed consent was obtained from the patient or substitute decision-maker in PROSPECT. The findings of this study will be published in peer-reviewed journals.Trial registration number NCT01782755; Pre-results.
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