| Title | Authors (identified) | Published In | Identifier(s) | Topic | Published Date | Match? |
|---|
| A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin | [1]Anupriya S Kulkarni, [2]Masad J Damha, [3]Raymond F. Schinazi, [4]Hongmei Mo, [5]Brian Doehle, [6]Selena M Sagan, [7]Matthias Götte [Full author list] | Antimicrobial Agents and Chemotherapy [missing] | DOI: 10.1128/AAC.02436-15 [ORCID]
PubMed: 26824949 [ORCID]
| ribavirin [missing]; complex network [missing]; Hepatitis C virus [missing]; sofosbuvir [missing] | 2016-01-11 | Matthias Götte (Q89230735; 6 items)
|
| Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates | [1]Jubi John, [2]Youngju Kim, [3]Nicholas Bennett, [4]Kalyan Das, [5]Sandra Liekens, [6]Lieve Naesens, [7]Eddy Arnold, [8]Anita R Maguire, [9]Matthias Götte, [10]Wim Dehaen, [11]Jan Balzarini [Full author list] | Journal of Medicinal Chemistry [missing] | DOI: 10.1021/ACS.JMEDCHEM.5B01180 [ORCID]
PubMed: 26450273 [ORCID]
| | 2015-10-09 | |
| Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics | [1]Jan Balzarini, [2]Kalyan Das, [3]Jean A Bernatchez, [4]Sergio E Martinez, [5]Marianne Ngure, [6]Sarah Keane, [7]Alan Ford, [8]Nuala Maguire, [9]Niki Mullins, [10]Jubi John, [11]Youngju Kim, [12]Wim Dehaen, [13]Johan Vande Voorde, [14]Sandra Liekens, [15]Lieve Naesens, [16]Matthias Götte, [17]Anita R Maguire, [18]Eddy Arnold [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [missing] | DOI: 10.1073/PNAS.1420233112 [ORCID]
PubMed: 25733891 [ORCID]
| | 2015-03-02 | |
| Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation | [1]Greg L Beilhartz, [2]Marianne Ngure, [3]Brian A Johns, [4]Felix DeAnda, [5]Peter Gerondelis, [6]Matthias Götte [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M114.569707 [ORCID]
PubMed: 24719329 [ORCID]
| | 2014-04-09 | |
| Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNA | [1]Pierre Karam, [2]Megan H Powdrill, [3]Hsiao-Wei Liu, [4]Colins Vasquez, [5]Wayne Mah, [6]Jean A Bernatchez, [7]Matthias Götte, [8]Gonzalo Cosa [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M113.529743 [ORCID]
PubMed: 24692556 [ORCID]
| Hepatitis C virus [missing] | 2014-04-01 | Matthias Götte (Q89230735; 6 items)
|
| Binding kinetics and affinities of heterodimeric versus homodimeric HIV-1 reverse transcriptase on DNA-DNA substrates at the single-molecule level | [1]Ryan A Marko, [2]Hsiao-Wei Liu, [3]Christopher J Ablenas, [4]Maryam Ehteshami, [5]Matthias Götte, [6]Gonzalo Cosa [Full author list] | Journal of Physical Chemistry B [missing] | DOI: 10.1021/JP308674G [ORCID]
PubMed: 23305243 [ORCID]
| | 2013-02-01 | Matthias Götte (Q89230735; 6 items)
|
| Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs | [1]Nicholas Bennett, [2]Matthias Götte [Full author list] | Viruses [missing] | DOI: 10.3390/V5010054 [ORCID]
PubMed: 23299784 [ORCID]
| virus [missing]; enzyme [missing]; bacteriophage [missing]; viral protein [missing]; Herpesviridae infectious disease [missing] | 2013-01-08 | |
| Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance | [1]Megan H Powdrill, [2]Egor P Tchesnokov, [3]Robert A Kozak, [4]Rodney S Russell, [5]Ross Martin, [6]Evguenia S Svarovskaia, [7]Hongmei Mo, [8]Roger Kouyos, [9]Matthias Götte [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [missing] | DOI: 10.1073/PNAS.1105797108 [ORCID]
PubMed: 22135458 [ORCID]
| hepatitis C [missing]; Hepatitis C virus [missing]; bias [missing] | 2011-12-01 | Matthias Götte (Q89230735; 6 items)
|
| Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates | [1]Junxing Shi, [2]Longhu Zhou, [3]Hongwang Zhang, [4]Tamara R McBrayer, [5]Mervi A Detorio, [6]Melissa Johns, [7]Leda Bassit, [8]Megan H Powdrill, [9]Tony Whitaker, [10]Steven J Coats, [11]Matthias Götte, [12]Raymond F. Schinazi [Full author list] | Bioorganic & Medicinal Chemistry Letters [missing] | DOI: 10.1016/J.BMCL.2011.09.089 [ORCID]
PubMed: 22014549 [ORCID]
| | 2011-09-29 | Matthias Götte (Q89230735; 6 items)
|
| Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase | [1]Karl E Zahn, [2]Egor P Tchesnokov, [3]Matthias Götte, [4]Sylvie Doublié [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M111.248864 [ORCID]
PubMed: 21566148 [ORCID]
| cell biology [missing]; foscarnet [missing]; viral genome replication [missing] | 2011-07-15 | |
| Impact of primer-induced conformational dynamics of HIV-1 reverse transcriptase on polymerase translocation and inhibition | [1]Anick Auger, [2]Greg L Beilhartz, [3]Siqi Zhu, [4]Elizabeth Cauchon, [5]Jean-Pierre Falgueyret, [6]Jay A Grobler, [7]Maryam Ehteshami, [8]Matthias Götte, [9]Roman A Melnyk [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M111.268235 [ORCID]
PubMed: 21737446 [ORCID]
| | 2011-07-07 | |
| Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase | [1]Jan Martin Berke, [2]Leen Vijgen, [3]Sophie Lachau-Durand, [4]Megan H Powdrill, [5]Svea Rawe, [6]Elena Sjuvarsson, [7]Staffan Eriksson, [8]Matthias Götte, [9]Els Fransen, [10]Pascale Dehertogh, [11]Christel Van den Eynde, [12]Laurent Leclercq, [13]Tim H M Jonckers, [14]Pierre Raboisson, [15]Magnus Nilsson, [16]Bertil Samuelsson, [17]Åsa Rosenquist, [18]Gregory C Fanning, [19]Tse-I Lin [Full author list] | Antimicrobial Agents and Chemotherapy [missing] | DOI: 10.1128/AAC.00214-11 [ORCID]
PubMed: 21576430 [ORCID]
| Hepatitis C virus [missing] | 2011-05-16 | Matthias Götte (Q89230735; 6 items)
|
| Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans | [1]Noortje M van Maarseveen, [2]Annemarie Mj Wensing, [3]Dorien de Jong, [4]Greg L Beilhartz, [5]Aleksandr Obikhod, [6]Sijia Tao, [7]Marieke Pingen, [8]Joop E Arends, [9]Andy Im Hoepelman, [10]Raymond F. Schinazi, [11]Matthias Götte, [12]Monique Nijhuis [Full author list] | Antiviral Therapy [missing] | DOI: 10.3851/IMP1912 [ORCID]
PubMed: 22024528 [ORCID]
| | 2011-01-01 | Matthias Götte (Q89230735; 6 items)
|
| Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. | [1]Megan H Powdrill, [2]Jean A Bernatchez, [3]Matthias Götte [Full author list] | Viruses [missing] | DOI: 10.3390/V2102169 [ORCID]
PubMed: 21994615 [ORCID]
| hepatitis C [missing]; Hepatitis C virus [missing] | 2010-09-28 | Matthias Götte (Q89230735; 6 items)
|
| N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation | [1]Mia J Biondi, [2]Greg L Beilhartz, [3]Suzanne McCormick, [4]Matthias Götte [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M110.105775 [ORCID]
PubMed: 20530477 [ORCID]
| bias [missing] | 2010-06-08 | |
| Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines | [1]Megan H Powdrill, [2]Jerome Deval, [3]Frank Narjes, [4]Raffaele De Francesco, [5]Matthias Götte [Full author list] | Antimicrobial Agents and Chemotherapy [missing] | DOI: 10.1128/AAC.01216-09 [ORCID]
PubMed: 20028820 [ORCID]
| hepatitis C [missing]; Hepatitis C virus [missing] | 2010-03-01 | Matthias Götte (Q89230735; 6 items)
|
| Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme | [1]Egor P Tchesnokov, [2]Aleksandr Obikhod, [3]Raymond F. Schinazi, [4]Matthias Götte [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M109.012500 [ORCID]
PubMed: 19622750 [ORCID]
| Cytomegalovirus [missing] | 2009-07-21 | Matthias Götte (Q89230735; 6 items)
|
| Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase | [1]Egor P Tchesnokov, [2]Aleksandr Obikhod, [3]Ivana Massud, [4]Andrea Lisco, [5]Christophe Vanpouille, [6]Beda Břicháček, [7]Jan Balzarini, [8]Christopher McGuigan, [9]Marco Derudas, [10]Leonid Margolis, [11]Raymond F. Schinazi, [12]Matthias Götte [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M109.024026 [ORCID]
PubMed: 19509419 [ORCID]
| aciclovir [missing] | 2009-06-09 | Matthias Götte (Q89230735; 6 items)
|
| Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues | [1]Andrea Lisco, [2]Christophe Vanpouille, [3]Egor P Tchesnokov, [4]Jean-Charles Grivel, [5]Angélique Biancotto, [6]Beda Břicháček, [7]Julie Elliott, [8]Emilie Fromentin, [9]Robin Shattock, [10]Peter Anton, [11]Robert J Gorelick, [12]Jan Balzarini, [13]Christopher McGuigan, [14]Marco Derudas, [15]Matthias Götte, [16]Raymond F. Schinazi, [17]Leonid Margolis [Full author list] | Cell Host & Microbe [missing] | DOI: 10.1016/J.CHOM.2008.07.008 [ORCID]
PubMed: 18779052 [ORCID]
| aciclovir [missing] | 2008-09-01 | Matthias Götte (Q89230735; 6 items)
|
| Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase | [1]Jérôme Deval, [2]Megan H Powdrill, [3]Claudia M D'Abramo, [4]Luciano Cellai, [5]Matthias Götte [Full author list] | Antimicrobial Agents and Chemotherapy [missing] | DOI: 10.1128/AAC.00186-07 [ORCID]
PubMed: 17502402 [ORCID]
| Hepatitis C virus [missing] | 2007-08-01 | Matthias Götte (Q89230735; 6 items)
|
| The pyrophosphate analogue foscarnet traps the pre-translocational state of HIV-1 reverse transcriptase in a Brownian ratchet model of polymerase translocation | [1]Bruno Marchand, [2]Egor P Tchesnokov, [3]Matthias Götte [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M607710200 [ORCID]
PubMed: 17145704 [ORCID]
| | 2006-11-30 | |
| Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action | [1]Dirk Jochmans, [2]Jérôme Deval, [3]Bart Kesteleyn, [4]Herwig Van Marck, [5]Eva Bettens, [6]Inky De Baere, [7]Pascale Dehertogh, [8]Tania Ivens, [9]Marcia Van Ginderen, [10]Bertrand Van Schoubroeck, [11]Maryam Ehteshami, [12]Piet Wigerinck, [13]Matthias Götte, [14]Kurt Hertogs [Full author list] | Journal of Virology [missing] | DOI: 10.1128/JVI.00889-06 [ORCID]
PubMed: 17020946 [ORCID]
| | 2006-10-04 | |