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ID: 1610219
User: 217.194.165.43
Article: Dichloroacetic acid
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(Planned and ongoing clinical trials: some corrections and remove repeated sentence)
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'''Dichloroacetic acid''', often abbreviated '''DCA''', is the [[chemical compound]] with [[chemical formula|formula]] {{chem|[[Carbon|C]][[Hydrogen|H]][[Chlorine|Cl]]|2|[[Carboxylic acid|COOH]]}}. It is an [[acid]], an [[Analog (chemistry)|analogue]] of [[acetic acid]], in which two of the three hydrogen [[atoms]] of the [[methyl group]] have been replaced by [[chlorine]] atoms. The [[salts]] and [[esters]] of dichloroacetic acid are called '''dichloroacetates'''. Salts of DCA have been studied as potential drugs because they inhibit the [[enzyme]] [[pyruvate dehydrogenase kinase]].<ref>{{cite doi|10.1016.2Fj.str.2007.07.001}}</ref>
 
'''Dichloroacetic acid''', often abbreviated '''DCA''', is the [[chemical compound]] with [[chemical formula|formula]] {{chem|[[Carbon|C]][[Hydrogen|H]][[Chlorine|Cl]]|2|[[Carboxylic acid|COOH]]}}. It is an [[acid]], an [[Analog (chemistry)|analogue]] of [[acetic acid]], in which two of the three hydrogen [[atoms]] of the [[methyl group]] have been replaced by [[chlorine]] atoms. The [[salts]] and [[esters]] of dichloroacetic acid are called '''dichloroacetates'''. Salts of DCA have been studied as potential drugs because they inhibit the [[enzyme]] [[pyruvate dehydrogenase kinase]].<ref>{{cite doi|10.1016.2Fj.str.2007.07.001}}</ref>
   
Although preliminary studies have shown DCA can slow the growth of certain tumors in [[animal studies]] and ''[[in vitro]]'' studies, "Available evidence does not support the use of DCA for cancer treatment at this time."<ref>{{cite web|title=Dichloracetate (DCA)|url=http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/dichloroacetate--dca-|publisher=American Cancer Society|accessdate=1 December 2012}}</ref>
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Although preliminary studies have shown DCA can slow the growth of certain tumors in [[animal studies]] and ''[[in vitro]]'' studies, "Available evidence does not support the use of DCA for cancer treatment at this time... clinical trials (studies on human volunteers) have just been started to find out if DCA might be helpful against cancer. No human studies have been completed yet, so it is unclear how or whether it might help, or what the proper dose might be."<ref>{{cite web|title=Dichloracetate (DCA)|url=http://www.cancer.org/treatment/treatmentsandsideeffects/complementaryandalternativemedicine/pharmacologicalandbiologicaltreatment/dichloroacetate--dca-|publisher=American Cancer Society|accessdate=1 December 2012}}</ref>
   
 
== Chemistry and occurrence==
 
== Chemistry and occurrence==
Reason: ANN scored at 0.914921
Reporter Information
Reporter: Bradley (anonymous)
Date: Wednesday, the 21st of October 2015 at 06:25:42 PM
Status: Reported
Monday, the 9th of December 2013 at 07:06:12 AM #93121
Ted (anonymous)

I shortened my clarification.

Wednesday, the 21st of October 2015 at 06:25:42 PM #101705
Bradley (anonymous)

NLYTN8 http://www.FyLitCl7Pf7kjQdDUOLQOuaxTXbj5iNG.com

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