Encore -- :(Phage display)

Additional actions:

Phage display : a laboratory manual / by Carlos F. Barbas III ... [and others].

Book | 2001

Available at Available Merrill-Cazier Books (3rd Floor North) (Call number: QR 342 .P454 2001)

close

see all

Items

Location	Call No.	Status
Merrill-Cazier Books (3rd Floor North)	QR 342 .P454 2001	Available

Additional actions:

Phage Display's Prospects for Early Diagnosis of Prostate Cancer.

Petrenko, Valery A.

Academic Journal | Viruses (1999-4915). Feb2024, Vol. 16 Issue 2, p277. 16p. Please log in to see more details

Additional actions:

Phage display in biotechnology and drug discovery / edited by Sachdev S. Sidhu, Clarence Ronald Geyer.

Ebook | 2015

Additional actions:

Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform.

Zhang, Tiantian;Wang, Zhe

Academic Journal | Biologics. Mar2024, Vol. 4 Issue 1, p55-74. 20p. Please log in to see more details

Additional actions:

Phage display as a tool for synthetic biology [electronic resource] / Santina Carnazza and Salvatore Guglielmino.

Carnazza, Santina.

Ebook | 2010

Available online; click to view.

Additional actions:

Screening TLR4 Binding Peptide from Naja atra Venom Glands Based on Phage Display.

Li, Runhan;Tang, Yezhong;Chen, Zening;Liu, Yang

Academic Journal | Toxins. Mar2024, Vol. 16 Issue 3, p113. 15p. Please log in to see more details

Additional actions:

Phage display in biotechnology and drug discovery / edited by Sachdev S. Sidhu.

Book | 2005

Available at Available Merrill-Cazier Books (3rd Floor North) (Call number: QR 342 .P4555 2005)

close

see all

Items

Location	Call No.	Status
Merrill-Cazier Books (3rd Floor North)	QR 342 .P4555 2005	Available

Additional actions:

Generation of a helper phage for the fluorescent detection of peptide-target interactions by dual-display phages.

De Plano, Laura Maria;Oddo, Salvatore;Guglielmino, Salvatore P. P.;Caccamo,...

Academic Journal | Scientific Reports. 11/2/2023, Vol. 13 Issue 1, p1-11. 11p. Please log in to see more details

Additional actions:

IgY-Technology: Production and Application of Egg Yolk Antibodies [electronic resource] : Basic Knowledge for a Successful Practice / edited by Xiao-Ying Zhang, Ricardo S. Vieira-Pires, Patricia M. Morgan, Rüdiger Schade.

Ebook | 2021

Available online; click to view.

Additional actions:

Generation of Endotoxin-Specific Monoclonal Antibodies by Phage and Yeast Display for Capturing Endotoxin.

Fux, Alexandra C.;Casonato Melo, Cristiane;Schlahsa, Laura;Burzan, Nico B.;...

Academic Journal | International Journal of Molecular Sciences. Feb2024, Vol. 25 Issue 4, p2297. 19p. Please log in to see more details

Additional actions:

Recombinant Antibodies for Infectious Diseases [electronic resource] / edited by Theam Soon Lim.

Ebook | 2017

Available online; click to view.

Additional actions:

Construction of a Human Immune Library from Gallbladder Cancer Patients for the Single-Chain Fragment Variable (scFv) Antibody Selection against Claudin 18.2 via Phage Display.

Effer, Brian;Ulloa, Daniel;Dappolonnio, Camila;Muñoz, Francisca;Iturrieta-G...

Academic Journal | Antibodies (2073-4468). Mar2024, Vol. 13 Issue 1, p20. 15p. Please log in to see more details

Additional actions:

Immunoassays : development, applications and future trends / edited by Richard O'Kennedy, Caroline Murphy.

Ebook | 2017

Additional actions:

Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform

Tiantian Zhang;Zhe Wang

Academic Journal | Biologics, Vol 4, Iss 1, Pp 55-74 (2024) Please log in to see more details

Thirty-four years ago, the groundbreaking work of John McCafferty and Sir Gregory Wint... more

Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform

Biologics, Vol 4, Iss 1, Pp 55-74 (2024)

Thirty-four years ago, the groundbreaking work of John McCafferty and Sir Gregory Winter in developing phage display technology revolutionized the discovery of human antibodies, paving the way for diverse applications. Since then, numerous phage-derived antibodies have been successfully developed and advanced into clinical studies, resulting in the approval of more than a dozen therapeutic antibodies. These antibodies have demonstrated efficacy across a spectrum of medical conditions, ranging from autoimmune diseases to various cancers. In this article, we provide an in-depth review of the development of phage display libraries as powerful platforms for therapeutic antibody discovery, elucidating the intricate procedures involved in antibody development. Additionally, we conduct a review of the current ntibody drugs for cancer treatment that have been developed using the phage display platform. Furthermore, we discuss the challenges inherent in this technology, offering insights into potential solutions to enhance crucial steps and facilitate more efficient drug discovery in the field of phage display technology.

Subject terms:

phage display library - cancer treatment - antibody development - Biology (General) - QH301-705.5

Content provider:

Directory of Open Access Journals

View record in DOAJ

Additional actions:

Nanotherapeutics : from laboratory to clinic / Ezharul H. Chowdhury.

Chowdhury, Ezharul Hoque, author.

Ebook | 2016

Additional actions:

Screening Peptide-Binding Partners for GenX via Phage Display.

Burton, Kameron;Ghadami, Samaneh;Dellinger, Kristen;Wang, Bo;Dong, Ming

Academic Journal | International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 5, p2686. 8p. Please log in to see more details

Additional actions:

Bio-inspired materials and micro/nanostructures enabled by peptides and proteins / Swathi Swaminathan.

Swaminathan, Swathi, author.

Ebook | 2015

Available at Available Online freely available USU Digital Resources (USU and USU Eastern) (Call number: ELECTRONIC THESIS/DISSERTATION)

close

see all

Items

Location	Call No.	Status
Online freely available USU Digital Resources (USU and USU Eastern)	ELECTRONIC THESIS/DISSERTATION	Available

Available Online

Additional actions:

Progress on Phage Display Technology: Tailoring Antibodies for Cancer Immunotherapy.

França, Renato Kaylan Alves;Studart, Igor Cabral;Bezerra, Marcus Rafael Lob...

Academic Journal | Viruses (1999-4915). Sep2023, Vol. 15 Issue 9, p1903. 26p. Please log in to see more details

Additional actions:

Viral diagnostics : advances and applications / edited by Robert S. Marks, Leslie Lobel, Amadou Alpha Sall.

Ebook | 2013

Additional actions:

Beckman Research Institute City of Hope Researcher Discusses Research in Display Technology (Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Pla...

Periodical | Obesity, Fitness & Wellness Week. March 16, 2024, 1300 Please log in to see more details

Check for Full Text

Additional actions:

Bacteriophages in health and disease / edited by Paul Hyman and Stephen T. Abedon.

Book | 2012

Available at Available Merrill-Cazier Books (3rd Floor North) (Call number: QR342 .B33 2012)

close

see all

Items

Location	Call No.	Status
Merrill-Cazier Books (3rd Floor North)	QR342 .B33 2012	Available

Additional actions:

Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display

Mahmoud Ganji;Pooria Safarzadeh Kozani;Fatemeh Rahbarizadeh

Academic Journal | Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023) Please log in to see more details

Abstract Background Monoclonal antibody (mAb)-based immunotherapies have achieved prom... more

Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display

Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-20 (2023)

Abstract Background Monoclonal antibody (mAb)-based immunotherapies have achieved promising outcomes in the treatment of immunological and oncological indications. CD19 is considered one of the most qualified antigens in the treatment of B-cell neoplasms. VHHs (nanobodies) are known for their physicochemical advantages over conventional mAbs rendering them suitable therapeutics and diagnostic tools. Herein, we aimed to isolate CD19-specific VHHs from a novel immune library using phage display. Methods An immune VHH gene library was constructed. Using phage display and after five biopanning rounds, two monoclonal CD19-specific VHHs were isolated. The selected VHHs were expressed, purified, and characterized in terms of their affinity, specificity, sensitivity, and ability to target CD19-positive cell lines. Moreover, in silico analyses were employed for further characterization. Results A VHH library was developed, and because the outputs of the 4th biopanning round exhibited the most favorable characteristics, a panel of random VHHs was selected from them. Ultimately, two of the most favorable VHHs were selected and DNA sequenced (designated as GR37 and GR41). Precise experiments indicated that GR37 and GR41 exhibited considerable specificity, sensitivity, and affinity (1.15 × 107 M−1 and 2.08 × 107 M−1, respectively) to CD19. Flow cytometric analyses revealed that GR37 and GR41 could bind CD19 on the surface of cell lines expressing the antigen. Moreover, in silico experiments predicted that both VHHs target epitopes that are distinct from that targeted by the CD19-specific single-chain variable fragment (scFv) FMC63. Conclusion The selected VHHs can be used as potential targeting tools for the development of CD19-based immunotherapeutics.

Subject terms:

CD19 - Cancer immunotherapy - VHH - Nanobody - mAb - Phage display - Medicine

Content provider:

Directory of Open Access Journals

View record in DOAJ

Additional actions:

Protein engineering and design / edited by Sheldon J. Park, Jennifer R. Cochran.

Ebook | 2010