Item Display - Sequence alignment : methods, models, concepts, and strategies

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  Title

  Sequence alignment : methods, models, concepts, and strategies

  Author

  Rosenberg, Michael S., 1972-  

  Publisher:

  University of California Press,

  Pub date:

  ©2009.

  Physical Description

  1 online resource (xvi, 337 pages) :

  ISBN:

  9780520943742

  Item info:

  1 copy available at MUT Main Lib..
  

  • 9780520943742
    
  • Holdings			Change Display
    MUT Main Lib.
    	Copy	Material	Location
    QH324.2 .S47 2009 EB	1	Electronic Book	Online

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  Sequence alignment : methods, models, concepts, and strategies
  Rosenberg, Michael S., 1972-
  
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• MARC Record

  Sequence alignment : methods, models, concepts, and strategies
  Rosenberg, Michael S., 1972-
  

  ISBN:

  9780520943742 (electronic bk.)

  ISBN:

  0520943740 (electronic bk.)

  ISBN:

  (ISBN invalid)9780520256972

  ISBN:

  (ISBN invalid)0520256972

  ISBN:

  (ISBN invalid)9780520271319

  Local system #:

  (OCoLC)574421194 (OCoLC)499452367 (OCoLC)536166697 (OCoLC)816343740

  Dewey Decimal Classification Number:

  572.80285 22

  Title:

  Sequence alignment : methods, models, concepts, and strategies / edited by Michael S. Rosenberg.

  Publication info:

  Berkeley : University of California Press, ©2009.

  Physical descript:

  1 online resource (xvi, 337 pages) : illustrations

  Content Type:

  text txt

  Media carrier:

  computer c

  Carrier Type:

  online resource cr

  Bibliography note:

  Includes bibliographical references (pages 297-332) and index.

  Contents:

  Sequence alignment : concepts and history -- Insertion and deletion events, their molecular mechanisms, and their impact on sequence alignments -- Local versus global alignments -- Computing multiple sequence alignment with template-based methods -- Sequence evolution models for simultaneous alignment and phylogeny reconstruction -- Phylogenetic hypotheses and the utility of multiple sequence alignment -- Structural and evolutionary considerations for multiple sequence alignment of RNA, and the challenges for algorithms that ignore them -- Constructing alignment benchmarks -- Simulation approaches to evaluating alignment error and methods for comparing alternate alignments -- Robust inferences from ambiguous alignments -- Strategies for efficient exploitation of the informational content of protein multiple alignments.

  Abstract/summary:

  The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences-making sure that sequences from one source are properly compared to those from other sources-remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted.

  Subject term:

  Bioinformatics.

  Subject term:

  Computational biology.

  Subject term:

  Sequence alignment (Bioinformatics)

  Genre index term:

  Electronic books.

  Added Entry-Personal Name:

  Rosenberg, Michael S., 1972-

  HTTP:

  http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=305982