Tianeptine has been found to be an efficacious [[μ-opioid receptor]] [[agonist]] ([[Ligand (biochemistry)#Receptor/ligand binding affinity|K<sub>i</sub>]] (human) of 383 ± 183 nM and EC<sub>50</sub> (human) of 194 ± 70 nM). The same study revealed that it is also a [[δ-opioid receptor]] agonist, although with much lower potency.<ref name = gassa>{{cite journal |author1=Gassaway, MM |author2=Rives, MLL |author3=Kruegel, AC |author4=Javitch, JA |author5=Sames, D |title=The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist.|journal=Translational Psychiatry|volume=4|date=July 2014|pmid=25026323|doi=10.1038/tp.2014.30|issue=7|url=http://www.nature.com/tp/journal/v4/n7/full/tp201430a.html|pages=e411}}</ref> These actions are responsible for the [[abuse potential]] of the drug at high doses well above the normal therapeutic range. |
Tianeptine has been found to be an efficacious [[μ-opioid receptor]] [[agonist]] ([[Ligand (biochemistry)#Receptor/ligand binding affinity|K<sub>i</sub>]] (human) of 383 ± 183 nM and EC<sub>50</sub> (human) of 194 ± 70 nM). The same study revealed that it is also a [[δ-opioid receptor]] agonist, although with much lower potency.<ref name = gassa>{{cite journal |author1=Gassaway, MM |author2=Rives, MLL |author3=Kruegel, AC |author4=Javitch, JA |author5=Sames, D |title=The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist.|journal=Translational Psychiatry|volume=4|date=July 2014|pmid=25026323|doi=10.1038/tp.2014.30|issue=7|url=http://www.nature.com/tp/journal/v4/n7/full/tp201430a.html|pages=e411}}</ref> These actions are responsible for the [[abuse potential]] of the drug at high doses well above the normal therapeutic range. |
Added table showing different sites of binding for Tianeptine - NOT, I repeat, NOT an attempt at vandalism.