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22 publications found

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Group #1

TitleAuthors (identified)Published InIdentifier(s)TopicPublished DateMatch?
Corrections to Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)[1]Dan Niculescu-Duvaz, [2]Catherine Gaulon, [3]Harmen P. Dijkstra, [4]Ion Niculescu-Duvaz, [5]Alfonso Zambon, [6]Delphine Ménard, [7]Bart M. J. M. Suijkerbuijk, [8]Arnaud Nourry, [9]Lawrence C. Davies, [10]Helen Manne, ..., [14]Steven Whittaker, [15]Ruth Kirk, [16]Adrian Gill, [17]Richard D. Taylor, [18]Florence I. Raynaud, ... [Full author list]Journal of Medicinal Chemistry [missing]DOI: 10.1021/JM901076G [ORCID]
2009-09-24
Novel potent BRAF inhibitors: toward 1 nM compounds through optimization of the central phenyl ring.[1]Delphine Ménard, [2]Ion Niculescu-Duvaz, [3]Harmen P Dijkstra, [4]Dan Niculescu-Duvaz, [5]Bart M J M Suijkerbuijk, [6]Alfonso Zambon, [7]Arnaud Nourry, [8]Esteban Roman, [9]Lawrence C. Davies, [10]Helen A Manne, [11]Frank Friedlos, [12]Ruth Kirk, [13]Steven Whittaker, [14]Adrian Gill, [15]Richard D Taylor, [16]Richard Marais, [17]Caroline J Springer [Full author list]Journal of Medicinal Chemistry [missing]DOI: 10.1021/JM900242C [ORCID]
PubMed: 19473026 [ORCID]
2009-07-01
Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).[1]Dan Niculescu-Duvaz, [2]Catherine Gaulon, [3]Harmen P Dijkstra, [4]Ion Niculescu-Duvaz, [5]Alfonso Zambon, [6]Delphine Ménard, [7]Bart M J M Suijkerbuijk, [8]Arnaud Nourry, [9]Lawrence C. Davies, [10]Helen Manne, ..., [14]Steven Whittaker, [15]Ruth Kirk, [16]Adrian Gill, [17]Richard D Taylor, [18]Florence Raynaud, ... [Full author list]Journal of Medicinal Chemistry [missing]DOI: 10.1021/JM801509W [ORCID]
PubMed: 19323560 [ORCID]
2009-04-01

Group #2

TitleAuthors (identified)Published InIdentifier(s)TopicPublished DateMatch?
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS[1]Christopher J. Schulze, [2]Kyle J. Seamon, [3]Yulei Zhao, [4]Yu Chi Yang, [5]Jim Cregg, [6]Dongsung Kim, [7]Aidan Tomlinson, [8]Tiffany J Choy, [9]Zhican Wang, [10]Ben Sang, ..., [32]Robert Nichols, [33]David Wildes, [34]Adrian L. Gill, [35]Jacqueline A M Smith, [36]Piro Lito [Full author list]Science [missing]DOI: 10.1126/SCIENCE.ADG9652 [ORCID]
2023-08-17
Allosteric inhibition of SHP2 stimulates anti-tumor immunity by transforming the immunosuppressive environment[1]Elsa Quintana, [2]Christopher J Schulze, [3]Darienne R Myers, [4]Tiffany J Choy, [5]Kasia Mordec, [6]David Wildes, [7]Nataliya Tobvis Shifrin, [8]Amira Belwafa, [9]Elena S Koltun, [10]Adrian L Gill, [11]Mallika Singh, [12]Stephen Kelsey, [13]Mark A Goldsmith, [14]Robert Nichols, [15]Jacqueline A M Smith [Full author list]Cancer Research [missing]DOI: 10.1158/0008-5472.CAN-19-3038 [ORCID]
PubMed: 32350067 [ORCID]
2020-04-29
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers[1]Robert J Nichols, [2]Franziska Haderk, [3]Carlos Stahlhut, [4]Christopher J Schulze, [5]Golzar Hemmati, [6]David Wildes, [7]Christos Tzitzilonis, [8]Kasia Mordec, [9]Abby Marquez, [10]Jason Romero, ..., [17]Gert Kiss, [18]Elena S Koltun, [19]Adrian L Gill, [20]Mallika Singh, [21]Mark A Goldsmith, ... [Full author list]Nature Cell Biology [missing]DOI: 10.1038/S41556-018-0169-1 [ORCID]
PubMed: 30104724 [ORCID]
2018-08-13

Misc

TitleAuthors (identified)Published InIdentifier(s)TopicPublished DateMatch?
Automated iterative Csp3–C bond formation[1]Daniel J. Blair, [2]Sriyankari Chitti, [3]Melanie Trobe, [4]David M. Kostyra, [5]Hannah M. S. Haley, [6]Richard L. Hansen, [7]Steve G. Ballmer, [8]Toby J. Woods, [9]Wesley Wang, [10]Vikram Mubayi, [11]Michael J. Schmidt, [12]Robert W. Pipal, [13]Greg. F. Morehouse, [14]Andrea M. E. Palazzolo Ray, [15]Danielle L. Gray, [16]Adrian L. Gill, [17]Martin D. Burke [Full author list]Nature [missing]DOI: 10.1038/S41586-022-04491-W [ORCID]
2022-02-08
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors[1]Maruti Naik, [2]Anandkumar Raichurkar, [3]Balachandra S Bandodkar, [4]Begur V Varun, [5]Shantika Bhat, [6]Rajesh Kalkhambkar, [7]Kannan Murugan, [8]Rani Menon, [9]Jyothi Bhat, [10]Beena Paul, ..., [16]Helen McMiken, [17]Swati Prasad, [18]Adrian Gill, [19]Bheemarao G Ugarkar, [20]Janani Venkatraman, ... [Full author list]Journal of Medicinal Chemistry [missing]DOI: 10.1021/JM5012947 [ORCID]
PubMed: 25486447 [ORCID]
tuberculosis [missing]; Mycobacterium tuberculosis [missing]2015-01-22
Using matched molecular series as a predictive tool to optimize biological activity[1]Noel O'Boyle, [2]Jonas Boström, [3]Roger Sayle, [4]Adrian Gill [Full author list]Journal of Medicinal Chemistry [missing]DOI: 10.1021/JM500022Q [ORCID]
PubMed: 24601597 [ORCID]
2014-03-14
Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion[1]Fabrizio Giordanetto, [2]Jefferson D Revell, [3]Laurent Knerr, [4]Marie Hostettler, [5]Amalia Paunovic, [6]Claire Priest, [7]Annika Janefeldt, [8]Adrian Gill [Full author list]ACS Medicinal Chemistry Letters [missing]DOI: 10.1021/ML400257H [ORCID]
PubMed: 24900623 [ORCID]
glucose [missing]; glycobiology [missing]2013-10-16
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors[1]James S. Scott, [2]Adrian L Gill, [3]Linda Godfrey, [4]Sam D Groombridge, [5]Amanda Rees, [6]John Revill, [7]Paul Schofield, [8]Pernilla Sörme, [9]Andrew Stocker, [10]John G Swales, [11]Paul R O Whittamore [Full author list]Bioorganic & Medicinal Chemistry Letters [missing]DOI: 10.1016/J.BMCL.2012.08.070 [ORCID]
PubMed: 23013933 [ORCID]
pharmacokinetics [missing]2012-09-05
Kinetic efficiency: the missing metric for enhancing compound quality?[1]Geoffrey A Holdgate, [2]Adrian L Gill [Full author list]Drug Discovery Today [missing]DOI: 10.1016/J.DRUDIS.2011.09.006 [ORCID]
PubMed: 21946261 [ORCID]
2011-09-10
A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development[1]Adrian L Gill, [2]Marcel Verdonk, [3]Robert G Boyle, [4]Richard Taylor [Full author list]Current Topics in Medicinal Chemistry [missing]DOI: 10.2174/156802607781696819 [ORCID]
PubMed: 17692029 [ORCID]
2007-01-01
The discovery of novel protein kinase inhibitors by using fragment-based high-throughput x-ray crystallography[1]Adrian Gill, [2]Anne Cleasby, [3]Harren Jhoti [Full author list]ChemBioChem [missing]DOI: 10.1002/CBIC.200400188 [ORCID]
PubMed: 15696598 [ORCID]
X-ray crystallography [missing]2005-03-01
New lead generation strategies for protein kinase inhibitors - fragment based screening approaches[1]Adrian Gill [Full author list]Mini-Reviews in Medicinal Chemistry [missing]DOI: 10.2174/1389557043487385 [ORCID]
PubMed: 15032676 [ORCID]
2004-03-01
Protein kinases in drug discovery and development.[1]Adrian Gill [Full author list]Drug Discovery Today [missing]DOI: 10.1016/S1359-6446(04)02932-0 [ORCID]
PubMed: 14761801 [ORCID]
drug discovery [missing]2004-01-01

Potential author items

NameDescriptionAuthored itemsIdentifiersEmployer(s)
A. A. GillBritish writer and critic (1954–2016)0ISNI: 0000000109622613
VIAF ID: 28804003
Slade School of Fine Art [missing]
St Christopher School [missing]
Adrian GillAustralian meteorologist (1937-1986)0ISNI: 000000008167631X
VIAF ID: 94855993
University of Cambridge [missing]
Adrian GillUS professional association football player0
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