| Title | Authors (identified) | Published In | Identifier(s) | Topic | Published Date |
|---|
| Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced lipotoxicity in pancreatic islets | [1]Eloisa Aparecida Vilas-Boas, [2]Lisa Nalbach, [3]Emmanuel Ampofo, [4]Camila Ferraz Lucena, [5]Léa Naudet, [6]Fernanda Ortis, [7]Angelo Rafael Carpinelli, [8]Bruce Morgan, [9]Leticia Prates Roma [Full author list] | Free Radical Biology and Medicine [curation] | DOI: 10.1016/J.FREERADBIOMED.2020.11.023
PubMed: 33249137 | | 2020-11-26 |
| The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes. | [1]Kira Meyerovich, [2]Fernanda Ortis, [3]Alessandra K. Cardozo [Full author list] | Journal of Molecular Endocrinology [curation] | DOI: 10.1530/JME-16-0183
PubMed: 29728424 | NF-κB [curation] | 2018-05-04 |
| Prolactin protects against cytokine-induced beta cell death by NFkB and JNK inhibition. | [1]Tarlliza Romanna Nardelli, [2]Emerielle Cristina Vanzela, [3]Keli Cristina Benedicto, [4]Flora Brozzi, [5]André Fujita, [6]Alessandra K. Cardozo, [7]Décio Eizirik, [8]Antonio Carlos Boschero, [9]Fernanda Ortis [Full author list] | Journal of Molecular Endocrinology [curation] | DOI: 10.1530/JME-16-0257
PubMed: 29632026 | | 2018-04-09 |
| Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition | [1]Tarlliza Romanna Nardelli, [2]Keli C. Benedicto, [3]Flora Brozzi, [4]André Fujita, [5]Alessandra Kupper Cardozo, [6]Decio L Eizirik, [7]Antonio C Boschero, [8]Fernanda Ortis, [9]Emerielle C. Vanzela [Full author list] | Journal of Molecular Endocrinology [curation] | DOI: 10.1530/JME-16-0257
| diabetes [curation]; Prolactin [curation]; cell death [curation] | 2018-01-01 |
| Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation | [2]Fernanda Ortis, [3]Florent Allagnat, [4]Alessandra K. Cardozo [Full author list] | Journal of Molecular Endocrinology [curation] | DOI: 10.1530/JME-15-0306
PubMed: 27067637 | endoplasmic reticulum [curation]; inflammation [curation] | 2016-07-01 |
| A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes | [1]Makiko Fukaya, [2]Caroline Brorsson, [3]Kira Meyerovich, [4]Leen Catrysse, [5]Diane Delaroche, [6]Emerielle C Vanzela, [7]Fernanda Ortis, [8]Rudi Beyaert, [9]Lotte B Nielsen, [10]Marie L Andersen, [11]Henrik B Mortensen, [12]Flemming Pociot, [13]Geert van Loo, [14]Joachim Størling, [15]Alessandra K. Cardozo [Full author list] | Molecular Endocrinology [curation] | DOI: 10.1210/ME.2015-1176
PubMed: 26652732 | type-1 diabetes [curation] | 2015-12-10 |
| The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro | [1]Kira Meyerovich, [2]Makiko Fukaya, [3]Letícia F Terra, [4]Fernanda Ortis, [5]Decio L Eizirik, [6]Alessandra K. Cardozo [Full author list] | Diabetologia [curation] | DOI: 10.1007/S00125-015-3817-Z
PubMed: 26634571 | NF-κB [curation]; cell death [curation] | 2015-12-03 |
| Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling | [1]André O P Protzek, [2]José M Costa-Júnior, [3]Luiz F Rezende, [4]Gustavo J Santos, [5]Tiago Gomes Araújo, [6]Jean F Vettorazzi, [7]Fernanda Ortis, [8]Everardo M Carneiro, [9]Alex Rafacho, [10]Antonio C Boschero [Full author list] | International journal of endocrinology [curation] | DOI: 10.1155/2014/983453
PubMed: 25313308 | | 2014-09-17 |
| JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway | [1]D A Cunha, [2]Esteban N. Gurzov, [3]N Naamane, [4]Fernanda Ortis, [5]A K Cardozo, [6]Marco Bugliani, [7]Piero Marchetti, [8]D L Eizirik, [9]Miriam Cnop [Full author list] | Cell Death & Differentiation [curation] | DOI: 10.1038/CDD.2014.53
PubMed: 24786832 | | 2014-05-02 |
| Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII. | [1]Gustavo Jorge Dos Santos, [2]Sandra M Ferreira, [3]Fernanda Ortis, [4]Luiz Fernando Rezende, [5]Chengyang Li, [6]Ali Naji, [7]Everardo Magalhães Carneiro, [8]Klaus H. Kaestner, [9]Antonio Carlos Boschero [Full author list] | Molecular Metabolism [curation] | DOI: 10.1016/J.MOLMET.2014.03.011
PubMed: 24944908 | | 2014-04-15 |
| The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines | [1]Décio L Eizirik, [2]Michael Sammeth, [3]Thomas Bouckenooghe, [4]Guy Bottu, [5]Giorgia Sisino, [6]Mariana Igoillo-Esteve, [7]Fernanda Ortis, [8]Izortze Santin, [9]Maikel L Colli, [10]Jenny Barthson, [11]Luc Bouwens, [12]Linda Hughes, [13]Lorna Gregory, [14]Gerton Lunter, [15]Lorella Marselli, [16]Piero Marchetti, [17]Mark McCarthy, [18]Miriam Cnop [Full author list] | PLOS Genetics [curation] | DOI: 10.1371/JOURNAL.PGEN.1002552
PubMed: 22412385 | type-1 diabetes [curation]; transcriptome [curation]; RNA sequencing [curation] | 2012-03-08 |
| Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells | [1]Fernanda Ortis, [2]M Miani, [3]M L Colli, [4]D A Cunha, [5]E N Gurzov, [6]Florent Allagnat, [7]A Chariot, [8]D L Eizirik [Full author list] | FEBS Letters [curation] | DOI: 10.1016/J.FEBSLET.2012.02.021
PubMed: 22569251 | NF-κB [curation]; TNF [curation] | 2012-02-22 |
| Erratum to: Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes | [1]M. Igoillo-Esteve, [2]Lorella Marselli, [3]D. A. Cunha, [4]L. Ladrière, [5]Fernanda Ortis, [6]F. A. Grieco, [7]Francesco Dotta, [8]G. C. Weir, [9]Piero Marchetti, [10]D. L. Eizirik, [11]Miriam Cnop [Full author list] | Diabetologia [curation] | DOI: 10.1007/S00125-011-2389-9
| type 2 diabetes [curation] | 2011-12-15 |
| Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation | [1]Esteban N. Gurzov, [2]J Barthson, [3]I Marhfour, [4]Fernanda Ortis, [5]N Naamane, [6]Mariana Igoillo-Esteve, [7]C Gysemans, [8]Chantal Mathieu, [9]S Kitajima, [10]Piero Marchetti, [11]T F Ørntoft, [12]L Bakiri, [13]Erwin F. Wagner, [14]D L Eizirik [Full author list] | Oncogene [curation] | DOI: 10.1038/ONC.2011.353
PubMed: 21841823 | inflammation [curation] | 2011-08-15 |
| Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis | [1]Lukas Adrian Berchtold, [2]Zenia Marian Størling, [3]Fernanda Ortis, [4]Kasper Lage, [5]Claus Bang-Berthelsen, [6]Regine Bergholdt, [7]Jacob Hald, [8]Caroline Brorsson, [9]Decio Laks Eizirik, [10]Flemming Pociot, [11]Søren Brunak, [12]Joachim Størling [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [curation] | DOI: 10.1073/PNAS.1104384108
PubMed: 21705657 | type-1 diabetes [curation] | 2011-06-24 |
| STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation | [1]Fabrice Moore, [2]Najib Naamane, [3]Maikel L. Colli, [4]Thomas Bouckenooghe, [5]Fernanda Ortis, [6]Esteban N. Gurzov, [7]Mariana Igoillo-Esteve, [8]Chantal Mathieu, [9]Gianluca Bontempi, [10]Thomas Thykjaer, [11]Torben F. Ørntoft, [12]Decio L. Eizirik [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M110.162131
PubMed: 20980260 | inflammation [curation]; apoptotic process [curation] | 2011-01-14 |
| p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress | [1]Esteban N. Gurzov, [2]Carla M. Germano, [3]Daniel A. Cunha, [4]Fernanda Ortis, [5]Jean-Marie Vanderwinden, [6]Piero Marchetti, [7]Lin Zhang, [8]Decio L. Eizirik [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M110.122374
PubMed: 20421300 | endoplasmic reticulum [curation]; apoptotic process [curation] | 2010-06-25 |
| Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach | [1]Thomas Bouckenooghe, [2]Daisy Flamez, [3]Fernanda Ortis, [4]Serge Goldman, [5]Decio L Eizirik [Full author list] | Current Pharmaceutical Design [curation] | DOI: 10.2174/138161210791164117
PubMed: 20146665 | | 2010-05-01 |
| Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes | [1]Mariana Igoillo-Esteve, [2]Lorella Marselli, [3]D A Cunha, [4]L Ladrière, [5]Fernanda Ortis, [6]F A Grieco, [7]Francesco Dotta, [8]G C Weir, [9]Piero Marchetti, [10]D L Eizirik, [11]Miriam Cnop [Full author list] | Diabetologia [curation] | DOI: 10.1007/S00125-010-1707-Y
PubMed: 20369226 | inflammation [curation]; type 2 diabetes [curation] | 2010-04-06 |
| Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis | [1]Florent Allagnat, [2]F Christulia, [3]Fernanda Ortis, [4]P Pirot, [5]Stephan Lortz, [6]S Lenzen, [7]D L Eizirik, [8]A K Cardozo [Full author list] | Diabetologia [curation] | DOI: 10.1007/S00125-010-1699-7
PubMed: 20349222 | | 2010-03-29 |
| MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. | [1]Maikel L Colli, [2]Fabrice Moore, [3]Esteban N. Gurzov, [4]Fernanda Ortis, [5]Decio L Eizirik [Full author list] | Human Molecular Genetics [curation] | DOI: 10.1093/HMG/DDP474
PubMed: 19825843 | type-1 diabetes [curation] | 2010-01-01 |
| Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells | [1]Fernanda Ortis, [2]Najib Naamane, [3]Daisy Flamez, [4]Laurence Ladrière, [5]Fabrice Moore, [6]Daniel A Cunha, [7]Maikel L Colli, [8]Thomas Thykjaer, [9]Kasper Thorsen, [10]Torben F Orntoft, [11]Decio L Eizirik [Full author list] | Diabetes [curation] | DOI: 10.2337/DB09-1159
PubMed: 19934004 | interleukins [curation]; alternative mRNA splicing, via spliceosome [curation] | 2009-11-23 |
| Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. | [1]Daniel A Cunha, [2]Laurence Ladrière, [3]Fernanda Ortis, [4]Mariana Igoillo-Esteve, [5]Esteban N. Gurzov, [6]Roberto Lupi, [7]Piero Marchetti, [8]Décio L Eizirik, [9]Miriam Cnop [Full author list] | Diabetes [curation] | DOI: 10.2337/DB09-0685
PubMed: 19720788 | endoplasmic reticulum [curation] | 2009-08-31 |
| Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis | [1]Esteban N. Gurzov, [2]Fernanda Ortis, [3]D A Cunha, [4]G Gosset, [5]M Li, [6]A K Cardozo, [7]D L Eizirik [Full author list] | Cell Death & Differentiation [curation] | DOI: 10.1038/CDD.2009.99
PubMed: 19629134 | apoptotic process [curation] | 2009-07-24 |
| The role of inflammation in insulitis and beta-cell loss in type 1 diabetes | [1]Décio L Eizirik, [2]Maikel L Colli, [3]Fernanda Ortis [Full author list] | Nature Reviews Endocrinology [curation] | DOI: 10.1038/NRENDO.2009.21
PubMed: 19352320 | inflammation [curation]; type-1 diabetes [curation]; insulitis [curation] | 2009-04-01 |
| JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells | [1]Esteban N. Gurzov, [2]Fernanda Ortis, [3]Latifa Bakiri, [4]Erwin F. Wagner, [5]Decio L Eizirik [Full author list] | PLOS One [curation] | DOI: 10.1371/JOURNAL.PONE.0003030
PubMed: 18716665 | | 2008-08-21 |
| Initiation and execution of lipotoxic ER stress in pancreatic beta-cells | [1]Daniel A Cunha, [2]Paul Hekerman, [3]Laurence Ladrière, [4]Angie Bazarra-Castro, [5]Fernanda Ortis, [6]Marion C Wakeham, [7]Fabrice Moore, [8]Joanne Rasschaert, [9]Alessandra K. Cardozo, [10]Elisa A. Bellomo, [11]Lutgart Overbergh, [12]Chantal Mathieu, [13]Roberto Lupi, [14]Tsonwin Hai, [15]Andre Herchuelz, [16]Piero Marchetti, [17]Guy A. Rutter, [18]Décio L Eizirik, [19]Miriam Cnop [Full author list] | Journal of Cell Science [curation] | DOI: 10.1242/JCS.026062
PubMed: 18559892 | | 2008-06-17 |
| Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes | [1]Decio L Eizirik, [2]Fabrice Moore, [3]Daisy Flamez, [4]Fernanda Ortis [Full author list] | Biochemical Society Transactions [curation] | DOI: 10.1042/BST0360321
PubMed: 18481950 | type-1 diabetes [curation]; cell death [curation] | 2008-06-01 |
| Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells | [1]Fernanda Ortis, [2]P Pirot, [3]N Naamane, [4]A Y Kreins, [5]J Rasschaert, [6]F Moore, [7]E Théâtre, [8]C Verhaeghe, [9]Nils Erik Magnusson, [10]A Chariot, [11]T F Orntoft, [12]D L Eizirik [Full author list] | Diabetologia [curation] | DOI: 10.1007/S00125-008-0999-7
PubMed: 18463842 | apoptotic process [curation] | 2008-05-08 |
| Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue | [1]Amir J Guri, [2]Raquel Hontecillas, [3]Gerardo Ferrer, [4]Oriol Casagran, [5]Umesh Wankhade, [6]Alexis M Noble, [7]Decio L Eizirik, [8]Fernanda Ortis, [9]Miriam Cnop, [10]Dongmin Liu, [11]Hongwei Si, [12]Josep Bassaganya-Riera [Full author list] | Journal of Nutritional Biochemistry [curation] | DOI: 10.1016/J.JNUTBIO.2007.02.010
PubMed: 17618105 | macrophage [curation] | 2007-07-06 |
| Cell-permeable peptides induce dose- and length-dependent cytotoxic effects | [1]Alessandra K. Cardozo, [2]Valérie Buchillier, [3]Marc Mathieu, [4]Jianhua Chen, [5]Fernanda Ortis, [6]Laurence Ladrière, [7]Nathalie Allaman-Pillet, [8]Olivier Poirot, [9]Stephan Kellenberger, [10]Jacques S Beckmann, [11]Decio L Eizirik, [12]Christophe Bonny, [13]Fabienne Maurer [Full author list] | Biochimica et Biophysica Acta [curation] | DOI: 10.1016/J.BBAMEM.2007.06.003
PubMed: 17626783 | cytotoxicity [curation] | 2007-06-14 |
| Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells | [1]Pierre Pirot, [2]Fernanda Ortis, [3]Miriam Cnop, [4]Yanjun Ma, [5]Linda M Hendershot, [6]Décio L Eizirik, [7]Alessandra K. Cardozo [Full author list] | Diabetes [curation] | DOI: 10.2337/DB06-1253
PubMed: 17395747 | endoplasmic reticulum [curation]; preproinsulin [curation] | 2007-04-01 |
| Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis | [1]Miriam Cnop, [2]Laurence Ladriere, [3]Paul Hekerman, [4]Fernanda Ortis, [5]Alessandra K. Cardozo, [6]Zeynep Dogusan, [7]Daisy Flamez, [8]Michael Boyce, [9]Junying Yuan, [10]Decio L. Eizirik [Full author list] | Journal of Biological Chemistry [curation] | DOI: 10.1074/JBC.M607627200
PubMed: 17158450 | fatty acid [curation]; endoplasmic reticulum [curation]; apoptotic process [curation] | 2007-02-09 |
| Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation | [1]Fernanda Ortis, [2]Alessandra K. Cardozo, [3]Daisy Crispim, [4]Joachim Størling, [5]Thomas Mandrup-Poulsen, [6]Decio L Eizirik [Full author list] | Molecular Endocrinology [curation] | DOI: 10.1210/ME.2005-0268
PubMed: 16556731 | | 2006-03-23 |
| Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells | [1]Alessandra K. Cardozo, [2]Fernanda Ortis, [3]Joachim Storling, [4]Ying-Mei Feng, [5]Joanne Rasschaert, [6]Morten Tonnesen, [7]Françoise Van Eylen, [8]Thomas Mandrup-Poulsen, [9]André Herchuelz, [10]Décio L Eizirik [Full author list] | Diabetes [curation] | DOI: 10.2337/DIABETES.54.2.452
PubMed: 15677503 | endoplasmic reticulum [curation] | 2005-02-01 |
| 40th EASD Annual Meeting of the European Association for the Study of Diabetes | [1]M Veitenhansl, ..., [2]K Stegner, [3]F-X Hierl, [4]C Dieterle, [5]H Feldmeier, [6]B Gutt, [7]R Landgraf, [8]A P Garrow, [9]L Vileikyte, [10]A Findlow, ..., [523]N Billestrup, [524]A K Cardozo, [525]Fernanda Ortis, [526]Y-M Feng, [527]J Rasschaert, ... [Full author list] | Diabetologia [curation] | DOI: 10.1007/BF03375463
PubMed: 27770180 | diabetes [curation] | 2004-08-01 |
| Use of pEX and pGEX bacterial heterologous protein expression systems for recombinant oncoprotein production and antisera generation | [1]C Pompéia, [2]Fernanda Ortis, [3]M C Armelin [Full author list] | Biotechnology and Applied Biochemistry [curation] | PubMed: 9198274 | | 1997-06-01 |
| Immunopurification of polyclonal antibodies to recombinant proteins of the same gene family | [1]C Pompéia, [2]Fernanda Ortis, [3]M C Armelin [Full author list] | BioTechniques [curation] | DOI: 10.2144/96216BM03
PubMed: 8969818 | | 1996-12-01 |