| Title | Authors (identified) | Published In | Identifier(s) | Topic | Published Date |
|---|
| Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers | [1]C Glenn Begley, [2]Mark Ashton, [3]Jonathan B Baell, [4]Michael Bettess, [5]Michael P. Brown, [6]Brett Carter, [7]William N. Charman, [8]Christopher Davis, [9]Simon Fisher, [10]Ian Frazer, ... [Full author list] | Science Translational Medicine [curation] | DOI: 10.1126/SCITRANSLMED.ABD5524
| | 2021-09-22 |
| Nuisance compounds in cellular assays | [1]Jayme L Dahlin, [2]Douglas S Auld, [3]Ina Rothenaigner, [4]Steve Haney, [5]Jonathan Z Sexton, [6]Willem Nissink, [7]Jarrod Walsh, [8]Jonathan A. Lee, [9]John M. Strelow, [10]Francis S Willard, [11]Lori Ferrins, [12]Jonathan B Baell, [13]Michael A Walters, [14]Bruce Hua, [15]Kamyar Hadian, [16]Bridget K Wagner [Full author list] | Cell chemical biology [curation] | DOI: 10.1016/J.CHEMBIOL.2021.01.021
| | 2021-03-01 |
| 1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity | [1]Sarah Preston, [2]José Francisco García-Bustos, [3]Liam G Hall, [4]Sheree D Martin, [5]Thuy G Le, [6]Abhijit Kundu, [7]Atanu Ghoshal, [8]Nghi H Nguyen, [9]Yaqing Jiao, [10]Banfeng Ruan, [11]Lian Xue, [12]Fei Huang, [13]Bill C H Chang, [14]Sean L McGee, [15]Timothy N C Wells, [16]Michael J Palmer, [17]Abdul Jabbar, [18]Robin B Gasser, [19]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.0C01793
PubMed: 33352050 | | 2020-12-22 |
| I2-Promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones: facile and efficient synthesis of 1,4-dihydropyridazines and pyridazines | [1]Jiajun Feng, [2]Tiantong He, [3]Yuxing Xie, [4]Yang Yu, [5]Jonathan B Baell, [6]Fei Huang [Full author list] | Organic and Biomolecular Chemistry [curation] | DOI: 10.1039/D0OB01958E
PubMed: 33179698 | | 2020-11-12 |
| Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents | [1]Daniel L. Priebbenow, [2]David J Leaver, [3]Nghi Nguyen, [4]Benjamin Cleary, [5]H Rachel Lagiakos, [6]Julie Sanchez, [7]Lian Xue, [8]Fei Huang, [9]Yuxin Sun, [10]Prashant Mujumdar, ..., [31]Anne K Voss, [32]Tim Thomas, [33]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.9B02071
PubMed: 32118427 | | 2020-03-19 |
| Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors | [1]Yiyue Xie, [2]Padmaja Tummala, [3]Aaron J Oakley, [4]Girdhar S Deora, [5]Yuji Nakano, [6]Melissa Rooke, [7]Matthew E Cuellar, [8]Jessica M Strasser, [9]Jayme L Dahlin, [10]Michael A Walters, [11]Marco G Casarotto, [12]Philip G Board, [13]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.9B01391
PubMed: 32105470 | | 2020-03-16 |
| Action plan for hit identification (APHID): KAT6A as a case study | [1]Xiangyan Yi, [2]Lian Xue, [3]Tim Thomas, [4]Jonathan B Baell [Full author list] | Future Medicinal Chemistry [curation] | DOI: 10.4155/FMC-2019-0212
PubMed: 32064938 | | 2020-02-17 |
| Crystal structure of the M5 muscarinic acetylcholine receptor | [1]Ziva Vuckovic, [2]Patrick R Gentry, [3]Alice E Berizzi, [4]Kunio Hirata, [5]Swapna Varghese, [6]Geoff Thompson, [7]Emma T van der Westhuizen, [8]Wessel A C Burger, [9]Raphael Rahmani, [10]Celine Valant, [11]Christopher J Langmead, [12]Craig W. Lindsley, [13]Jonathan B Baell, [14]Andrew B Tobin, [15]Patrick M. Sexton, [16]Arthur Christopoulos, [17]David M Thal [Full author list] | Proceedings of the National Academy of Sciences of the United States of America [curation] | DOI: 10.1073/PNAS.1914446116
PubMed: 31772027 | | 2019-11-26 |
| Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A | [1]David J Leaver, [2]Benjamin Cleary, [3]Nghi Nguyen, [4]Daniel L. Priebbenow, [5]H Rachel Lagiakos, [6]Julie Sanchez, [7]Lian Xue, [8]Fei Huang, [9]Yuxin Sun, [10]Prashant Mujumdar, ..., [28]Michael W Parker, [29]Tim Thomas, [30]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.9B00665
PubMed: 31256587 | | 2019-07-17 |
| Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists | [1]Girdhar S Deora, [2]Cheng Xue Qin, [3]Elizabeth A Vecchio, [4]Aaron J Debono, [5]Daniel L. Priebbenow, [6]Ryan M Brady, [7]Julia Beveridge, [8]Silvia C Teguh, [9]Minh Deo, [10]Lauren T May, [11]Guy Krippner, [12]Rebecca H Ritchie, [13]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.8B01912
PubMed: 31038950 | | 2019-05-13 |
| Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity | [1]Thuy G Le, [2]Abhijit Kundu, [3]Atanu Ghoshal, [4]Nghi H Nguyen, [5]Sarah Preston, [6]Yaqing Jiao, [7]Banfeng Ruan, [8]Lian Xue, [9]Fei Huang, [10]Jennifer Keiser, [11]Andreas Hofmann, [12]Bill C H Chang, [13]Jose Garcia-Bustos, [14]Timothy N C Wells, [15]Michael J Palmer, [16]Abdul Jabbar, [17]Robin B. Gasser, [18]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.8B01790
PubMed: 30875218 | | 2019-03-28 |
| 3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity | [1]Lian Xue, [2]Da-Hua Shi, [3]Jitendra R Harjani, [4]Fei Huang, [5]Julia G Beveridge, [6]Tamir Dingjan, [7]Kung Ban, [8]Sarah Diab, [9]Sandra Duffy, [10]Leonardo Lucantoni, ..., [28]Michael D. Edstein, [29]Vicky M. Avery, [30]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.8B01799
PubMed: 30715882 | | 2019-03-05 |
| Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development | [1]Thuy G Le, [2]Abhijit Kundu, [3]Atanu Ghoshal, [4]Nghi H Nguyen, [5]Sarah Preston, [6]Yaqing Jiao, [7]Banfeng Ruan, [8]Lian Xue, [9]Fei Huang, [10]Jennifer Keiser, [11]Andreas Hofmann, [12]Bill C H Chang, [13]Jose Garcia-Bustos, [14]Timothy N C Wells, [15]Michael J Palmer, [16]Abdul Jabbar, [17]Robin B. Gasser, [18]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.8B01789
PubMed: 30571110 | Haemonchus contortus [curation] | 2019-01-07 |
| Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm | [1]Thuy G Le, [2]Abhijit Kundu, [3]Atanu Ghoshal, [4]Nghi H Nguyen, [5]Sarah Preston, [6]Yaqing Jiao, [7]Banfeng Ruan, [8]Lian Xue, [9]Fei Huang, [10]Jennifer Keiser, [11]Andreas Hofmann, [12]Bill C H Chang, [13]Jose Garcia-Bustos, [14]Abdul Jabbar, [15]Timothy N C Wells, [16]Michael J Palmer, [17]Robin B. Gasser, [18]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.8B01544
PubMed: 30403349 | | 2018-11-29 |
| Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example | [1]Yiyue Xie, [2]Jayme L Dahlin, [3]Aaron J. Oakley, [4]Marco G Casarotto, [5]Philip G Board, [6]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.8B00318
PubMed: 29652143 | | 2018-05-10 |
| Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury' | [1]Cheng Xue Qin, [2]Lauren T May, [3]Patrick M. Sexton, [4]Aaron J DeBono, [5]Jonathan B Baell, [6]Arthur Christopoulos, [7]Rebecca H. Ritchie [Full author list] | Nature Communications [curation] | DOI: 10.1038/S41467-017-02656-0
PubMed: 29416022 | reperfusion injury [curation] | 2018-02-07 |
| Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations | [1]Jonathan B Baell, [1-Q87721461]Jonathan B Baell, [2]J Willem M Nissink, [2-Q53346590]Willem Nissink [Full author list] | ACS Chemical Biology [curation] | DOI: 10.1021/ACSCHEMBIO.7B00903
PubMed: 29202222 | biomedical investigative technique [curation] | 2018-01-19 |
| GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity | [1]Deepthi Menon, [2]Ashlee Innes, [3]Aaron J. Oakley, [4]Jane E. Dahlstrom, [5]Lora M Jensen, [6]Anne Brüstle, [7]Padmaja Tummala, [8]Melissa Rooke, [9]Marco G Casarotto, [10]Jonathan B Baell, [11]Nghi Nguyen, [12]Yiyue Xie, [13]Matthew Cuellar, [14]Jessica Strasser, [15]Jayme L Dahlin, [16]Michael A Walters, [17]Gaétan Burgio, [18]Luke A. J. O'Neill, [19]Philip G. Board [Full author list] | Scientific Reports [curation] | DOI: 10.1038/S41598-017-17861-6
PubMed: 29259211 | | 2017-12-19 |
| Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors | [1]Jayme L Dahlin, [2]Kathryn M Nelson, [3]Jessica Strasser, [4]Dalia Barsyte-Lovejoy, [5]Magdalena M. Szewczyk, [6]Shawna Organ, [7]Matthew Cuellar, [8]Gurpreet Singh, [9]Jonathan H Shrimp, [10]Nghi Nguyen, [11]Jordan L Meier, [12]Cheryl Arrowsmith, [13]Peter J. Brown, [14]Jonathan B Baell, [15]Michael A Walters [Full author list] | Nature Communications [curation] | DOI: 10.1038/S41467-017-01657-3
PubMed: 29142305 | | 2017-11-15 |
| Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain | [1]Sarah Preston, [2]Pasi K. Korhonen, [3]Laurent Mouchiroud, [4]Matteo Cornaglia, [5]Sean L McGee, [6]Neil D. Young, [7]Rohan A. Davis, [8]Simon Crawford, [9]Cameron Nowell, [10]Brendan R Ansell, [11]Gillian M Fisher, [12]Katherine T Andrews, [13]Bill H. Chang, [14]Martin A M Gijs, [15]Paul W. Sternberg, [16]Johan Auwerx, [17]Jonathan B Baell, [18]Andreas Hofmann, [19]Abdul Jabbar, [20]Robin B. Gasser [Full author list] | FASEB Journal [curation] | DOI: 10.1096/FJ.201700288R
PubMed: 28687609 | | 2017-07-07 |
| Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity | [1]Paul R Gilson, [2]Cyrus Tan, [3]Kate E Jarman, [4]Kym N Lowes, [5]Joan M Curtis, [6]William Nguyen, [7]Adrian E Di Rago, [8]Hayley E Bullen, [9]Boris Prinz, [10]Sandra Duffy, [11]Jonathan B Baell, [12]Craig Hutton, [13]Helene Jousset Subroux, [14]Brendan Crabb, [15]Vicky M. Avery, [16]Alan Frederick Cowman, [17]Brad E Sleebs [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.6B01673
PubMed: 28080063 | antimalarial [curation] | 2017-01-12 |
| Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles | [1]Alice Motion, [2]Paul M. Ylioja, [3]Murray N. Robertson, [4]Yevgeniya Antonova-Koch, [45-Q51897364]Peter Turner, [5]Vicky M. Avery, [6]Jonathan B Baell, [7]Harikrishna Batchu, [8]Sanjay Batra, [9]Jeremy Burrows, [10]Soumya Bhattacharyya, ... [Full author list] | ACS Central Science [curation] | DOI: 10.1021/ACSCENTSCI.6B00086
PubMed: 27800551 | antimalarial [curation]; open-source software [curation]; drug discovery [curation]; open-source drug discovery [curation] | 2016-09-14 |
| Histone acetyltransferase inhibitors: where art thou? | [1]Jonathan B Baell, [1-Q87721461]Jonathan B Baell, [2]Wenjun Miao, [2-Q85197772]Wenjun Miao [Full author list] | Future Medicinal Chemistry [curation] | DOI: 10.4155/FMC-2016-0151
PubMed: 27557114 | | 2016-08-24 |
| Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides | [1]Stephanie Russell, [2]Raphaël Rahmani, [3]Amy J Jones, [4]Harriet L Newson, [5]Kevin Neilde, [6]Ignacio Cotillo, [7]Marzieh Rahmani Khajouei, [8]Lori Ferrins, [9]Sana Qureishi, [10]Nghi Nguyen, ..., [23]Albane Kessler, [24]Vicky M. Avery, [25]Jonathan B Baell, [26]Matthew J Piggott [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/ACS.JMEDCHEM.6B00442
PubMed: 27548560 | | 2016-08-22 |
| Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus | [1]Sarah Preston, [2]Junjie Luo, [3]Yuezhou Zhang, [4]Abdul Jabbar, [5]Simon Crawford, [6]Jonathan B Baell, [7]Andreas Hofmann, [8]Min Hu, [9]Hai-Bing Zhou, [10]Robin B. Gasser [Full author list] | Parasites and Vectors [curation] | DOI: 10.1186/S13071-016-1612-4
PubMed: 27306029 | Haemonchus contortus [curation] | 2016-06-16 |
| Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum | [1]Charisse Flerida A Pasaje, [2]Vanessa Cheung, [3]Kit Kennedy, [4]Erin E Lim, [5]Jonathan B Baell, [6]Michael Griffin, [7]Stuart A Ralph [Full author list] | Scientific Reports [curation] | DOI: 10.1038/SREP27531
PubMed: 27277538 | Plasmodium falciparum [curation]; tryptophan--tRNA ligase [curation]; tryptophan--tRNA ligase [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation]; tryptophan--tRNA ligase, putative [curation] | 2016-06-09 |
| Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction | [1]Beow Keat Yap, [2]Jitendra R Harjani, [3]Eleanor W W Leung, [4]Sandra E Nicholson, [5]Martin J. Scanlon, [6]David K. Chalmers, [7]Philip E. Thompson, [8]Jonathan B Baell, [9]Raymond Norton [Full author list] | FEBS Letters [curation] | DOI: 10.1002/1873-3468.12115
PubMed: 26921848 | | 2016-02-27 |
| Erratum: Corrigendum: The promise and peril of chemical probes | [1]Cheryl Arrowsmith, [2]James E Audia, [3]Christopher Austin, [4]Jonathan B Baell, [5]Jonathan Bennett, [6]Julian Blagg, [7]Chas Bountra, [8]Paul E Brennan, [9]Peter J Brown, [10]Mark E Bunnage, ... [Full author list] | Nature Chemical Biology [curation] | DOI: 10.1038/NCHEMBIO1115-887C
PubMed: 26485080 | The promise and peril of chemical probes [curation] | 2015-11-01 |
| The promise and peril of chemical probes | [1]Cheryl Arrowsmith, [2]James E Audia, [3]Christopher Austin, [4]Jonathan B Baell, [5]Jonathan Bennett, [6]Julian Blagg, [7]Chas Bountra, [8]Paul E. Brennan, [9]Peter J. Brown, [10]Mark E Bunnage, ... [Full author list] | Nature Chemical Biology [curation] | DOI: 10.1038/NCHEMBIO.1867
PubMed: 26196764 | | 2015-07-01 |
| Low cost whole-organism screening of compounds for anthelmintic activity | [1]Sarah Preston, [2]Abdul Jabbar, [3]Cameron Nowell, [4]Anja Joachim, [5]Bärbel Ruttkowski, [6]Jonathan B Baell, [7]Tony Cardno, [8]Pasi K. Korhonen, [9]David Piedrafita, [10]Brendan R Ansell, [11]Aaron R Jex, [12]Andreas Hofmann, [13]Robin B. Gasser [Full author list] | International Journal for Parasitology [curation] | DOI: 10.1016/J.IJPARA.2015.01.007
PubMed: 25746136 | | 2015-03-05 |
| Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function | [1]Mark A Baker, [2]Anita Weinberg, [3]Louise Hetherington, [4]Ana-Izabel Villaverde, [5]Tony Velkov, [6]Jonathan B Baell, [7]Christopher Gordon [Full author list] | Biology of Reproduction [curation] | DOI: 10.1095/BIOLREPROD.114.126680
PubMed: 25673561 | reactive oxygen species [curation] | 2015-02-11 |
| Screening-based translation of public research encounters painful problems | [1]Jonathan B Baell, [1-Q87721461]Jonathan B Baell [Full author list] | ACS Medicinal Chemistry Letters [curation] | DOI: 10.1021/ACSMEDCHEMLETT.5B00032
PubMed: 25941544 | | 2015-02-09 |
| A practical Java tool for small-molecule compound appraisal | [1]Parisa Amani, [2]Todd Sneyd, [3]Sarah Preston, [4]Neil D. Young, [5]Lyndel Mason, [6]Ulla-Maja Bailey, [7]Jonathan B Baell, [8]David Camp, [9]Robin B. Gasser, [10]Alain-Dominique Gorse, [11]Paul Taylor, [12]Andreas Hofmann [Full author list] | Journal of Cheminformatics [curation] | DOI: 10.1186/S13321-015-0079-1
PubMed: 26082805 | | 2015-01-01 |
| Chemistry: Chemical con artists foil drug discovery | [1]Jonathan Baell, [1-Q87721461]Jonathan B Baell, [2]Michael A Walters, [2-Q47153419]Michael A Walters [Full author list] | Nature [curation] | DOI: 10.1038/513481A
PubMed: 25254460 | chemistry [curation]; drug discovery [curation] | 2014-09-01 |
| A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research - eighteen million assays and counting | [1]Kurt Lackovic, [2]Guillaume Lessene, [3]Hendrik Falk, [4]Karl-Johan Leuchowius, [5]Jonathan B Baell, [6]Ian Street [Full author list] | Combinatorial Chemistry & High Throughput Screening [curation] | DOI: 10.2174/1386207317666140109122450
PubMed: 24409955 | | 2014-03-01 |
| Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor | [1]Brid Callaghan, [2]Sam Kosari, [3]Ruslan V Pustovit, [4]Daniela M Sartor, [5]Dorota M Ferens, [6]Kung Ban, [7]Jonathan B Baell, [8]Trung V Nguyen, [9]Leni R Rivera, [10]James A. Brock, [11]John B. Furness [Full author list] | British Journal of Pharmacology [curation] | DOI: 10.1111/BPH.12527
PubMed: 24670149 | | 2014-03-01 |
| Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs | [1]Ron Ofer Dror, [2]Hillary F Green, [3]Celine Valant, [4]David W. Borhani, [5]James R Valcourt, [6]Albert C Pan, [7]Daniel H Arlow, [8]Meritxell Canals, [9]J. Robert Lane, [10]Raphael Rahmani, [11]Jonathan B Baell, [12]Patrick M. Sexton, [13]Arthur Christopoulos, [14]David E Shaw [Full author list] | Nature [curation] | DOI: 10.1038/NATURE12595
PubMed: 24121438 | G protein-coupled receptor [curation] | 2013-10-13 |
| Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity | [1]Silvia C Teguh, [2]Nectarios Klonis, [3]Sandra Duffy, [4]Leonardo Lucantoni, [5]Vicky M. Avery, [6]Craig Hutton, [7]Jonathan B Baell, [8]Leann Tilley [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/JM400656S
PubMed: 23837878 | Plasmodium falciparum [curation]; antimalarial [curation] | 2013-07-26 |
| Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL | [1]Brad E Sleebs, [2]Wilhemus J A Kersten, [3]Sanji Kulasegaram, [4]George Nikolakopoulos, [5]Effie Hatzis, [6]Rebecca M Moss, [7]John P Parisot, [8]Hong Yang, [9]Peter E Czabotar, [10]Walter D Fairlie, ..., [18]Peter M Colman, [19]Ian P Street, [20]Jonathan B Baell, [21]Keith Watson, [22]Guillaume Lessene [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/JM400556W
PubMed: 23767404 | | 2013-06-26 |
| Ask the experts: past, present and future of the rule of five. | [1]Jonathan B Baell, [2]Miles Congreve, [3]Paul Leeson, [4]Celerino Abad-Zapatero [Full author list] | Future Medicinal Chemistry [curation] | DOI: 10.4155/FMC.13.61
PubMed: 23651089 | | 2013-05-01 |
| PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening | [1]Jonathan B Baell, [2]Lori Ferrins, [3]Hendrik Falk, [4]George Nikolakopoulos [Full author list] | Australian Journal of Chemistry [curation] | DOI: 10.1071/CH13551
| | 2013-01-01 |
| Sites of action of ghrelin receptor ligands in cardiovascular control. | [1]Brid Callaghan, [2]Billie Hunne, [3]Haruko Hirayama, [4]Daniela M Sartor, [5]Trung V Nguyen, [6]Fe C Abogadie, [7]Dorota M Ferens, [8]Peter McIntyre, [9]Kung Ban, [10]Jonathan B Baell, [11]John B. Furness, [12]James A. Brock [Full author list] | American Journal of Physiology Heart and Circulatory Physiology [curation] | DOI: 10.1152/AJPHEART.00418.2012
PubMed: 22886413 | circulatory system [curation] | 2012-08-10 |
| Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity | [1]Brad E Sleebs, [2]Peter E Czabotar, [3]Wayne J Fairbrother, [4]Walter D Fairlie, [5]John A Flygare, [6]David C Huang, [7]Wilhelmus J A Kersten, [8]Michael F. Koehler, [9]Guillaume Lessene, [10]Kym Lowes, [11]John P Parisot, [12]Brian J. Smith, [13]Morey L Smith, [14]Andrew J Souers, [15]Ian P Street, [16]Hong Yang, [17]Jonathan B Baell [Full author list] | Journal of Medicinal Chemistry [curation] | DOI: 10.1021/JM101596E
PubMed: 21366295 | B-cell lymphoma [curation]; apoptotic process [curation] | 2011-03-02 |
| 3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity | [1]Kung Ban, [2]Sandra Duffy, [3]Yelena Khakham, [4]Vicky M. Avery, [5]Andrew Hughes, [6]Oliver Montagnat, [7]Kasiram Katneni, [8]Eileen Ryan, [9]Jonathan B Baell [Full author list] | Bioorganic & Medicinal Chemistry Letters [curation] | DOI: 10.1016/J.BMCL.2010.08.065
PubMed: 20822904 | antimalarial [curation] | 2010-08-19 |
| Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines | [1]Duong Nhu, [2]Sandra Duffy, [3]Vicky M. Avery, [4]Andrew Hughes, [5]Jonathan B Baell [Full author list] | Bioorganic & Medicinal Chemistry Letters [curation] | DOI: 10.1016/J.BMCL.2010.06.036
PubMed: 20584608 | antimalarial [curation] | 2010-06-10 |
| Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity | [1]Georgina A Holloway, [2]William N. Charman, [3]Alan Fairlamb, [4]Reto Brun, [5]Marcel Kaiser, [6]Edmund Kostewicz, [7]Patrizia M Novello, [8]John P Parisot, [9]John Richardson, [10]Ian P Street, [11]Keith G Watson, [12]Jonathan B Baell [Full author list] | Antimicrobial Agents and Chemotherapy [curation] | DOI: 10.1128/AAC.01568-08
PubMed: 19364854 | | 2009-04-13 |
| Inhibition studies of sulfonamide-containing folate analogs in yeast | [1]Onisha Patel, [2]Jacqueline R. Satchell, [3]Jonathan B Baell, [4]Ross Fernley, [5]Peter Coloe, [6]Ian Macreadie [Full author list] | Microbial Drug Resistance [curation] | DOI: 10.1089/107662903765826723
PubMed: 12820798 | folic acid [curation] | 2003-01-01 |