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  '''Tetrahydrocannabinol''' ({{IPAc-en|icon|ˌ|t|ɛ|t|r|ə|ˌ|h|aɪ|d|r|ɵ|k|ə|ˈ|n|æ|b|ɨ|n|ɒ|l}} {{Respell|tet-rə|HY|drə-kə|NAB|i-nol}}; '''THC'''), also known as '''delta-9-tetrahydrocannabinol''' ('''Δ<sup>9</sup>-THC'''), is the principal [[psychoactive drug|psychoactive constituent]] of the [[cannabis]] plant. First isolated in 1964,<ref name="doi10.1021/ja01062a046">{{cite journal |doi=10.1021/ja01062a046 |year=1964 |last1=Gaoni |first1=Y. |last2=Mechoulam |first2=R. |journal=Journal of the American Chemical Society |volume=86 |issue=8 |pages=1646–1647}}</ref><ref>[http://matters.ecnp.nl/number11/interview2.shtml Interview with the winner of the first ECNP Lifetime Achievement Award: Raphael Mechoulam, Israel] February 2007</ref><ref>{{cite journal |last1=Geller |first1=Tom |year=2007 |url=http://chemicalheritage.org/pubs/ch-v25n2-articles/feature_cannabinoids.html |archiveurl=http://web.archive.org/web/20080619013348/http://chemicalheritage.org/pubs/ch-v25n2-articles/feature_cannabinoids.html |archivedate=June 19, 2008 |title=Cannabinoids: A Secret History |journal=Chemical Heritage Newsmagazine |volume=25 |issue=2}}</ref> in its pure form, it is a glassy solid when cold, and becomes [[viscous]] and sticky if warmed. Synthetically prepared THC, officially referred to by its [[International Nonproprietary Name|INN]], '''dronabinol''', is available by prescription in the U.S. and Canada under the brand name '''Marinol'''. An [[aromatic]] [[terpenoid]], THC has a very low solubility in water, but good solubility in most organic [[solvent]]s, specifically [[lipid]]s and [[alcohol]]s.
  
  '''Tetrahydrocannabinol''' ({{IPAc-en|icon|ˌ|t|ɛ|t|r|ə|ˌ|h|aɪ|d|r|ɵ|k|ə|ˈ|n|æ|b|ɨ|n|ɒ|l}} {{Respell|tet-rə|HY|drə-kə|NAB|i-nol}}; '''THC'''), also known as '''delta-9-tetrahydrocannabinol''' ('''Δ<sup>9</sup>-THC'''), is the principal [[psychoactive drug|psychoactive constituent]] of the [[cannabis]] plant. First isolated in 1964,<ref name="doi10.1021/ja01062a046">{{cite journal |doi=10.1021/ja01062a046 |year=1964 |last1=Gaoni |first1=Y. |last2=Mechoulam |first2=R. |journal=Journal of the American Chemical Society |volume=86 |issue=8 |pages=1646–1647}}</ref><ref>[http://matters.ecnp.nl/number11/interview2.shtml Interview with the winner of the first ECNP Lifetime Achievement Award: Raphael Mechoulam, Israel] February 2007</ref><ref>{{cite journal |last1=Geller |first1=Tom |year=2007 |url=http://chemicalheritage.org/pubs/ch-v25n2-articles/feature_cannabinoids.html |archiveurl=http://web.archive.org/web/20080619013348/http://chemicalheritage.org/pubs/ch-v25n2-articles/feature_cannabinoids.html |archivedate=June 19, 2008 |title=Cannabinoids: A Secret History |journal=Chemical Heritage Newsmagazine |volume=25 |issue=2}}</ref> in its pure form, it is a glassy solid when cold, and becomes [[viscous]] and sticky if warmed. Synthetically prepared THC, officially referred to by its [[International Nonproprietary Name|INN]], '''dronabinol''', is available by prescription in the U.S. and Canada under the brand name '''Marinol'''. An [[aromatic]] [[terpenoid]], THC has a very low solubility in water, but good solubility in most organic [[solvent]]s, specifically [[lipid]]s and [[alcohol]]s.


  
  

  
  



  
  Like most pharmacologically-active [[secondary metabolite]]s of plants, THC in [[cannabis]] is assumed to be involved in [[self-defense]], perhaps against [[herbivore]]s<ref name=Pate1994>{{cite journal | last= Pate |first= David W. |year= 1994 |title= Chemical ecology of Cannabis |journal= Journal of the International Hemp Association |volume= 1 |issue= 29 |pages= 32–37 |url= http://www.kew.org/kbd/detailedresult.do?id=91816 }}</ref> but as of now it is still unknown. THC also possesses high [[Ultraviolet|UV-B]] (280-315&nbsp;nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.<ref name=Pate1983>{{cite journal |doi=10.1007/BF02904200 |title=Possible role of ultraviolet radiation in evolution ofCannabis chemotypes |year=1983 |last=Pate |first=David W. |journal=Economic Botany |volume=37 |issue=4 |pages=396–405}}</ref><ref name=Lydon1987a>{{cite journal |doi=10.1016/S0031-9422(00)82388-2 |title=Photochemical decomposition of cannabidiol in its resin base |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |journal=Phytochemistry |volume=26 |issue=4 |pages=1216–1217}}</ref><ref name=Lydon1987b>{{cite journal |doi=10.1111/j.1751-1097.1987.tb04757.x |title=UV-B RADIATION EFFECTS ON PHOTOSYNTHESIS, GROWTH and CANNABINOID PRODUCTION OF TWO Cannabis sativa CHEMOTYPES |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |last3=Coffman |first3=C. Benjamin |journal=Photochemistry and Photobiology |volume=46 |issue=2 |pages=201–206 |pmid=3628508}}</ref>
  
  Like most pharmacologically-active [[secondary metabolite]]s of plants, THC in [[cannabis]] is assumed to be involved in [[self-defense]], perhaps against [[herbivore]]s<ref name=Pate1994>{{cite journal | last= Pate |first= David W. |year= 1994 |title= Chemical ecology of Cannabis |journal= Journal of the International Hemp Association |volume= 1 |issue= 29 |pages= 32–37 |url= http://www.kew.org/kbd/detailedresult.do?id=91816 }}</ref> but as of now it is still unknown exactly what function THC performs in the Cannabis plant. THC possesses high [[Ultraviolet|UV-B]] (280-315&nbsp;nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.<ref name=Pate1983>{{cite journal |doi=10.1007/BF02904200 |title=Possible role of ultraviolet radiation in evolution ofCannabis chemotypes |year=1983 |last=Pate |first=David W. |journal=Economic Botany |volume=37 |issue=4 |pages=396–405}}</ref><ref name=Lydon1987a>{{cite journal |doi=10.1016/S0031-9422(00)82388-2 |title=Photochemical decomposition of cannabidiol in its resin base |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |journal=Phytochemistry |volume=26 |issue=4 |pages=1216–1217}}</ref><ref name=Lydon1987b>{{cite journal |doi=10.1111/j.1751-1097.1987.tb04757.x |title=UV-B RADIATION EFFECTS ON PHOTOSYNTHESIS, GROWTH and CANNABINOID PRODUCTION OF TWO Cannabis sativa CHEMOTYPES |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |last3=Coffman |first3=C. Benjamin |journal=Photochemistry and Photobiology |volume=46 |issue=2 |pages=201–206 |pmid=3628508}}</ref>


  
  

  
  



  
  ==Pharmacology==
  
  ==Pharmacology==
@@ Line 64: / Line 64: @@
 '''Tetrahydrocannabinol''' ({{IPAc-en|icon|ˌ|t|ɛ|t|r|ə|ˌ|h|aɪ|d|r|ɵ|k|ə|ˈ|n|æ|b|ɨ|n|ɒ|l}} {{Respell|tet-rə|HY|drə-kə|NAB|i-nol}}; '''THC'''), also known as '''delta-9-tetrahydrocannabinol''' ('''Δ<sup>9</sup>-THC'''), is the principal [[psychoactive drug|psychoactive constituent]] of the [[cannabis]] plant. First isolated in 1964,<ref name="doi10.1021/ja01062a046">{{cite journal |doi=10.1021/ja01062a046 |year=1964 |last1=Gaoni |first1=Y. |last2=Mechoulam |first2=R. |journal=Journal of the American Chemical Society |volume=86 |issue=8 |pages=1646–1647}}</ref><ref>[http://matters.ecnp.nl/number11/interview2.shtml Interview with the winner of the first ECNP Lifetime Achievement Award: Raphael Mechoulam, Israel] February 2007</ref><ref>{{cite journal |last1=Geller |first1=Tom |year=2007 |url=http://chemicalheritage.org/pubs/ch-v25n2-articles/feature_cannabinoids.html |archiveurl=http://web.archive.org/web/20080619013348/http://chemicalheritage.org/pubs/ch-v25n2-articles/feature_cannabinoids.html |archivedate=June 19, 2008 |title=Cannabinoids: A Secret History |journal=Chemical Heritage Newsmagazine |volume=25 |issue=2}}</ref> in its pure form, it is a glassy solid when cold, and becomes [[viscous]] and sticky if warmed. Synthetically prepared THC, officially referred to by its [[International Nonproprietary Name|INN]], '''dronabinol''', is available by prescription in the U.S. and Canada under the brand name '''Marinol'''. An [[aromatic]] [[terpenoid]], THC has a very low solubility in water, but good solubility in most organic [[solvent]]s, specifically [[lipid]]s and [[alcohol]]s.
-Like most pharmacologically-active [[secondary metabolite]]s of plants, THC in [[cannabis]] is assumed to be involved in [[self-defense]], perhaps against [[herbivore]]s<ref name=Pate1994>{{cite journal | last= Pate |first= David W. |year= 1994 |title= Chemical ecology of Cannabis |journal= Journal of the International Hemp Association |volume= 1 |issue= 29 |pages= 32–37 |url= http://www.kew.org/kbd/detailedresult.do?id=91816 }}</ref> but as of now it is still unknown. THC also possesses high [[Ultraviolet|UV-B]] (280-315&nbsp;nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.<ref name=Pate1983>{{cite journal |doi=10.1007/BF02904200 |title=Possible role of ultraviolet radiation in evolution ofCannabis chemotypes |year=1983 |last=Pate |first=David W. |journal=Economic Botany |volume=37 |issue=4 |pages=396–405}}</ref><ref name=Lydon1987a>{{cite journal |doi=10.1016/S0031-9422(00)82388-2 |title=Photochemical decomposition of cannabidiol in its resin base |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |journal=Phytochemistry |volume=26 |issue=4 |pages=1216–1217}}</ref><ref name=Lydon1987b>{{cite journal |doi=10.1111/j.1751-1097.1987.tb04757.x |title=UV-B RADIATION EFFECTS ON PHOTOSYNTHESIS, GROWTH and CANNABINOID PRODUCTION OF TWO Cannabis sativa CHEMOTYPES |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |last3=Coffman |first3=C. Benjamin |journal=Photochemistry and Photobiology |volume=46 |issue=2 |pages=201–206 |pmid=3628508}}</ref>
+Like most pharmacologically-active [[secondary metabolite]]s of plants, THC in [[cannabis]] is assumed to be involved in [[self-defense]], perhaps against [[herbivore]]s<ref name=Pate1994>{{cite journal | last= Pate |first= David W. |year= 1994 |title= Chemical ecology of Cannabis |journal= Journal of the International Hemp Association |volume= 1 |issue= 29 |pages= 32–37 |url= http://www.kew.org/kbd/detailedresult.do?id=91816 }}</ref> but as of now it is still unknown exactly what function THC performs in the Cannabis plant. THC possesses high [[Ultraviolet|UV-B]] (280-315&nbsp;nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.<ref name=Pate1983>{{cite journal |doi=10.1007/BF02904200 |title=Possible role of ultraviolet radiation in evolution ofCannabis chemotypes |year=1983 |last=Pate |first=David W. |journal=Economic Botany |volume=37 |issue=4 |pages=396–405}}</ref><ref name=Lydon1987a>{{cite journal |doi=10.1016/S0031-9422(00)82388-2 |title=Photochemical decomposition of cannabidiol in its resin base |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |journal=Phytochemistry |volume=26 |issue=4 |pages=1216–1217}}</ref><ref name=Lydon1987b>{{cite journal |doi=10.1111/j.1751-1097.1987.tb04757.x |title=UV-B RADIATION EFFECTS ON PHOTOSYNTHESIS, GROWTH and CANNABINOID PRODUCTION OF TWO Cannabis sativa CHEMOTYPES |year=1987 |last1=Lydon |first1=John |last2=Teramura |first2=Alan H. |last3=Coffman |first3=C. Benjamin |journal=Photochemistry and Photobiology |volume=46 |issue=2 |pages=201–206 |pmid=3628508}}</ref>
 ==Pharmacology==
-Reason:
+ANN scored at 0.916037

Reporter Information
Reporter:	Bradley (anonymous)
Date:	Tuesday, the 7th of July 2020 at 01:15:39 PM
Status:	Reviewed - Not included in dataset

Wednesday, the 21st of October 2015 at 05:18:48 PM #101622

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