| Title | Authors (identified) | Published In | Identifier(s) | Topic | Published Date | Match? |
|---|
| Human 3α-hydroxysteroid dehydrogenase type 3: structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth | [1]Bo Zhang, [2]Xiao-Jian Hu, [3]Xiao-Qiang Wang, [4]Jean-François Thériault, [5]Dao-Wei Zhu, [6]Peng Shang, [7]Fernand Labrie, [8]Sheng-Xiang Lin [Full author list] | Biochemical Journal [missing] | DOI: 10.1042/BCJ20160083 [ORCID]
PubMed: 26929402 [ORCID]
| | 2016-04-15 | |
| Steroid derivatives as pure antagonists of the androgen receptor | [1]Sylvain Gauthier, [2]Céline Martel, [3]Fernand Labrie [Full author list] | The Journal of Steroid Biochemistry and Molecular Biology [missing] | DOI: 10.1016/J.JSBMB.2012.02.006 [ORCID]
PubMed: 22449547 [ORCID]
| | 2012-03-23 | Fernand Labrie (Q1406512; 25 items)
|
| Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus | [1]Mahinè Ivanga, [2]Yvan Labrie, [3]Ezequiel Calvo, [4]Pascal Belleau, [5]Céline Martel, [6]Georges Pelletier, [7]Jean Morissette, [8]Fernand Labrie, [9]Francine Durocher [Full author list] | Molecular Reproduction and Development [missing] | DOI: 10.1002/MRD.20949 [ORCID]
PubMed: 18671277 [ORCID]
| | 2009-03-01 | |
| Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition | [1]Frédérick Faucher, [2]Line Cantin, [3]Van Luu-The, [4]Fernand Labrie, [5]Rock Breton [Full author list] | Biochemistry [missing] | DOI: 10.1021/BI801276H [ORCID]
PubMed: 19075558 [ORCID]
| crystal structure [missing] | 2008-12-23 | |
| The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism | [1]Frédérick Faucher, [2]Line Cantin, [3]Van Luu-The, [4]Fernand Labrie, [5]Rock Breton [Full author list] | Biochemistry [missing] | DOI: 10.1021/BI800572S [ORCID]
PubMed: 18624455 [ORCID]
| crystal structure [missing] | 2008-08-12 | |
| Androgen biosynthetic pathways in the human prostate | [1]Van Luu-The, [2]Alain Bélanger, [3]Fernand Labrie [Full author list] | Best Practice and Research: Clinical Endocrinology and Metabolism [missing] | DOI: 10.1016/J.BEEM.2008.01.008 [ORCID]
PubMed: 18471780 [ORCID]
| | 2008-04-01 | |
| Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12 | [1]Line Cantin, [2]Frédérick Faucher, [3]Jean-François Couture, [4]Karine Pereira de Jésus-Tran, [5]Pierre Legrand, [6]Liviu C Ciobanu, [7]Yvon Fréchette, [8]Richard Labrecque, [9]Shankar Mohan Singh, [10]Fernand Labrie, [11]Rock Breton [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M705524200 [ORCID]
PubMed: 17711855 [ORCID]
| ligand binding [missing] | 2007-08-21 | |
| Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding | [1]Frédérick Faucher, [2]Line Cantin, [3]Karine Pereira de Jésus-Tran, [4]Mélanie Lemieux, [5]Van Luu-The, [6]Fernand Labrie, [7]Rock Breton [Full author list] | Journal of Molecular Biology [missing] | DOI: 10.1016/J.JMB.2007.03.058 [ORCID]
PubMed: 17442338 [ORCID]
| Aldo-keto reductase family 1, member C21 [missing] | 2007-06-01 | |
| Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase | [1]Wei Qiu, [2]Ming Zhou, [3]Mausumi Mazumdar, [4]Arezki Azzi, [5]Dalila Ghanmi, [6]Van Luu-The, [7]Fernand Labrie, [8]Sheng-Xiang Lin [Full author list] | Journal of Biological Chemistry [missing] | DOI: 10.1074/JBC.M606784200 [ORCID]
PubMed: 17166832 [ORCID]
| | 2007-03-16 | |
| Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey | [1]Hong Liu, [2]Shufang Zheng, [3]Véronique Bellemare, [4]Georges Pelletier, [5]Fernand Labrie, [6]Van Luu-The [Full author list] | BMC Biochemistry [missing] | DOI: 10.1186/1471-2091-8-2 [ORCID]
PubMed: 17280614 [ORCID]
| | 2007-02-05 | |
| Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family | [1]Hong Liu, [2]Véronique Bellemare, [3]Fernand Labrie, [4]Van Luu-The [Full author list] | The Journal of Steroid Biochemistry and Molecular Biology [missing] | DOI: 10.1016/J.JSBMB.2006.10.004 [ORCID]
PubMed: 17257829 [ORCID]
| crab-eating macaque [missing] | 2007-01-25 | |
| Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme | [1]Frédérick Faucher, [2]Karine Pereira de Jésus-Tran, [3]Line Cantin, [4]Van Luu-The, [5]Fernand Labrie, [6]Rock Breton [Full author list] | Journal of Molecular Biology [missing] | DOI: 10.1016/J.JMB.2006.09.030 [ORCID]
PubMed: 17034817 [ORCID]
| crystal structure [missing]; Aldo-keto reductase family 1, member C21 [missing] | 2006-12-08 | |
| Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity | [1]Karine Pereira de Jésus-Tran, [2]Pierre-Luc Côté, [3]Line Cantin, [4]Jonathan Blanchet, [5]Fernand Labrie, [6]Rock Breton [Full author list] | Protein Science [missing] | DOI: 10.1110/PS.051905906 [ORCID]
PubMed: 16641486 [ORCID]
| crystal structure [missing]; ligand binding [missing] | 2006-05-01 | |
| Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women | [1]Fernand Labrie, [2]Alain Bélanger, [3]Patrick Bélanger, [4]René Bérubé, [5]Céline Martel, [6]Leonello Cusan, [7]José Gomez, [8]Bernard Candas, [9]Isabelle Castiel, [10]Véronique Chaussade, [11]Claire Deloche, [12]Jacques Leclaire [Full author list] | The Journal of Steroid Biochemistry and Molecular Biology [missing] | DOI: 10.1016/J.JSBMB.2006.02.004 [ORCID]
PubMed: 16621522 [ORCID]
| testosterone [missing]; testosterone [missing] | 2006-04-18 | Fernand Labrie (Q1406512; 25 items)
|
| Gonadotropin-releasing hormone agonists in the treatment of prostate cancer | [1]Fernand Labrie, [2]Alain Bélanger, [3]Van Luu-The, [4]Claude Labrie, [5]Jacques Simard, [6]Leonello Cusan, [7]José Gomez, [8]Bernard Candas [Full author list] | Endocrine Reviews [missing] | DOI: 10.1210/ER.2004-0017 [ORCID]
PubMed: 15867098 [ORCID]
| prostate cancer [missing] | 2005-05-02 | Fernand Labrie (Q1406512; 25 items)
|
| Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution. | [1]Sylvain Gauthier, [2]Julie Cloutier, [3]Yves L Dory, [4]Alexandre Favre, [5]Josée Mailhot, [6]Carl Ouellet, [7]Annette Schwerdtfeger, [8]Yves Mérand, [9]Céline Martel, [10]Jacques Simard, [11]Fernand Labrie [Full author list] | Journal of Enzyme Inhibition and Medicinal Chemistry [missing] | DOI: 10.1080/14756360500043448 [ORCID]
PubMed: 15968821 [ORCID]
| | 2005-04-01 | Fernand Labrie (Q1406512; 25 items)
|
| Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid | [1]Fernand Labrie, [2]Van Luu-The, [3]Ezequiel Calvo, [4]Céline Martel, [5]Julie Cloutier, [6]Sylvain Gauthier, [7]Pascal Belleau, [8]Jean Morissette, [9]Marie-Hélène Lévesque, [10]Claude Labrie [Full author list] | Journal of Endocrinology [missing] | DOI: 10.1677/JOE.1.05997 [ORCID]
PubMed: 15684350 [ORCID]
| | 2005-02-01 | |
| Major impact of hormonal therapy in localized prostate cancer--death can already be an exception | [1]Fernand Labrie, [2]Leonello Cusan, [3]José Gomez, [4]Van Luu-The, [5]Bernard Candas, [6]Alain Bélanger, [7]Claude Labrie [Full author list] | The Journal of Steroid Biochemistry and Molecular Biology [missing] | DOI: 10.1016/J.JSBMB.2004.10.011 [ORCID]
PubMed: 15698538 [ORCID]
| | 2004-12-21 | Fernand Labrie (Q1406512; 25 items)
|
| Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. | [1]Martine Dumont, [2]David Frank, [3]Anne-Marie Moisan, [4]Martine Tranchant, [5]Penny Soucy, [6]Rock Breton, [7]Fernand Labrie, [8]Sean V Tavtigian, [9]Jacques Simard [Full author list] | Biochimica et Biophysica Acta [missing] | DOI: 10.1016/J.BBAEXP.2004.07.001 [ORCID]
PubMed: 15358515 [ORCID]
| prostate cancer [missing] | 2004-09-01 | Fernand Labrie (Q1406512; 25 items)
|
| Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans | [1]Alain Bélanger, [2]Georges Pelletier, [3]Fernand Labrie, [4]Olivier Barbier, [5]Sarah Chouinard [Full author list] | Trends in Endocrinology and Metabolism [missing] | DOI: 10.1016/J.TEM.2003.10.005 [ORCID]
PubMed: 14643063 [ORCID]
| | 2003-12-01 | |
| Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids | [1]Jean-François Couture, [2]Pierre Legrand, [3]Line Cantin, [4]Van Luu-The, [5]Fernand Labrie, [6]Rock Breton [Full author list] | Journal of Molecular Biology [missing] | DOI: 10.1016/S0022-2836(03)00762-9 [ORCID]
PubMed: 12899831 [ORCID]
| lead [missing] | 2003-08-15 | |
| Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone | [1]Fernand Labrie, [2]Van Luu-The, [3]Claude Labrie, [4]Alain Bélanger, [5]Jacques Simard, [6]Sheng-Xiang Lin, [7]Georges Pelletier [Full author list] | Endocrine Reviews [missing] | DOI: 10.1210/ER.2001-0031 [ORCID]
PubMed: 12700178 [ORCID]
| breast cancer [missing] | 2003-04-01 | Fernand Labrie (Q1406512; 25 items)
|
| Perspective: prostate cancer susceptibility genes | [1]Jacques Simard, [2]Martine Dumont, [3]Penny Soucy, [4]Fernand Labrie [Full author list] | Endocrinology [missing] | DOI: 10.1210/EN.143.6.2029 [ORCID]
PubMed: 12021166 [ORCID]
| prostate cancer [missing] | 2002-06-01 | Fernand Labrie (Q1406512; 25 items)
|
| Crystal structure of human estrogenic 17β-hydroxysteroid dehydrogenase complexed with 17β-estradiol | [1]Arezki Azzi, [2]Peter H. Rehse, [3]D W Zhu, [4]R L Campbell, [4-Q44836742]Robert L. Campbell, [5]Fernand Labrie, [6]S X Lin, [6-Q47695864]Sheng-Xiang Lin [Full author list] | Nature Structural & Molecular Biology [missing], Nature structural biology [missing] | DOI: 10.1038/NSB0896-665 [ORCID]
PubMed: 8756321 [ORCID]
| molecular biology [missing]; crystal structure [missing]; structural biology [missing] | 1996-08-01 | |
| New Highly Stereoselective Synthesis of (Z)-4-Hydroxytamoxifen and (Z)-4-Hydroxytoremifene via McMurry Reaction | [1]Sylvain Gauthier, [2]Josée Mailhot, [3]Fernand Labrie [Full author list] | Journal of Organic Chemistry [missing] | DOI: 10.1021/JO952279L [ORCID]
PubMed: 11667248 [ORCID]
| stereoselectivity [missing] | 1996-05-01 | |