| Title | Authors (identified) | Published In | Identifier(s) | Topic | Published Date |
|---|
| Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer | [1]Dhanir Tailor, [2]Catherine C Going, [3]Angel Resendez, [4]Vineet Kumar, [5]Dhanya K Nambiar, [6]Yang Li, [7]Arpit Dheeraj, [8]Edward Lewis LaGory, [9]Ali Ghoochani, [10]Alisha M Birk, [11]Tanya Stoyanova, [12]Jiangbin Ye, [13]Amato J. Giaccia, [14]Quynh-Thu Le, [15]Rana P Singh, [16]George W Sledge, [17]Sharon J Pitteri, [18]Sanjay V Malhotra [Full author list] | British Journal of Cancer [curation] | DOI: 10.1038/S41416-020-01137-4
PubMed: 33139797 | triple-negative breast cancer [curation] | 2020-11-03 |
| Mitochondrial copper depletion suppresses triple-negative breast cancer in mice | [1]Liyang Cui, [2]Arvin Gouw, [3]Edward L LaGory, [4]Shenghao Guo, [5]Nabeel Attarwala, [6]Yao Tang, [7]Ji Qi, [8]Yun-Sheng Chen, [9]Zhou Gao, [10]Kerriann M. Casey, ..., [17]Qihua Zhu, [18]Zhiyuan Wang, [19]Amato J. Giaccia, [20]Sanjiv Sam Gambhir, [21]Weiping Zhu, ... [Full author list] | Nature Biotechnology [curation] | DOI: 10.1038/S41587-020-0707-9
PubMed: 33077961 | triple-negative breast cancer [curation] | 2020-10-19 |
| Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis | [1]Monica M Olcina, [2]Ryan K Kim, [3]Nikolas G Balanis, [4]Caiyun Grace Li, [5]Rie von Eyben, [6]Thomas G Graeber, [7]Daniel Ricklin, [8]Manuel Stucki, [9]Amato J. Giaccia [Full author list] | iScience [curation] | DOI: 10.1016/J.ISCI.2020.101594
PubMed: 33205012 | NF-κB [curation] | 2020-09-21 |
| Validated limited gene predictor for cervical cancer lymph node metastases | [1]Joshua D Bloomstein, [2]Rie von Eyben, [3]Andy Chan, [4]Erinn B Rankin, [5]Daniel R Fregoso, [6]Jing Wang-Chiang, [7]Lisa Lee, [8]Liang-Xi Xie, [9]Shannon MacLaughlan David, [10]Henning Stehr, [11]Mohammad S Esfahani, [12]Amato J. Giaccia, [13]Elizabeth A Kidd [Full author list] | Oncotarget [curation] | DOI: 10.18632/ONCOTARGET.27632
PubMed: 32595829 | | 2020-06-16 |
| Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis | [1]Janine T Erler, [2]Kevin L Bennewith, [3]Monica Nicolau, [4]Nadja Dornhöfer, [5]Christina Kong, [6]Quynh-Thu Le, [7]Jen-Tsan Ashley Chi, [8]Stefanie S Jeffrey, [9]Amato J. Giaccia [Full author list] | Nature [curation] | DOI: 10.1038/S41586-020-2112-4
PubMed: 32188947 | | 2020-03-01 |
| Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma | [1]Soichiro Nishioka, [2]Ping-Hsiu Wu, [3]Toshiaki Yakabe, [4]Amato J. Giaccia, [5]Quynh-Thu Le, [6]Hidefumi Aoyama, [7]Shinichi Shimizu, [8]Hiroki Shirato, [9]Yasuhito Onodera, [10]Jin-Min Nam [Full author list] | Neuro-Oncology Advances [curation] | DOI: 10.1093/NOAJNL/VDAA091
PubMed: 33409495 | glioblastoma [curation] | 2020-01-01 |
| Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance | [1]Dhanya K Nambiar, [2]Todd Aguilera, [3]Hongbin Cao, [4]Shirley Kwok, [5]Christina Kong, [6]Joshua Bloomstein, [7]Zemin Wang, [8]Vangipuram S Rangan, [9]Dadi Jiang, [10]Rie von Eyben, [11]Rachel Liang, [12]Sonya Agarwal, [13]A Dimitrios Colevas, [14]Alan Korman, [15]Clint T Allen, [16]Ravindra Uppaluri, [17]Albert C Koong, [18]Amato J. Giaccia, [19]Quynh Thu Le [Full author list] | Journal of Clinical Investigation [curation] | DOI: 10.1172/JCI129025
PubMed: 31710313 | immunotherapy [curation] | 2019-12-01 |
| An Activatable NIR Fluorescent Rosol for Selectively Imaging Nitroreductase Activity | [1]Jessica L Klockow, [2]Kenneth S Hettie, [3]Edward L LaGory, [4]Eui Jung Moon, [5]Amato J. Giaccia, [6]Edward E Graves, [7]Frederick T Chin [Full author list] | Sensors and Actuators B [curation] | DOI: 10.1016/J.SNB.2019.127446
PubMed: 32265579 | | 2019-11-30 |
| Irradiation or temozolomide chemotherapy enhances anti-CD47 treatment of glioblastoma | [1]Sharareh Gholamin, [2]Osama A Youssef, [3]Marjan Rafat, [4]Rogelio Esparza, [5]Suzana Kahn, [6]Maryam Shahin, [7]Amato J. Giaccia, [8]Edward E Graves, [9]Irving Weissman, [10]Siddhartha Mitra, [11]Samuel H Cheshier [Full author list] | Innate Immunity [curation] | DOI: 10.1177/1753425919876690
PubMed: 31547758 | glioblastoma [curation]; temozolomide [curation] | 2019-09-23 |
| HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors | [1]Matthew J VandeKopple, [2]Jinghai Wu, [3]Erich N Auer, [4]Amato J. Giaccia, [5]Nicholas C Denko, [6]Ioanna Papandreou [Full author list] | Molecular Cancer Research [curation] | DOI: 10.1158/1541-7786.MCR-18-1343
PubMed: 31308147 | | 2019-07-15 |
| Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate | [1]Qing Yao, [2]Mohd Parvez Khan, [3]Christophe Merceron, [4]Edward L LaGory, [5]Zachary Tata, [6]Laura Mangiavini, [7]Jiarui Hu, [8]Krishna Vemulapalli, [9]Navdeep S Chandel, [10]Amato J. Giaccia, [11]Ernestina Schipani [Full author list] | Developmental Cell [curation] | DOI: 10.1016/J.DEVCEL.2019.04.029
PubMed: 31105007 | | 2019-05-16 |
| Wounds Inhibit Tumor Growth In Vivo | [1]Michael S Hu, [2]Zeshaan N Maan, [3]Tripp Leavitt, [4]Wan Xing Hong, [5]Robert C Rennert, [6]Clement D Marshall, [7]Mimi R Borrelli, [8]Ted N Zhu, [9]Mikaela Esquivel, [10]Andrew Zimmermann, [11]Adrian McArdle, [12]Michael T Chung, [13]Deshka S Foster, [14]Ruth Ellen Jones, [15]Geoffrey C. Gurtner, [16]Amato J. Giaccia, [17]H Peter Lorenz, [18]Irving Weissman, [19]Michael T Longaker [Full author list] | Annals of Surgery [curation] | DOI: 10.1097/SLA.0000000000003255
PubMed: 30829705 | | 2019-02-27 |
| Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual | [1]Christophe Merceron, [2]Kavitha Ranganathan, [3]Elizabeth Wang, [4]Zachary Tata, [5]Shreya Makkapati, [6]Mohd Parvez Khan, [7]Laura Mangiavini, [8]Angela Qing Yao, [9]Laura Castellini, [10]Benjamin Levi, [11]Amato J. Giaccia, [12]Ernestina Schipani [Full author list] | Bone research [curation] | DOI: 10.1038/S41413-019-0045-Z
PubMed: 30792937 | hypoxia [curation] | 2019-02-21 |
| Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop | [1]Heather M McGee, [2]Dadi Jiang, [3]David R Soto-Pantoja, [4]Avinoam Nevler, [5]Amato J. Giaccia, [6]Wendy A Woodward [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-18-3781
PubMed: 30723144 | radiation oncology [curation] | 2019-02-05 |
| The tumour microenvironment links complement system dysregulation and hypoxic signalling | [1]Monica M Olcina, [2]Ryan K Kim, [3]Stavros Melemenidis, [4]Edward E Graves, [5]Amato J. Giaccia [Full author list] | British Journal of Radiology [curation] | DOI: 10.1259/BJR.20180069
PubMed: 29544344 | hypoxia [curation]; neoplasm [curation]; tumor microenvironment [curation]; complement system proteins [curation] | 2019-01-01 |
| Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer | [1]Monica M Olcina, [2]Nikolas G Balanis, [3]Ryan K Kim, [4]B Arman Aksoy, [5]Julia Kodysh, [6]Michael J Thompson, [7]Jeff Hammerbacher, [8]Thomas G Graeber, [9]Amato J. Giaccia [Full author list] | Cell Reports [curation] | DOI: 10.1016/J.CELREP.2018.11.093
PubMed: 30590044 | | 2018-12-01 |
| Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism | [1]Martin Benej, [2]Xiangqian Hong, [3]Sandip Vibhute, [4]Sabina Scott, [5]Jinghai Wu, [6]Edward Graves, [7]Quynh-Thu Le, [8]Albert C Koong, [9]Amato J. Giaccia, [10]Bing Yu, [11]Ching-Shih Chen, [12]Ioanna Papandreou, [13]Nicholas C Denko [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [curation] | DOI: 10.1073/PNAS.1808945115
PubMed: 30201710 | | 2018-09-10 |
| Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients | [1]Marjan Rafat, [2]Todd Aguilera, [3]Marta Vilalta, [4]Laura L Bronsart, [5]Luis A Soto, [6]Rie von Eyben, [7]Meghana A Golla, [8]Yasaman Ahrari, [9]Stavros Melemenidis, [10]Anosheh Afghahi, [11]Melissa J Jenkins, [12]Allison W Kurian, [13]Kathleen C Horst, [14]Amato J. Giaccia, [15]Edward E Graves [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-17-3623
PubMed: 29880480 | | 2018-06-07 |
| Selection of external beam radiotherapy approaches for precise and accurate cancer treatment. | [1]Hiroki Shirato, [2]Quynh-Thu Le, [3]Keiji Kobashi, [4]Anussara Prayongrat, [5]Seishin Takao, [6]Shinichi Shimizu, [7]Amato J. Giaccia, [8]Lei Xing, [9]Kikuo Umegaki [Full author list] | Journal of Radiation Research [curation] | DOI: 10.1093/JRR/RRX092
PubMed: 29373709 | | 2018-03-01 |
| A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation | [1]Zhifen Yang, [2]Jing Zhang, [3]Dadi Jiang, [4]Purvesh Khatri, [5]David E Solow-Cordero, [6]Diego A S Toesca, [7]Constantinos Koumenis, [8]Nicholas C Denko, [9]Amato J. Giaccia, [10]Quynh-Thu Le, [11]Albert C Koong [Full author list] | Molecular Cancer Research [curation] | DOI: 10.1158/1541-7786.MCR-17-0307
PubMed: 29440447 | | 2018-02-09 |
| PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. | [1]Sae Hee Ko, [2]Allison C Nauta, [3]Shane D Morrison, [4]Michael S Hu, [5]Andrew S Zimmermann, [6]Michael T Chung, [7]Jason P Glotzbach, [8]Victor W Wong, [9]Graham G Walmsley, [10]H Peter Lorenz, [11]Denise A Chan, [12]Geoffrey C. Gurtner, [13]Amato J. Giaccia, [14]Michael T Longaker [Full author list] | Plastic and Reconstructive Surgery [curation] | DOI: 10.1097/PRS.0000000000003959
PubMed: 29280872 | wound healing [curation] | 2018-01-01 |
| Long-range hypoxia signaling in NAFLD. | [1]Edward L LaGory, [2]Amato J. Giaccia [Full author list] | Nature Medicine [curation] | DOI: 10.1038/NM.4436
PubMed: 29117167 | | 2017-11-01 |
| BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer | [1]Shin-Heng Chiou, [2]Viviana Risca, [3]Gordon X Wang, [4]Dian Yang, [5]Barbara M Grüner, [6]Arwa S Kathiria, [7]Rosanna K. Ma, [8]Dedeepya Vaka, [9]Pauline Chu, [10]Margaret Kozak, [11]Laura Castellini, [12]Edward E Graves, [13]Grace E Kim, [14]Philippe Mourrain, [15]Albert C. Koong, [16]Amato J. Giaccia, [17]Monte M Winslow [Full author list] | Cancer Discovery [curation] | DOI: 10.1158/2159-8290.CD-17-0250
PubMed: 28790031 | heterogeneity [curation] | 2017-08-08 |
| Stress-responsive HILPDA is necessary for thermoregulation during fasting. | [1]Matthew J VandeKopple, [2]Jinghai Wu, [3]Lisa A Baer, [4]Naresh C Bal, [5]Santosh K Maurya, [6]Anuradha Kalyanasundaram, [7]Muthu Periasamy, [8]Kristin I Stanford, [9]Amato J. Giaccia, [10]Nicholas C Denko, [11]Ioanna Papandreou [Full author list] | Journal of Endocrinology [curation] | DOI: 10.1530/JOE-17-0289
PubMed: 28739822 | thermoregulation [curation] | 2017-07-24 |
| Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells | [1]Ping-Hsiu Wu, [2]Yasuhito Onodera, [3]Yuki Ichikawa, [4]Erinn B Rankin, [5]Amato J. Giaccia, [6]Yuko Watanabe, [7]Wei Qian, [8]Takayuki Hashimoto, [9]Hiroki Shirato, [10]Jin-Min Nam [Full author list] | International Journal of Nanomedicine [curation] | DOI: 10.2147/IJN.S137833
PubMed: 28860745 | nanoparticle [curation] | 2017-07-14 |
| Hypoxia and Bone Metastatic Disease | [1]Rachelle W Johnson, [2]Miranda E Sowder, [3]Amato J. Giaccia [Full author list] | Current osteoporosis reports [curation] | DOI: 10.1007/S11914-017-0378-8
PubMed: 28597139 | | 2017-06-08 |
| Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location | [1]Marta Vilalta, [2]Nicholas P Hughes, [3]Rie Von Eyben, [4]Amato J. Giaccia, [5]Edward E Graves [Full author list] | Molecular Imaging and Biology [curation] | DOI: 10.1007/S11307-016-1010-5
PubMed: 27709411 | | 2017-04-01 |
| Pre-metastatic niches: organ-specific homes for metastases | [1]Héctor Peinado, [2]Haiying Zhang, [3]Irina R Matei, [4]Bruno Costa-Silva, [5]Ayuko Hoshino, [6]Goncalo Rodrigues, [7]Beth Psaila, [8]Rosandra N Kaplan, [9]Jacqueline F Bromberg, [10]Yibin Kang, [11]Mina Bissell, [12]Thomas R Cox, [13]Amato J. Giaccia, [14]Janine T. Erler, [15]Sachie Hiratsuka, [16]Cyrus M Ghajar, [17]David Lyden [Full author list] | Nature Reviews Cancer [curation] | DOI: 10.1038/NRC.2017.6
PubMed: 28303905 | | 2017-03-17 |
| Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase | [1]Todd A Aguilera, [2]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-17-0189
PubMed: 28289089 | evasion of host immune response [curation] | 2017-03-13 |
| KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage | [1]Laura Castellini, [2]Eui Jung Moon, [3]Olga V Razorenova, [4]Adam J. Krieg, [5]Rie von Eyben, [6]Amato J. Giaccia [Full author list] | Nucleic Acids Research [curation] | DOI: 10.1093/NAR/GKW1281
PubMed: 28073943 | DNA damage [curation] | 2017-01-09 |
| Reprogramming the immunological microenvironment through radiation and targeting Axl. | [1]Todd Aguilera, [2]Marjan Rafat, [3]Laura Castellini, [4]Hussein Shehade, [5]Mihalis S Kariolis, [6]Angela Bik-Yu Hui, [7]Henning Stehr, [8]Rie von Eyben, [9]Dadi Jiang, [10]Lesley G Ellies, [11]Albert C. Koong, [12]Maximilian Diehn, [13]Erinn B. Rankin, [14]Edward E Graves, [15]Amato J. Giaccia [Full author list] | Nature Communications [curation] | DOI: 10.1038/NCOMMS13898
PubMed: 28008921 | immunology [curation] | 2016-12-23 |
| Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies | [1]Mihalis S Kariolis, [2]Yu Rebecca Miao, [3]Anh Diep, [4]Shannon E Nash, [5]Monica M Olcina, [6]Dadi Jiang, [7]Douglas S Jones, [8]Shiven Kapur, [9]Irimpan I Mathews, [10]Albert C. Koong, [11]Erinn B. Rankin, [12]Jennifer R Cochran, [13]Amato J. Giaccia [Full author list] | Journal of Clinical Investigation [curation] | DOI: 10.1172/JCI85610
PubMed: 27893463 | | 2016-11-28 |
| 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016. | [1]Casey R Ager, [2]Matthew Reilley, [3]Courtney Nicholas, [4]Todd Bartkowiak, [5]Ashvin R Jaiswal, [6]Michael A. Curran, [7]Tina C. Albershardt, [8]Anshika Bajaj, [9]Jacob F. Archer, [10]Rebecca S. Reeves, ..., [1417]Erinn Rankin, [1418]Albert C. Koong, [1419]Amato J. Giaccia, [1420]Reham Ajina, [1421]Shangzi Wang, ... [Full author list] | Journal for Immunotherapy of Cancer [curation] | DOI: 10.1186/S40425-016-0173-6
| immunotherapy [curation] | 2016-11-16 |
| The Receptor Tyrosine Kinase AXL in Cancer Progression | [1]Erinn B. Rankin, [2]Amato J. Giaccia [Full author list] | Cancers [curation] | DOI: 10.3390/CANCERS8110103
PubMed: 27834845 | | 2016-11-09 |
| Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow | [1]Rachelle W Johnson, [2]Elizabeth C Finger, [3]Monica M Olcina, [4]Marta Vilalta, [5]Todd Aguilera, [6]Yu Miao, [7]Alyssa R Merkel, [8]Joshua R Johnson, [9]Julie A Sterling, [10]Joy Y Wu, [11]Amato J. Giaccia [Full author list] | Nature Cell Biology [curation] | DOI: 10.1038/NCB3433
PubMed: 27784904 | | 2016-10-01 |
| Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow | [1]Rachelle W Johnson, [2]Elizabeth C Finger, [3]Monica M Olcina, [4]Marta Vilalta, [5]Todd Aguilera, [6]Yu Miao, [7]Alyssa R Merkel, [8]Joshua R Johnson, [9]Julie A Sterling, [10]Joy Y Wu, [11]Amato J. Giaccia [Full author list] | Nature Cell Biology [curation] | DOI: 10.1038/NCB3408
PubMed: 27642788 | phenotype [curation]; breast cancer [curation]; bone marrow [curation] | 2016-09-19 |
| Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response | [1]Dadi Jiang, [2]Connor Lynch, [3]Bruno C Medeiros, [4]Michaela Liedtke, [5]Rakesh Bam, [6]Arvin B Tam, [7]Zhifen Yang, [8]Muthuraman Alagappan, [9]Parveen Abidi, [10]Quynh-Thu Le, [11]Amato J. Giaccia, [12]Nicholas C Denko, [13]Maho Niwa, [14]Albert C. Koong [Full author list] | Scientific Reports [curation] | DOI: 10.1038/SREP33353
PubMed: 27634301 | doxorubicin [curation] | 2016-09-16 |
| Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis | [1]Monica M Olcina, [2]Amato J. Giaccia [Full author list] | Journal of Clinical Investigation [curation] | DOI: 10.1172/JCI84432
PubMed: 27548524 | | 2016-08-22 |
| Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma | [1]Dadi Jiang, [2]Arvin B Tam, [3]Muthuraman Alagappan, [4]Michael P. Hay, [5]Aparna Gupta, [6]Margaret M Kozak, [7]David E Solow-Cordero, [8]Pek Y Lum, [9]Nicholas C Denko, [10]Amato J. Giaccia, [11]Quynh-Thu Le, [12]Maho Niwa, [13]Albert C. Koong [Full author list] | Molecular Cancer Therapeutics [curation] | DOI: 10.1158/1535-7163.MCT-15-1023
PubMed: 27307600 | | 2016-06-15 |
| Hypoxia: Signaling the Metastatic Cascade | [1]Erinn B. Rankin, [2]Jin-Min Nam, [3]Amato J. Giaccia [Full author list] | Trends in cancer [curation] | DOI: 10.1016/J.TRECAN.2016.05.006
PubMed: 28741527 | hypoxia [curation] | 2016-06-02 |
| Hypoxic control of metastasis | [1]Erinn B. Rankin, [2]Amato J. Giaccia [Full author list] | Science [curation] | DOI: 10.1126/SCIENCE.AAF4405
PubMed: 27124451 | hypoxia [curation] | 2016-04-08 |
| Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1 | [1]Katarzyna Leszczyńska, [2]Eva-Leonne Göttgens, [3]Deborah Biasoli, [4]Monica M Olcina, [5]Jonathan Ient, [6]Selvakumar Anbalagan, [7]Stephan Bernhardt, [8]Amato J. Giaccia, [9]Ester M Hammond [Full author list] | Scientific Reports [curation] | DOI: 10.1038/SREP21698
PubMed: 26875667 | hypoxia [curation] | 2016-02-15 |
| Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells | [1]Ramon Sun, [2]Albert C. Koong, [3]Amato J. Giaccia, [4]Nicholas C Denko [Full author list] | Advances in Experimental Medicine and Biology [curation] | DOI: 10.1007/978-3-319-26666-4_7
PubMed: 27325264 | | 2016-01-01 |
| Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions | [1]Monica M Olcina, [2]Amato J. Giaccia, [3]Ester M Hammond [Full author list] | Advances in Experimental Medicine and Biology [curation] | DOI: 10.1007/978-3-319-26666-4_3
PubMed: 27325260 | | 2016-01-01 |
| Tumor immunologic heterogeneity influences response to radiation and combination immunotherapy. | [1]Todd Aguilera, [2]Marjan Rafat, [3]Mihalis Kariolis, [4]Rie von Eyben, [5]Edward Graves, [6]Amato J. Giaccia [Full author list] | Journal for Immunotherapy of Cancer [curation] | DOI: 10.1186/2051-1426-3-S2-P345
| immunotherapy [curation] | 2015-11-04 |
| Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors | [1]Laura Mangiavini, [2]Christophe Merceron, [3]Elisa Araldi, [4]Richa Khatri, [5]Rita Gerard-O'Riley, [6]Tremika L Wilson, [7]George E. Sandusky, [8]Jerome Abadie, [9]Karen M Lyons, [10]Amato J. Giaccia, [11]Ernestina Schipani [Full author list] | The American Journal of Pathology [curation] | DOI: 10.1016/J.AJPATH.2015.07.008
PubMed: 26348575 | | 2015-09-05 |
| Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy | [1]Erqi L Pollom, [2]Lei Deng, [3]Reetesh K Pai, [4]J Martin Brown, [5]Amato J. Giaccia, [6]Billy W Loo, [7]David B. Shultz, [8]Quynh Thu Le, [9]Albert C. Koong, [10]Daniel T Chang [Full author list] | International Journal of Radiation Oncology Biology Physics [curation] | DOI: 10.1016/J.IJROBP.2015.02.016
PubMed: 26068491 | radiation therapy [curation]; angiogenesis inhibitor [curation] | 2015-07-01 |
| Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma | [1]Edward L LaGory, [2]Colleen Wu, [3]Cullen M Taniguchi, [4]Chien-Kuang Cornelia Ding, [5]Jen-Tsan A Chi, [6]Rie von Eyben, [7]David A Scott, [8]Adam D Richardson, [9]Amato J. Giaccia [Full author list] | Cell Reports [curation] | DOI: 10.1016/J.CELREP.2015.06.006
PubMed: 26119730 | renal cell carcinoma [curation] | 2015-06-25 |
| Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin | [1]Colleen Wu, [2]Erinn B Rankin, [3]Laura Castellini, [4]Javier F Alcudia, [5]Edward L LaGory, [6]Rebecca Andersen, [7]Steven D Rhodes, [8]Tremika L S Wilson, [9]Khalid S Mohammad, [10]Alesha B Castillo, [11]Theresa A Guise, [12]Ernestina Schipani, [13]Amato J. Giaccia [Full author list] | Genes & Development [curation] | PubMed: 26063577 | Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin [curation]; oxygen sensing [curation] | 2015-06-01 |
| Emerging Treatment Paradigms in Radiation Oncology | [1]Quynh-Thu Le, [2]Hiroki Shirato, [3]Amato J. Giaccia, [4]Albert C. Koong [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-14-1191
PubMed: 25991820 | radiation oncology [curation] | 2015-05-19 |
| Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin | [1]Colleen Wu, [2]Erinn B. Rankin, [3]Laura Castellini, [4]Javier F Alcudia, [5]Edward L LaGory, [6]Rebecca Andersen, [7]Steven D Rhodes, [8]Tremika L S Wilson, [9]Khalid S Mohammad, [10]Alesha B Castillo, [11]Theresa A Guise, [12]Ernestina Schipani, [13]Amato J. Giaccia [Full author list] | Genes & Development [curation] | DOI: 10.1101/GAD.255000.114
PubMed: 25846796 | procollagen-proline 4-dioxygenase complex [curation]; Bone homeostasis [curation]; oxygen sensing [curation] | 2015-04-06 |
| The end of the hypoxic EPOch | [1]Todd A Aguilera, [2]Amato J. Giaccia [Full author list] | International Journal of Radiation Oncology Biology Physics [curation] | DOI: 10.1016/J.IJROBP.2015.01.041
PubMed: 25832683 | hypoxia [curation] | 2015-04-01 |
| Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells | [1]Elizabeth C Finger, [2]Laura Castellini, [3]Erinn B. Rankin, [4]Marta Vilalta, [5]Adam J. Krieg, [6]Dadi Jiang, [7]Alice Banh, [8]Wayne Zundel, [9]Marianne Broome Powell, [10]Amato J. Giaccia [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [curation] | DOI: 10.1073/PNAS.1418164112
PubMed: 25792458 | hypoxia [curation] | 2015-03-19 |
| Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function | [1]Dadi Jiang, [2]Edward L LaGory, [3]Daniela Kenzelmann Brož, [4]Kathryn T Bieging, [5]Colleen A Brady, [6]Nichole Link, [7]John M Abrams, [8]Amato J. Giaccia, [9]Laura D Attardi [Full author list] | Cell Reports [curation] | DOI: 10.1016/J.CELREP.2015.01.043
PubMed: 25704813 | | 2015-02-19 |
| Osteoblasts: a novel source of erythropoietin | [1]Colleen Wu, [2]Amato J. Giaccia, [3]Erinn B. Rankin [Full author list] | Current osteoporosis reports [curation] | DOI: 10.1007/S11914-014-0236-X
PubMed: 25204993 | erythropoietin [curation]; osteoblast [curation] | 2014-12-01 |
| Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus | [1]Christophe Merceron, [2]Laura Mangiavini, [3]Alexander Robling, [4]Tremika LeShan Wilson, [5]Amato J. Giaccia, [6]Irving M Shapiro, [7]Ernestina Schipani, [8]Makarand V Risbud [Full author list] | PLOS One [curation] | DOI: 10.1371/JOURNAL.PONE.0110768
PubMed: 25338007 | cell death [curation] | 2014-10-22 |
| An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis | [1]Mihalis S Kariolis, [2]Yu Rebecca Miao, [3]Douglas S Jones, [4]Shiven Kapur, [5]Irimpan I Mathews, [6]Amato J. Giaccia, [7]Jennifer R Cochran [Full author list] | Nature Chemical Biology [curation] | DOI: 10.1038/NCHEMBIO.1636
PubMed: 25242553 | | 2014-09-21 |
| Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response | [1]Peiwen Kuo, [2]Scott V Bratman, [3]David B. Shultz, [4]Rie von Eyben, [5]Cato Chan, [6]Ziwei Wang, [7]Carmen Say, [8]Aparna Gupta, [9]Bill W Loo, [10]Amato J. Giaccia, [11]Albert C. Koong, [12]Maximilian Diehn, [13]Quynh-Thu Le [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-14-1138
PubMed: 25189484 | lymphopenia [curation]; non-small-cell lung carcinoma [curation] | 2014-09-04 |
| Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET | [1]Erinn B. Rankin, [2]Katherine C Fuh, [3]Laura Castellini, [4]Kartik Viswanathan, [5]Elizabeth C Finger, [6]Anh N Diep, [7]Edward L LaGory, [8]Mihalis S Kariolis, [9]Andy Chan, [10]David Lindgren, [11]Håkan Axelson, [12]Yu R Miao, [13]Adam J. Krieg, [14]Amato J. Giaccia [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [curation] | DOI: 10.1073/PNAS.1404848111
PubMed: 25187556 | | 2014-09-03 |
| Neurotrophic factor GDNF promotes survival of salivary stem cells | [1]Nan Xiao, [2]Yuan Lin, [3]Hongbin Cao, [4]Davud Sirjani, [5]Amato J. Giaccia, [6]Albert C. Koong, [7]Christina S Kong, [8]Maximilian Diehn, [9]Quynh-Thu Le [Full author list] | Journal of Clinical Investigation [curation] | DOI: 10.1172/JCI74096
PubMed: 25036711 | | 2014-07-18 |
| Recruitment of circulating breast cancer cells is stimulated by radiotherapy | [1]Marta Vilalta, [2]Marjan Rafat, [3]Amato J. Giaccia, [4]Edward E Graves [Full author list] | Cell Reports [curation] | DOI: 10.1016/J.CELREP.2014.06.011
PubMed: 25017065 | breast cancer [curation]; radiation therapy [curation] | 2014-07-10 |
| Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development | [1]Laura Mangiavini, [2]Christophe Merceron, [3]Elisa Araldi, [4]Richa Khatri, [5]Rita Gerard-O'Riley, [6]Tremika LeShan Wilson, [7]Erinn B. Rankin, [8]Amato J. Giaccia, [9]Ernestina Schipani [Full author list] | Developmental Biology [curation] | DOI: 10.1016/J.YDBIO.2014.06.013
PubMed: 24972088 | | 2014-06-24 |
| PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2 | [1]Cullen M Taniguchi, [2]Yu Rebecca Miao, [3]Anh N Diep, [4]Colleen Wu, [5]Erinn B. Rankin, [6]Todd F Atwood, [7]Lei Xing, [8]Amato J. Giaccia [Full author list] | Science Translational Medicine [curation] | DOI: 10.1126/SCITRANSLMED.3008523
PubMed: 24828078 | toxicity [curation] | 2014-05-01 |
| Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury | [1]Andrew S Zimmermann, [2]Shane D Morrison, [3]Michael S Hu, [4]Shuli Li, [5]Allison Nauta, [6]Michael Sorkin, [7]Nathaniel P Meyer, [8]Graham G Walmsley, [9]Zeshaan N Maan, [10]Denise A Chan, [11]Geoffrey C. Gurtner, [12]Amato J. Giaccia, [13]Michael T Longaker [Full author list] | PLOS One [curation] | DOI: 10.1371/JOURNAL.PONE.0093373
PubMed: 24695462 | wound healing [curation] | 2014-04-02 |
| Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. | [1]Constantinos Koumenis, [2]Ester M Hammond, [3]Amato J. Giaccia [Full author list] | Advances in Experimental Medicine and Biology [curation] | DOI: 10.1007/978-1-4614-5915-6
PubMed: 24765667 | | 2014-01-01 |
| Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents | [1]Muriel Bonnet, [2]Jack U Flanagan, [3]Denise A Chan, [4]Amato J. Giaccia, [5]Michael P. Hay [Full author list] | Bioorganic & Medicinal Chemistry [curation] | DOI: 10.1016/J.BMC.2013.12.028
PubMed: 24387866 | renal cell carcinoma [curation] | 2013-12-20 |
| The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells | [1]Olga V Razorenova, [2]Laura Castellini, [3]Renata Colavitti, [4]Laura E. Edgington, [5]Monica Nicolau, [6]Xin Huang, [7]Barbara Bedogni, [8]Edward M Mills, [9]Matthew Bogyo, [10]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.00644-12
PubMed: 24344197 | | 2013-12-16 |
| Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes | [1]Cullen M Taniguchi, [2]Elizabeth C Finger, [3]Adam J. Krieg, [4]Colleen Wu, [5]Anh N Diep, [6]Edward L LaGory, [7]Kevin Wei, [8]Lisa McGinnis, [9]Jenny Yuan, [10]Calvin J Kuo, [11]Amato J. Giaccia [Full author list] | Nature Medicine [curation] | DOI: 10.1038/NM.3294
PubMed: 24037093 | hypoxia [curation]; preproinsulin [curation] | 2013-09-15 |
| A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition | [1]Kevin Wei, [2]Stephanie M Piecewicz, [3]Lisa McGinnis, [4]Cullen M Taniguchi, [5]Stanley J Wiegand, [6]Keith Anderson, [7]Carol W-M Chan, [8]Kimberly X Mulligan, [9]David Kuo, [10]Jenny Yuan, ..., [19]Owen Patrick McGuinness, [20]Gavin Thurston, [21]Amato J. Giaccia, [22]Calvin J Kuo [Full author list] | Nature Medicine [curation] | DOI: 10.1038/NM.3295
PubMed: 24037094 | preproinsulin [curation] | 2013-09-15 |
| Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis | [1]Ernestina Schipani, [2]Collen Wu, [3]Erinn B. Rankin, [4]Amato J. Giaccia [Full author list] | Frontiers in Endocrinology [curation] | DOI: 10.3389/FENDO.2013.00085
PubMed: 23847596 | osteoblast [curation] | 2013-07-10 |
| A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth | [1]Nan Xiao, [2]Hongbin Cao, [3]Che-Hong Chen, [4]Christina S Kong, [5]Rehan Ali, [6]Cato Chan, [7]Davud Sirjani, [8]Edward Graves, [9]Albert C. Koong, [10]Amato J. Giaccia, [11]Daria Mochly-Rosen, [12]Quynh-Thu Le [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-13-0127
PubMed: 23812668 | | 2013-06-28 |
| A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth | [1]Edward L LaGory, [2]Amato J. Giaccia [Full author list] | Cell Cycle [curation] | DOI: 10.4161/CC.23948
PubMed: 23422857 | | 2013-02-19 |
| AXL Expression and Risk of Relapse in Non-Small Cell Lung Cancer | [1]Marius Lund-Iversen, [2]Erinn Rankin, [3]Amato J. Giaccia, [4]Rebecca Yu Miao, [5]Quynh-Thu Le, [6]Âslaug Helland, [7]Odd Terje Brustugun [Full author list] | American Journal of Clinical Pathology [curation] | DOI: 10.1093/AJCP/138.SUPPL2.219
| non-small-cell lung carcinoma [curation] | 2012-11-01 |
| Blood and bones: osteoblastic HIF signaling regulates erythropoiesis | [1]Colleen Wu, [2]Erinn B. Rankin, [3]Amato J. Giaccia [Full author list] | Cell Cycle [curation] | DOI: 10.4161/CC.20635
PubMed: 22627672 | | 2012-06-15 |
| The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. | [1]Erinn B. Rankin, [2]Colleen Wu, [3]Richa Khatri, [4]Tremika L S Wilson, [5]Rebecca Andersen, [6]Elisa Araldi, [7]Andrew L Rankin, [8]Jenny Yuan, [9]Calvin J Kuo, [10]Ernestina Schipani, [11]Amato J. Giaccia [Full author list] | Cell [curation] | DOI: 10.1016/J.CELL.2012.01.051
PubMed: 22464323 | osteoblast [curation] | 2012-03-01 |
| VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. | [1]Christa Maes, [2]Elisa Araldi, [3]Katharina Haigh, [4]Richa Khatri, [5]Riet Van Looveren, [6]Amato J. Giaccia, [7]Jody J Haigh, [8]Geert Carmeliet, [9]Ernestina Schipani [Full author list] | Journal of Bone and Mineral Research [curation] | DOI: 10.1002/JBMR.1487
PubMed: 22162090 | cartilage [curation] | 2012-03-01 |
| Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality | [1]Denise A Chan, [2]Patrick D Sutphin, [3]Phuong Nguyen, [4]Sandra Turcotte, [5]Edwin W Lai, [6]Alice Banh, [7]Gloria E Reynolds, [8]Jen-Tsan Chi, [9]Jason Wu, [10]David E Solow-Cordero, [11]Muriel Bonnet, [12]Jack U Flanagan, [13]Donna M Bouley, [14]Edward E Graves, [15]Bill Denny, [16]Michael P Hay, [17]Amato J. Giaccia [Full author list] | Science Translational Medicine [curation] | DOI: 10.1126/SCITRANSLMED.3002394
PubMed: 21813754 | renal cell carcinoma [curation] | 2011-08-01 |
| A central role for hypoxic signaling in cartilage, bone, and hematopoiesis | [1]Erinn B. Rankin, [2]Amato J. Giaccia, [3]Ernestina Schipani [Full author list] | Current osteoporosis reports [curation] | DOI: 10.1007/S11914-011-0047-2
PubMed: 21360287 | hypoxia [curation]; cartilage [curation]; hemopoiesis [curation] | 2011-06-01 |
| Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis | [1]Alice Banh, [2]Jing Zhang, [3]Hongbin Cao, [4]Donna M Bouley, [5]Shirley Kwok, [6]Christina Kong, [7]Amato J. Giaccia, [8]Albert C. Koong, [9]Quynh-Thu Le [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-10-4157
PubMed: 21546572 | apoptotic process [curation] | 2011-05-05 |
| SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells | [1]Muriel Bonnet, [2]Jack U Flanagan, [3]Denise A Chan, [4]Edwin W Lai, [5]Phuong Nguyen, [6]Amato J. Giaccia, [7]Michael P. Hay [Full author list] | Bioorganic & Medicinal Chemistry [curation] | DOI: 10.1016/J.BMC.2011.04.042
PubMed: 21561782 | autophagy [curation]; renal cell carcinoma [curation]; cell death [curation] | 2011-04-24 |
| Hypoxia and senescence: the impact of oxygenation on tumor suppression | [1]Scott M Welford, [2]Amato J. Giaccia [Full author list] | Molecular Cancer Research [curation] | DOI: 10.1158/1541-7786.MCR-11-0065
PubMed: 21385881 | hypoxia [curation] | 2011-03-08 |
| VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration | [1]Olga V Razorenova, [2]Elizabeth C Finger, [3]Renata Colavitti, [4]Sophia B Chernikova, [5]Alexander D Boiko, [6]Charles K F Chan, [7]Adam J. Krieg, [8]Barbara Bedogni, [9]Edward LaGory, [10]Irving Weissman, [11]Marianne Broome-Powell, [12]Amato J. Giaccia [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [curation] | DOI: 10.1073/PNAS.1011777108
PubMed: 21233420 | cell migration [curation]; renal cell carcinoma [curation] | 2011-01-13 |
| Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development | [1]Elisa Araldi, [2]Richa Khatri, [3]Amato J. Giaccia, [4]M Celeste Simon, [5]Ernestina Schipani [Full author list] | Nature Medicine [curation] | DOI: 10.1038/NM0111-25
PubMed: 21217667 | | 2011-01-01 |
| AXL is an essential factor and therapeutic target for metastatic ovarian cancer | [1]Erinn B. Rankin, [2]Katherine C Fuh, [3]Tiffany E Taylor, [4]Adam J. Krieg, [5]Margaret Musser, [6]Jenny Yuan, [7]Kevin Wei, [8]Calvin J Kuo, [9]Teri A Longacre, [10]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-10-1267
PubMed: 20858715 | ovarian cancer [curation] | 2010-09-21 |
| Hypoxia in models of lung cancer: implications for targeted therapeutics | [1]Edward E Graves, [2]Marta Vilalta, [3]Ivana K Cecic, [4]Janine Terra Erler, [5]Phuoc T. Tran, [6]Dean Felsher, [7]Leanne Sayles, [8]Alejandro Sweet-Cordero, [9]Quynh-Thu Le, [10]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-10-1206
PubMed: 20858837 | lung cancer [curation]; hypoxia [curation] | 2010-09-21 |
| Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling | [1]Mandi Wiley, [2]Kristin R Sweeney, [3]Denise A Chan, [4]Kevin M Brown, [5]Curtis McMurtrey, [6]Eric W Howard, [7]Amato J. Giaccia, [8]Ira J Blader [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M110.147041
PubMed: 20581113 | hypoxia [curation]; Toxoplasma gondii [curation] | 2010-06-25 |
| Hypoxia, inflammation, and the tumor microenvironment in metastatic disease | [1]Elizabeth C Finger, [2]Amato J. Giaccia [Full author list] | Cancer and Metastasis Reviews [curation] | DOI: 10.1007/S10555-010-9224-5
PubMed: 20393783 | hypoxia [curation] | 2010-06-01 |
| MiR-210--micromanager of the hypoxia pathway | [1]Xin Huang, [2]Quynh-Thu Le, [3]Amato J. Giaccia [Full author list] | Trends in Molecular Medicine [curation] | DOI: 10.1016/J.MOLMED.2010.03.004
PubMed: 20434954 | hypoxia [curation] | 2010-05-01 |
| The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways | [1]Donald Courter, [2]Hongbin Cao, [3]Shirley Kwok, [4]Christina Kong, [5]Alice Banh, [6]Peiwen Kuo, [7]Donna M Bouley, [8]Carmen Vice, [9]Odd Terje Brustugun, [10]Nicholas C Denko, [11]Albert C. Koong, [12]Amato J. Giaccia, [13]Quynh-Thu Le [Full author list] | PLOS One [curation] | DOI: 10.1371/JOURNAL.PONE.0009633
PubMed: 20224789 | | 2010-03-10 |
| Targeting cancer cells through autophagy for anticancer therapy | [1]Sandra Turcotte, [2]Amato J. Giaccia [Full author list] | Current Opinion in Cell Biology [curation] | DOI: 10.1016/J.CEB.2009.12.007
PubMed: 20056398 | autophagy [curation] | 2010-01-06 |
| Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth | [1]Adam J. Krieg, [2]Erinn B. Rankin, [3]Denise Chan, [4]Olga Razorenova, [5]Sully Fernandez, [6]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.00444-09
PubMed: 19858293 | hypoxia [curation] | 2010-01-01 |
| 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death | [1]Michael P. Hay, [2]Sandra Turcotte, [3]Jack U Flanagan, [4]Muriel Bonnet, [5]Denise A Chan, [6]Patrick D Sutphin, [7]Phuong Nguyen, [8]Amato J. Giaccia, [9]Bill Denny [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/JM901457W
PubMed: 19994864 | autophagy [curation]; renal cell carcinoma [curation]; cell death [curation] | 2010-01-01 |
| Role of carcinoma-associated fibroblasts and hypoxia in tumor progression | [1]Amato J. Giaccia, [2]Ernestina Schipani [Full author list] | Current Topics in Microbiology and Immunology [curation] | DOI: 10.1007/82_2010_73
PubMed: 20517716 | hypoxia [curation]; tumor progression [curation] | 2010-01-01 |
| Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells | [1]Yue Xu, [2]Kyle E Hammerick, [3]Aaron W James, [4]Antoine L Carre, [5]Philipp Leucht, [6]Amato J. Giaccia, [7]Michael T Longaker [Full author list] | Tissue Engineering. Part A [curation] | DOI: 10.1089/TEN.TEA.2009.0213
PubMed: 19505250 | | 2009-12-01 |
| Matrix crosslinking forces tumor progression by enhancing integrin signaling | [1]Kandice R. Levental, [2]Hongmei Yu, [3]Laura Kass, [4]Johnathon N Lakins, [5]Mikala Egeblad, [6]Janine T. Erler, [7]Sheri F T Fong, [8]Katalin Csiszar, [9]Amato J. Giaccia, [10]Wolfgang Weninger, [11]Mitsuo Yamauchi, [12]David L Gasser, [13]Valerie M Weaver [Full author list] | Cell [curation] | DOI: 10.1016/J.CELL.2009.10.027
PubMed: 19931152 | tumor progression [curation] | 2009-11-25 |
| Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104 | [1]Rob A Cairns, [2]Kevin L Bennewith, [3]Edward E Graves, [4]Amato J. Giaccia, [5]Daniel T Chang, [6]Nicholas C Denko [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-09-1676
PubMed: 19920111 | hypoxia [curation]; pharmacology [curation]; positron emission tomography [curation] | 2009-11-17 |
| Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours | [1]Carlotta Granchi, [2]Tiziana Funaioli, [3]Janine T. Erler, [4]Amato J. Giaccia, [5]Marco Macchia, [6]Filippo Minutolo [Full author list] | ChemMedChem [curation] | DOI: 10.1002/CMDC.200900247
PubMed: 19685543 | hypoxia [curation] | 2009-10-01 |
| Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation | [1]Xin Huang, [2]Lianghao Ding, [3]Kevin L Bennewith, [4]Ricky T Tong, [5]Scott M Welford, [6]Kie-Kian Ang, [7]Michael Story, [8]Quynh-Thu Le, [9]Amato J. Giaccia [Full author list] | Molecular Cell [curation] | DOI: 10.1016/J.MOLCEL.2009.09.006
PubMed: 19782034 | cell biology [curation]; hypoxia [curation]; Hypoxia inducible factor 1 subunit alpha [curation]; tumor initiation [curation]; positive regulation of pri-miRNA transcription by RNA polymerase II [curation] | 2009-09-01 |
| Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. | [1]Quynh-Thu Le, [2]Jonathan Harris, [3]Anthony M Magliocco, [4]Christina S Kong, [5]Roman Diaz, [6]Brian Shin, [7]Hongbin Cao, [8]Andy Trotti, [9]Janine Terra Erler, [10]Christine H Chung, [11]Adam P. Dicker, [12]Thomas F Pajak, [13]Amato J. Giaccia, [14]Kie-Kian Ang [Full author list] | Journal of Clinical Oncology [curation] | DOI: 10.1200/JCO.2008.20.6003
PubMed: 19667273 | radiation therapy [curation]; head and neck squamous cell carcinoma [curation] | 2009-08-10 |
| Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment | [1]Denise A Chan, [2]Tiara L A Kawahara, [3]Patrick D Sutphin, [4]Howard Y Chang, [5]Jen-Tsan Chi, [6]Amato J. Giaccia [Full author list] | Cancer Cell [curation] | DOI: 10.1016/J.CCR.2009.04.010
PubMed: 19477431 | angiogenesis [curation]; bone marrow [curation] | 2009-06-01 |
| Bringing H2AX into the angiogenesis family | [1]Erinn B. Rankin, [2]Amato J. Giaccia, [3]Ester M Hammond [Full author list] | Cancer Cell [curation] | DOI: 10.1016/J.CCR.2009.05.004
PubMed: 19477424 | | 2009-06-01 |
| The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth | [1]Kevin L Bennewith, [2]Xin Huang, [3]Christine M Ham, [4]Edward E Graves, [5]Janine Terra Erler, [6]Neeraja Kambham, [7]Jonathan Feazell, [8]George P Yang, [9]Albert C. Koong, [10]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-08-0987
PubMed: 19179545 | connective tissue [curation] | 2009-02-01 |
| Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche | [1]Janine Terra Erler, [2]Kevin L Bennewith, [3]Thomas R Cox, [4]Georgina Lang, [5]Demelza Bird, [6]Albert C. Koong, [7]Quynh-Thu Le, [8]Amato J. Giaccia [Full author list] | Cancer Cell [curation] | DOI: 10.1016/J.CCR.2008.11.012
PubMed: 19111879 | cell biology [curation]; hypoxia [curation]; bone marrow [curation] | 2009-01-06 |
| ATM activation and signaling under hypoxic conditions | [1]Zuzana Bencokova, [2]Muriel R Kaufmann, [3]Isabel M Pires, [4]Philip S Lecane, [5]Amato J. Giaccia, [6]Ester M Hammond [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.01301-08
PubMed: 18981219 | hypoxia [curation] | 2008-11-03 |
| Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death | [1]Sandra Turcotte, [2]Patrick D Sutphin, [3]Amato J. Giaccia [Full author list] | Autophagy [curation] | DOI: 10.4161/AUTO.6785
PubMed: 18769110 | autophagy [curation]; renal cell carcinoma [curation]; cell death [curation] | 2008-10-13 |
| Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics | [1]Denise A Chan, [2]Amato J. Giaccia [Full author list] | Cell Cycle [curation] | DOI: 10.4161/CC.7.19.6776
PubMed: 18818511 | autophagy [curation] | 2008-10-12 |
| A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy | [1]Sandra Turcotte, [2]Denise A Chan, [3]Patrick D Sutphin, [4]Michael P Hay, [5]Bill Denny, [6]Amato J. Giaccia [Full author list] | Cancer Cell [curation] | DOI: 10.1016/J.CCR.2008.06.004
PubMed: 18598947 | autophagy [curation]; renal cell carcinoma [curation] | 2008-07-01 |
| Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice | [1]Clara Y H Choi, [2]Denise A Chan, [3]Ramasamy Paulmurugan, [4]Patrick D Sutphin, [5]Quynh-Thu Le, [6]Albert C Koong, [7]Wayne Zundel, [8]Sanjiv S Gambhir, [9]Amato J. Giaccia [Full author list] | Molecular imaging : official journal of the Society for Molecular Imaging [curation] | PubMed: 19123984 | hypoxia [curation] | 2008-05-01 |
| The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation | [1]Shashwati Basak, [2]Suzanne B R Jacobs, [3]Adam J Krieg, [4]Navneeta Pathak, [5]Qi Zeng, [6]Philipp Kaldis, [7]Amato J. Giaccia, [8]Laura D Attardi [Full author list] | Molecular Cell [curation] | DOI: 10.1016/J.MOLCEL.2008.04.002
PubMed: 18471976 | | 2008-05-01 |
| In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis | [1]Yue Xu, [2]Preeti Malladi, [3]Michael Chiou, [4]Elena Bekerman, [5]Amato J. Giaccia, [6]Michael T Longaker [Full author list] | Tissue Engineering [curation] | DOI: 10.1089/TEN.2007.0050
PubMed: 17916040 | hypoxia [curation]; cartilage development [curation] | 2007-12-01 |
| Oxygen sensing and the DNA-damage response | [1]Ester M Hammond, [2]Muriel R Kaufmann, [3]Amato J. Giaccia [Full author list] | Current Opinion in Cell Biology [curation] | DOI: 10.1016/J.CEB.2007.10.002
PubMed: 18023567 | DNA damage [curation]; oxygen sensing [curation] | 2007-11-26 |
| Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia | [1]Eric I Chang, [2]Shang A Loh, [3]Daniel J Ceradini, [4]Edward I Chang, [5]Shin-e Lin, [6]Nicholas Bastidas, [7]Shahram Aarabi, [8]Denise A Chan, [9]Michael L Freedman, [10]Amato J. Giaccia, [11]Geoffrey C. Gurtner [Full author list] | Circulation [curation] | DOI: 10.1161/CIRCULATIONAHA.107.715847
PubMed: 18040029 | hypoxia [curation]; endothelium [curation] | 2007-11-26 |
| Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion | [1]Elisabeth L Pagé, [2]Denise A Chan, [3]Amato J. Giaccia, [4]Mark Levine, [5]Darren E Richard [Full author list] | Molecular Biology of the Cell [curation] | DOI: 10.1091/MBC.E07-06-0612
PubMed: 17942596 | hypoxia [curation] | 2007-10-17 |
| Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas | [1]Quynh-Thu Le, [2]Christina Kong, [3]Phillip W Lavori, [4]Ken O'byrne, [5]Janine Terra Erler, [6]Xin Huang, [7]Yijun Chen, [8]Hongbin Cao, [9]Robert Tibshirani, [10]Nic Denko, [11]Amato J. Giaccia, [12]Albert C. Koong [Full author list] | International Journal of Radiation Oncology Biology Physics [curation] | DOI: 10.1016/J.IJROBP.2007.01.071
PubMed: 17707270 | hypoxia [curation] | 2007-09-01 |
| Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia | [1]Ivana Cecic, [2]Denise A Chan, [3]Patrick D Sutphin, [4]Pritha Ray, [5]Sanjiv Sam Gambhir, [6]Amato J. Giaccia, [7]Edward E Graves [Full author list] | Molecular imaging : official journal of the Society for Molecular Imaging [curation] | DOI: 10.2310/7290.2007.00017
PubMed: 17711777 | | 2007-07-01 |
| Hypoxia, gene expression, and metastasis | [1]Denise A Chan, [2]Amato J. Giaccia [Full author list] | Cancer and Metastasis Reviews [curation] | DOI: 10.1007/S10555-007-9063-1
PubMed: 17458506 | hypoxia [curation] | 2007-06-01 |
| Energy regulation: HIF MXIes it up with the C-MYC powerhouse | [1]Patrick D Sutphin, [2]Amato J. Giaccia, [3]Denise A Chan [Full author list] | Developmental Cell [curation] | DOI: 10.1016/J.DEVCEL.2007.05.006
PubMed: 17543856 | | 2007-06-01 |
| Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells | [1]Patrick D Sutphin, [2]Denise A Chan, [3]James M Li, [4]Sandra Turcotte, [5]Adam J. Krieg, [6]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-07-0604
PubMed: 17575159 | renal cell carcinoma [curation] | 2007-06-01 |
| Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells. | [1]Preeti Malladi, [2]Yue Xu, [3]Michael Chiou, [4]Amato J. Giaccia, [5]Michael T Longaker [Full author list] | Tissue Engineering [curation] | DOI: 10.1089/TEN.2006.0265
PubMed: 17518738 | hypoxia [curation]; cartilage development [curation] | 2007-06-01 |
| HIF gene expression in cancer therapy | [0]Adam J. Krieg, [1]Denise A Chan, [2]Adam J Krieg, [3]Sandra Turcotte, [4]Amato J. Giaccia [Full author list] | Methods in Enzymology [curation] | DOI: 10.1016/S0076-6879(07)35016-7
PubMed: 17998061 | | 2007-01-01 |
| HIF1alpha delays premature senescence through the activation of MIF. | [1]Scott M Welford, [2]Barbara Bedogni, [3]Katarina Gradin, [4]Lorenz Poellinger, [5]Marianne Broome Powell, [6]Amato J. Giaccia [Full author list] | Genes & Development [curation] | DOI: 10.1101/GAD.1471106
PubMed: 17142669 | | 2006-12-01 |
| Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro | [1]Yi Pan, [2]Kyle D Mansfield, [3]Cara C Bertozzi, [4]Viktoriya Rudenko, [5]Denise A Chan, [6]Amato J. Giaccia, [7]M Celeste Simon [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.01223-06
PubMed: 17101781 | hypoxia [curation] | 2006-11-13 |
| Lysyl oxidase mediates hypoxic control of metastasis | [1]Janine T. Erler, [2]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-06-3197
PubMed: 17079439 | hypoxia [curation] | 2006-11-01 |
| Plasma osteopontin is an independent prognostic marker for head and neck cancers | [1]David Petrik, [2]Philip W Lavori, [3]Hongbin Cao, [4]Yonghua Zhu, [5]Priscilla Wong, [6]Erin Christofferson, [7]Michael J Kaplan, [8]Harlan A Pinto, [9]Patrick Sutphin, [10]Albert C. Koong, [11]Amato J. Giaccia, [12]Quynh-Thu Le [Full author list] | Journal of Clinical Oncology [curation] | DOI: 10.1200/JCO.2006.06.8627
PubMed: 17114663 | | 2006-11-01 |
| Functional analysis of p53 binding under differential stresses | [0]Adam J. Krieg, [1]Adam J Krieg, [2]Ester M Hammond, [3]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.00322-06
PubMed: 16980608 | | 2006-10-01 |
| Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? | [1]Ester M Hammond, [2]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-06-0613
PubMed: 16951213 | | 2006-09-01 |
| Checking in on hypoxia/reoxygenation | [1]Rachel A Freiberg, [2]Adam J Krieg, [3]Amato J. Giaccia, [4]Ester M Hammond [Full author list] | Cell Cycle [curation] | DOI: 10.4161/CC.5.12.2811
PubMed: 16760660 | hypoxia [curation] | 2006-06-15 |
| Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis | [1]Nadja Dornhöfer, [2]Suzanne Spong, [3]Kevin Bennewith, [4]Ali Salim, [5]Stephen Klaus, [6]Neeraja Kambham, [7]Carol Wong, [8]Fiona Kaper, [9]Patrick Sutphin, [10]Randall Nacamuli, [11]Michael Höckel, [12]Quynh Le, [13]Michael Longaker, [14]George Yang, [15]Albert C. Koong, [16]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-06-0081
PubMed: 16740721 | connective tissue [curation]; monoclonal antibody [curation] | 2006-06-01 |
| Genome-wide analysis of p53 under hypoxic conditions | [1]Ester M Hammond, [2]Daniel J Mandell, [3]Ali Salim, [4]Adam J. Krieg, [5]Thomas M Johnson, [6]Haider A Shirazi, [7]Laura D Attardi, [8]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.26.9.3492-3504.2006
PubMed: 16611991 | hypoxia [curation] | 2006-05-01 |
| RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis | [1]Janine Terra Erler, [2]Kevin L Bennewith, [3]Monica Nicolau, [4]Nadja Dornhöfer, [5]Christina Kong, [6]Quynh-Thu Le, [7]Jen-Tsan Ashley Chi, [8]Stefanie S Jeffrey, [9]Amato J. Giaccia [Full author list] | Nature [curation] | DOI: 10.1038/NATURE04695
PubMed: 16642001 | hypoxia [curation] | 2006-04-27 |
| Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers | [1]Jen-Tsan Chi, [2]Zhen Wang, [3]Dimitry S A Nuyten, [4]Edwin H Rodriguez, [5]Marci E Schaner, [6]Ali Salim, [7]Yun Wang, [8]Gunnar B Kristensen, [9]Åslaug Helland, [10]Anne-Lise Børresen-Dale, [11]Amato J. Giaccia, [12]Michael T Longaker, [13]Trevor Hastie, [14]George P Yang, [15]Marc van de Vijver, [16]Patrick O. Brown [Full author list] | PLOS MEDICINE [curation] | DOI: 10.1371/JOURNAL.PMED.0030047
PubMed: 16417408 | hypoxia [curation] | 2006-03-01 |
| DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response | [1]Rachel A Freiberg, [2]Ester M Hammond, [3]Mary Jo Dorie, [4]Scott M Welford, [5]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.26.5.1598-1609.2006
PubMed: 16478982 | DNA damage [curation] | 2006-03-01 |
| An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. | [1]Quynh-Thu Le, [2]Eunice Chen, [3]Ali Salim, [4]Hongbin Cao, [5]Christina S Kong, [6]Richard Whyte, [7]Jessica Donington, [8]Walter Cannon, [9]Heather Wakelee, [10]Robert Tibshirani, [11]John D Mitchell, [12]Donna Richardson, [13]Ken J O'Byrne, [14]Albert C. Koong, [15]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | DOI: 10.1158/1078-0432.CCR-05-2049
PubMed: 16533775 | patient [curation] | 2006-03-01 |
| Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions | [1]Fiona Kaper, [2]Nadja Dornhoefer, [3]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-05-3375
PubMed: 16452213 | sirolimus [curation]; hypoxia [curation] | 2006-02-01 |
| The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels | [1]Wade Spear, [2]Denise Chan, [3]Isabelle Coppens, [4]Randall S Johnson, [5]Amato J. Giaccia, [6]Ira J Blader [Full author list] | Cellular Microbiology [curation] | DOI: 10.1111/J.1462-5822.2005.00628.X
PubMed: 16441443 | hypoxia [curation]; Toxoplasma gondii [curation] | 2006-02-01 |
| Comment on: osteopontin as toxic marker | [1]Quynh-Thu Le, [2]Hongbin Cao, [3]Albert C. Koong, [4]Amato J. Giaccia [Full author list] | Radiotherapy and Oncology [curation] | DOI: 10.1016/J.RADONC.2005.12.011
PubMed: 16442647 | | 2006-01-26 |
| Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells | [1]Preeti Malladi, [2]Yue Xu, [3]Michael Chiou, [4]Amato J. Giaccia, [5]Michael T Longaker [Full author list] | American Journal of Physiology - Cell Physiology [curation] | DOI: 10.1152/AJPCELL.00415.2005
PubMed: 16291817 | cartilage development [curation] | 2005-11-16 |
| Galectin-1: a link between tumor hypoxia and tumor immune privilege | [1]Quynh-Thu Le, [2]Gongyi Shi, [3]Hongbin Cao, [4]Daniel W Nelson, [5]Yingyun Wang, [6]Eunice Y Chen, [7]Shuchun Zhao, [8]Christina Kong, [9]Donna Richardson, [10]Ken J O'Byrne, [11]Amato J. Giaccia, [12]Albert C Koong [Full author list] | Journal of Clinical Oncology [curation] | DOI: 10.1200/JCO.2005.02.0206
PubMed: 16219933 | hypoxia [curation] | 2005-10-11 |
| Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer | [1]Yonghua Zhu, [2]David T Denhardt, [3]Hongbin Cao, [4]Patrick D Sutphin, [5]Albert C. Koong, [6]Amato J. Giaccia, [7]Quynh-Thu Le [Full author list] | Oncogene [curation] | DOI: 10.1038/SJ.ONC.1208800
PubMed: 16007184 | hypoxia [curation] | 2005-09-01 |
| The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation | [1]Ester M Hammond, [2]Rachel A Freiberg, [3]Amato J. Giaccia [Full author list] | Cancer Letters [curation] | DOI: 10.1016/J.CANLET.2005.06.029
PubMed: 16085356 | | 2005-08-08 |
| Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha | [1]Denise A Chan, [2]Patrick D Sutphin, [3]Shing-Erh Yen, [4]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.25.15.6415-6426.2005
PubMed: 16024780 | hypoxia [curation] | 2005-08-01 |
| A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia | [1]Daniel W Nelson, [2]Hongbin Cao, [3]Yonghua Zhu, [4]Bulbin Sunar-Reeder, [5]Clara Y H Choi, [6]James D Faix, [7]J Martin Brown, [8]Albert C Koong, [9]Amato J. Giaccia, [10]Quynh-Thu Le [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-04-2602
PubMed: 16024616 | hypoxia [curation]; xenograft [curation] | 2005-07-01 |
| The role of p53 in hypoxia-induced apoptosis | [1]Ester M Hammond, [2]Amato J. Giaccia [Full author list] | Biochemical and Biophysical Research Communications [curation] | DOI: 10.1016/J.BBRC.2005.03.154
PubMed: 15865928 | hypoxia [curation]; apoptotic process [curation] | 2005-06-01 |
| Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment | [1]Ioanna Papandreou, [2]Chaya Krishna, [3]Fiona Kaper, [4]Deli Cai, [5]Amato J. Giaccia, [6]Nicholas C Denko [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-04-3395
PubMed: 15833847 | | 2005-04-01 |
| Angiogenesis is required for successful bone induction during distraction osteogenesis | [1]Tony D Fang, [2]Ali Salim, [3]Wei Xia, [4]Randall P Nacamuli, [5]Samira Guccione, [6]HanJoon M Song, [7]Richard A Carano, [8]Ellen H Filvaroff, [9]Mark D Bednarski, [10]Amato J. Giaccia, [11]Michael T Longaker [Full author list] | Journal of Bone and Mineral Research [curation] | DOI: 10.1359/JBMR.050301
PubMed: 15940364 | angiogenesis [curation] | 2005-03-07 |
| The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality | [1]Thomas M Johnson, [2]Ester M Hammond, [3]Amato J. Giaccia, [4]Laura D Attardi [Full author list] | Nature Genetics [curation] | DOI: 10.1038/NG1498
PubMed: 15654339 | apoptotic process [curation] | 2005-01-16 |
| Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling | [1]Yijun Chen, [2]Gongyi Shi, [3]Wei Xia, [4]Christina Kong, [5]Shuchun Zhao, [6]Allison F Gaw, [7]Eunice Y Chen, [8]George P Yang, [9]Amato J. Giaccia, [10]Quynh-Thu Le, [11]Albert C. Koong [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-04-0899
PubMed: 15492250 | head and neck cancer [curation]; head and neck carcinoma [curation]; neck cancer [curation] | 2004-10-01 |
| Developmental response to hypoxia | [1]S-T Joseph Huang, [2]Kim Chi T Vo, [3]Deirdre J Lyell, [4]Gerarda H Faessen, [5]Suzana Tulac, [6]Robert Tibshirani, [7]Amato J. Giaccia, [8]Linda Giudice [Full author list] | FASEB Journal [curation] | DOI: 10.1096/FJ.03-1377COM
PubMed: 15333578 | hypoxia [curation] | 2004-09-01 |
| Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation | [1]Ester M Hammond, [2]Mary Jo Dorie, [3]Amato J. Giaccia [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-04-1520
PubMed: 15374968 | hypoxia [curation] | 2004-09-01 |
| XBP1 is essential for survival under hypoxic conditions and is required for tumor growth | [1]Lorenzo Romero-Ramírez, [2]Hongbin Cao, [3]Daniel Nelson, [4]Ester Hammond, [5]Ann-Hwee Lee, [6]Hiderou Yoshida, [7]Kazutoshi Mori, [8]Laurie Glimcher, [9]Nicholas C Denko, [10]Amato J. Giaccia, [11]Quynh-Thu Le, [12]Albert C. Koong [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-04-1606
PubMed: 15342372 | hypoxia [curation] | 2004-09-01 |
| JunD reduces tumor angiogenesis by protecting cells from oxidative stress | [1]Damien Gerald, [2]Edurne Berra, [3]Yves M Frapart, [4]Denise A Chan, [5]Amato J. Giaccia, [6]Daniel Mansuy, [7]Jacques Pouysségur, [8]Moshe Yaniv, [9]Fatima Mechta-Grigoriou [Full author list] | Cell [curation] | DOI: 10.1016/J.CELL.2004.08.025
PubMed: 15369676 | angiogenesis [curation]; tumor angiogenesis [curation] | 2004-09-01 |
| Hypoxic gene expression and metastasis | [1]Quynh-Thu Le, [2]Nicholas C Denko, [3]Amato J. Giaccia [Full author list] | Cancer and Metastasis Reviews [curation] | DOI: 10.1023/B:CANC.0000031768.89246.D7
PubMed: 15197330 | hypoxia [curation] | 2004-08-01 |
| The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation | [1]Ester M Hammond, [2]Amato J. Giaccia [Full author list] | DNA Repair [curation] | DOI: 10.1016/J.DNAREP.2004.03.035
PubMed: 15279800 | hypoxia [curation] | 2004-08-01 |
| Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts | [1]Ali Salim, [2]Randall P Nacamuli, [3]Elise F Morgan, [4]Amato J. Giaccia, [5]Michael T Longaker [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M403715200
PubMed: 15263007 | osteoblast [curation] | 2004-07-19 |
| The hypoxic tumor microenvironment and gene expression | [1]Cornelia Leo, [2]Amato J. Giaccia, [3]Nicholas C Denko [Full author list] | Seminars in Radiation Oncology [curation] | DOI: 10.1016/J.SEMRADONC.2004.04.007
PubMed: 15254863 | hypoxia [curation] | 2004-07-01 |
| Stem cell differentiation. | [1]Ali Salim, [2]Amato J. Giaccia, [3]Michael T Longaker [Full author list] | Nature Biotechnology [curation] | DOI: 10.1038/NBT0704-804
PubMed: 15229534 | stem cell differentiation [curation] | 2004-07-01 |
| Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5 | [1]Lynne Bemis, [2]Denise A Chan, [3]Carla V Finkielstein, [4]Lin Qi, [5]Patrick D Sutphin, [6]Xiaojiang Chen, [7]Kurt Stenmark, [8]Amato J. Giaccia, [9]Wayne Zundel [Full author list] | Genes & Development [curation] | DOI: 10.1101/GAD.1180104
PubMed: 15082527 | hypoxia [curation] | 2004-04-01 |
| Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice | [1]Barbara Bedogni, [2]Melony S O'Neill, [3]Scott M Welford, [4]Donna M Bouley, [5]Amato J. Giaccia, [6]Nicholas C Denko, [7]Marianne Broome Powell [Full author list] | Cancer Research [curation] | DOI: 10.1158/0008-5472.CAN-03-3327
PubMed: 15059911 | | 2004-04-01 |
| Dead cells don't form tumors: HIF-dependent cytotoxins | [1]Patrick D Sutphin, [2]Denise A Chan, [3]Amato J. Giaccia [Full author list] | Cell Cycle [curation] | PubMed: 14712081 | | 2004-02-01 |
| Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest | [1]Ester M Hammond, [2]Susannah L Green, [3]Amato J. Giaccia [Full author list] | Mutation Research [curation] | DOI: 10.1016/J.MRFMMM.2003.08.017
PubMed: 14643437 | hypoxia [curation]; hydroxyurea [curation] | 2003-11-01 |
| Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer | [1]Quynh-Thu Le, [2]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | PubMed: 14555497 | | 2003-10-01 |
| Investigating hypoxic tumor physiology through gene expression patterns | [1]Nicholas C Denko, [2]Lucrezia A Fontana, [3]Karen M Hudson, [4]Patrick D Sutphin, [5]Soumya Raychaudhuri, [6]Russ Altman, [7]Amato J. Giaccia [Full author list] | Oncogene [curation] | DOI: 10.1038/SJ.ONC.1206703
PubMed: 12947397 | physiology [curation]; hypoxia [curation] | 2003-09-01 |
| HIF-alpha, a gender independent transcription factor | [1]Quynh-Thu Le, [2]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | PubMed: 12855609 | | 2003-07-01 |
| ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation | [1]Ester M Hammond, [2]Mary Jo Dorie, [3]Amato J. Giaccia [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M212360200
PubMed: 12519769 | hypoxia [curation]; phosphorylation [curation] | 2003-01-07 |
| Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas | [1]Quynh-Thu Le, [2]Patrick D Sutphin, [3]Soumya Raychaudhuri, [4]Sheue Ching T Yu, [5]David J Terris, [6]Ho Sheng Lin, [7]Bert Lum, [8]Harlan A Pinto, [9]Albert C Koong, [10]Amato J. Giaccia [Full author list] | Clinical Cancer Research [curation] | PubMed: 12538452 | | 2003-01-01 |
| Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin | [1]Christine C Hudson, [2]Mei Liu, [3]Gary G. Chiang, [4]Diane M Otterness, [5]Dawn C Loomis, [6]Fiona Kaper, [7]Amato J. Giaccia, [8]Robert T Abraham [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.22.20.7004-7014.2002
PubMed: 12242281 | cell biology [curation]; sirolimus [curation]; hypoxia [curation] | 2002-10-01 |
| Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha | [1]Denise A Chan, [2]Patrick D Sutphin, [3]Nicholas C Denko, [4]Amato J. Giaccia [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M206922200
PubMed: 12186875 | hypoxia [curation] | 2002-08-16 |
| Antiangiogenic therapy and p53. | [1]Ester M Hammond, [2]Amato J. Giaccia [Full author list] | Science [curation] | DOI: 10.1126/SCIENCE.297.5581.471A
PubMed: 12142499 | angiogenesis inhibitor [curation] | 2002-07-01 |
| Effects of perillyl alcohol on melanoma in the TPras mouse model | [1]Maria Lluria-Prevatt, [2]Jeanne Morreale, [3]Jacie Gregus, [4]David S Alberts, [5]Fiona Kaper, [6]Amato J. Giaccia, [7]Marianne Broome Powell [Full author list] | Cancer Epidemiology, Biomarkers & Prevention [curation] | PubMed: 12050099 | | 2002-06-01 |
| Hypoxia links ATR and p53 through replication arrest | [1]Ester M Hammond, [2]Nicholas C Denko, [3]Mary Jo Dorie, [4]Robert T Abraham, [5]Amato J. Giaccia [Full author list] | Molecular and Cellular Biology [curation] | DOI: 10.1128/MCB.22.6.1834-1843.2002
PubMed: 11865061 | hypoxia [curation] | 2002-03-01 |
| Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy | [1]Toru Shibata, [2]Amato J. Giaccia, [3]J Martin Brown [Full author list] | Neoplasia [curation] | DOI: 10.1038/SJ.NEO.7900189
PubMed: 11922390 | hypoxia [curation]; gene therapy [curation] | 2002-01-01 |