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ID: 2693349
User: Horratius
Article: Aldosterone
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'''Aldosterone''' is a [[steroid hormone]], "the main [[mineralocorticoid]] hormone",<ref>{{Cite journal|url = |title = Emerging Roles of the Mineralocorticoid Receptor in Pathology|date = January 2016|journal = [[Pharmacol. Rev.|Pharmacological Reviews]]|doi = 10.1124/pr.115.011106|pmid = |access-date = |vauthors = Jaisser F, Farman N|volume = 68|pages = 49–75}}</ref>{{Rp|50}} produced by the outer section ([[zona glomerulosa]]) of the [[adrenal cortex]] in the [[adrenal gland]].<ref>{{Cite book|title = Human anatomy & physiology|last = Marieb|first = Elaine Nicpon|publisher = Pearson|year = 2013|isbn = |location = Boston|pages = 629, Question 14|last2 = Hoehn|first2 = Katja|edition = 9th|oclc = 777127809|chapter = Chapter 16}}</ref><ref name="pmid22546854">{{cite journal |vauthors=Hu C, Rusin CG, Tan Z, Guagliardo NA, Barrett PQ |title=Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electricaloscillators. |journal=J Clin Invest. |volume=122 |issue=6 |pages=2046–2053 |date=June 2012 |pmid=22546854 |doi=10.1172/JCI61996 |url=http://www.jci.org/articles/view/61996 }}</ref> It plays a central role in the regulation of blood pressure mainly by acting on the [[distal tubule]]s and [[collecting duct]]s of the [[nephron]], increasing reabsorption of ions and water in the [[kidney]], to cause the conservation of [[sodium]], secretion of [[potassium]], increase in water retention, and increase in [[blood pressure]] and blood volume.<ref name="Marieb">Marieb Human Anatomy & Physiology 9th edition, chapter:16, page:629, question number:14</ref> When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease.<ref name="pmid22546854"/> Aldosterone has exactly the opposite function of the [[atrial natriuretic hormone]] secreted by the [[heart]].<ref name="Marieb"/>
'''Aldosterone''' is a [[steroid hormone]], "the main [[mineralocorticoid]] hormone",<ref>{{Cite journal|url = |title = Emerging Roles of the Mineralocorticoid Receptor in Pathology|date = January 2016|journal = [[Pharmacol. Rev.|Pharmacological Reviews]]|doi = 10.1124/pr.115.011106|pmid = |access-date = |vauthors = Jaisser F, Farman N|volume = 68|pages = 49–75}}</ref>{{Rp|50}} produced by the outer section ([[zona glomerulosa]]) of the [[adrenal cortex]] in the [[adrenal gland]].<ref>{{Cite book|title = Human anatomy & physiology|last = Marieb|first = Elaine Nicpon|publisher = Pearson|year = 2013|isbn = |location = Boston|pages = 629, Question 14|last2 = Hoehn|first2 = Katja|edition = 9th|oclc = 777127809|chapter = Chapter 16}}</ref><ref name="pmid22546854">{{cite journal |vauthors=Hu C, Rusin CG, Tan Z, Guagliardo NA, Barrett PQ |title=Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electricaloscillators. |journal=J Clin Invest. |volume=122 |issue=6 |pages=2046–2053 |date=June 2012 |pmid=22546854 |doi=10.1172/JCI61996 |url=http://www.jci.org/articles/view/61996 }}</ref> It plays a central role in the regulation of blood pressure mainly by acting on the [[distal tubule]]s and [[collecting duct]]s of the [[nephron]], increasing reabsorption of ions and water in the [[kidney]], to cause the conservation of [[sodium]], secretion of [[potassium]], increase in water retention, and increase in [[blood pressure]] and blood volume.<ref name="Marieb">Marieb Human Anatomy & Physiology 9th edition, chapter:16, page:629, question number:14</ref> When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease.<ref name="pmid22546854"/> Aldosterone has exactly the opposite function of the [[atrial natriuretic hormone]] secreted by the [[heart]].<ref name="Marieb"/>


Aldosterone is part of the [[renin–angiotensin system]]. Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like [[lisinopril]], which lowers blood pressure by blocking the [[angiotensin-converting enzyme]] (ACE), leading to lower aldosterone secretion. The net effect of these drugs is to reduce sodium and water retention but increase retention of potassium. Another example is [[spironolactone]], a [[potassium-sparing diuretic]] of the [[steroid]]al [[spirolactone]] group, which decreases blood pressure by releasing fluid from the body while retaining potassium.
Aldosterone is part of the [[renin–angiotensin system]]. Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like [[lisinopril]], which lowers blood pressure by blocking the [[angiotensin-converting enzyme]] (ACE), leading to lower aldosterone secretion. The net effect of these drugs is to reduce sodium and water retention but increase retention of potassium. Aldosterone antagonists decrease mortality in heart patients. Another example is [[spironolactone]], a [[potassium-sparing diuretic]] of the [[steroid]]al [[spirolactone]] group, which decreases blood pressure by releasing fluid from the body while retaining potassium.


Aldosterone was first isolated by [[Sylvia Agnes Sophia Tait|Simpson]] and [[James Francis Tait|Tait]] in 1953.<ref>{{cite journal |vauthors=Williams JS, Williams GH |title=50th anniversary of aldosterone |journal=J Clin Endocrinol Metab. |volume=88 |issue=6 |pages=2364–72 |date=June 2003 |pmid=12788829 |doi= 10.1210/jc.2003-030490|url=http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=12788829}}</ref>
Aldosterone was first isolated by [[Sylvia Agnes Sophia Tait|Simpson]] and [[James Francis Tait|Tait]] in 1953.<ref>{{cite journal |vauthors=Williams JS, Williams GH |title=50th anniversary of aldosterone |journal=J Clin Endocrinol Metab. |volume=88 |issue=6 |pages=2364–72 |date=June 2003 |pmid=12788829 |doi= 10.1210/jc.2003-030490|url=http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=12788829}}</ref>
Reason: ANN scored at 0.943305
Reporter Information
Reporter: Anonymous (anonymous)
Date: Tuesday, the 7th of July 2020 at 01:15:39 PM
Status: Reviewed - Not included in dataset