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Juan Segura-Aguilar

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Listed Publications

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50 publications found

TitleAuthors (identified)Published InIdentifier(s)TopicPublished Date
Comment on: "Activating Autophagy as a Therapeutic Strategy for Parkinson's Disease"[1]Juan Segura-Aguilar [Full author list]CNS Drugs [curation]DOI: 10.1007/S40263-018-0533-5
PubMed: 29951732		autophagy [curation]2018-07-01
Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).[1]Ana María Cárdenas, [2]Paola Fernández-Olivares, [3]Ignacio Díaz-Franulic, [4]Arlek M González-Jamett, [5]Takeshi Shimahara, [6]Juan Segura-Aguilar, [7]Raúl Caviedes, [8]Pablo Caviedes [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-017-9775-0
PubMed: 28695546		trisomy 16 [curation]2017-07-10
Aminochrome as preclinical model for Parkinson's disease[1]Juan Segura-Aguilar, [1-Q40147473]Juan Segura-Aguilar [Full author list]Oncotarget [curation]DOI: 10.18632/ONCOTARGET.18353
PubMed: 28586763		Parkinson's disease [curation]2017-06-02
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease[1]Juan Segura-Aguilar [Full author list]Neural Regeneration Research [curation]DOI: 10.4103/1673-5374.208560
PubMed: 28761417		2017-06-01
Commentary: Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?[1]Juan Segura-Aguilar, [1-Q40147473]Juan Segura-Aguilar [Full author list]Frontiers in Neuroanatomy [curation]DOI: 10.3389/FNANA.2017.00040
PubMed: 28579947		Parkinson's disease [curation]; gene therapy [curation]2017-05-19
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers[1]Patricia S Muñoz, [2]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-017-9747-4
PubMed: 28478529		autophagy [curation]; Synuclein [curation]2017-05-06
On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo[1]Andrea Herrera-Soto, [2]Gabriela Díaz-Veliz, [3]Sergio Mora, [4]Patricia Muñoz, [5]Pablo Henny, [6]Harry W M Steinbusch, [7]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-017-9719-8
PubMed: 28285345		toxic encephalopathy [curation]2017-03-11
Commentary: Evaluation of Models of Parkinson's Disease[1]Patricia Muñoz, [2]Irmgard Paris, [3]Juan Segura-Aguilar [Full author list]Frontiers in Neuroscience [curation]DOI: 10.3389/FNINS.2016.00161
PubMed: 27147953		2016-04-19
Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases[1]Silvia Costa, [2]Victor Diogenes Amaral Silva, [3]Cleide Dos Santos Souza, [4]Cleonice Creusa Santos, [5]Irmgard Paris, [6]Patricia Muñoz, [7]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-016-9600-1
PubMed: 26951456		neurodegeneration [curation]2016-03-07
The need of a new and more physiological preclinical model for Parkinson's disease[1]Juan Segura-Aguilar, [2]Irmgard Paris, [3]Patricia Muñoz [Full author list]Cellular and Molecular Life Sciences [curation]DOI: 10.1007/S00018-016-2140-2
PubMed: 26803841		Parkinson's disease [curation]2016-01-23
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)[1]Daniel J. Klionsky, [2]Kotb Abdelmohsen, [3]Akihisa Abe, [4]Md Joynal Abedin, [5]Hagai Abeliovich, [6]Abraham Acevedo-Arozena, [7]Hiroaki Adachi, [8]Christopher M Adams, [9]Peter D Adams, [10]Khosrow Adeli, ..., [1878]Per Ottar Seglen, [1879]José M Seguí-Simarro, [1880]Juan Segura-Aguilar, [1881]Ekihiro Seki, [1882]Iban Seiliez, ... [Full author list]Autophagy [curation]DOI: 10.1080/15548627.2015.1100356
PubMed: 26799652		cell biology [curation]; autophagy [curation]2016-01-02
Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease[1]Juan Segura-Aguilar, [2]Patricia Muñoz, [3]Irmgard Paris [Full author list]Current Medicinal Chemistry [curation]DOI: 10.2174/0929867323666151223094103
PubMed: 26695514		Parkinson's disease [curation]2016-01-01
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease[1]Fabio A Zucca, [2]Juan Segura-Aguilar, [3]Emanuele Ferrari, [4]Patricia Muñoz, [5]Irmgard Paris, [6]Dave Soldier, [7]Tadeusz Sarna, [8]Luigi Casella, [8-Q64779253]PATRICIA ALEJANDRA MUÑOZ SALVATIERRA, [9]Luigi Zecca [Full author list]Progress in Neurobiology [curation]DOI: 10.1016/J.PNEUROBIO.2015.09.012
PubMed: 26455458		brain [curation]; Parkinson's disease [curation]; dopamine [curation]2015-10-09
Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin[1]Andrea Briceño, [2]Patricia Muñoz, [3]Patricia Brito, [4]Sandro Huenchuguala, [5]Juan Segura-Aguilar, [6]Irmgard Paris [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-015-9560-X
PubMed: 26345577		2015-09-07
A new mechanism for protection of dopaminergic neurons mediated by astrocytes[1]Juan Segura-Aguilar [Full author list]Neural Regeneration Research [curation]DOI: 10.4103/1673-5374.162750
PubMed: 26487845		dopamine [curation]; astrocyte [curation]2015-08-01
DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity[1]Patricia Muñoz, [2]Sergio Cárdenas-García, [3]Sandro Huenchuguala, [4]Andrea Briceño, [5]Eduardo Couve, [6]Irmgard Paris, [7]Juan Segura-Aguilar [Full author list]Toxicological Sciences [curation]DOI: 10.1093/TOXSCI/KFV016
PubMed: 25634539		neurotoxicity [curation]; Synuclein [curation]2015-01-28
Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity[1]Carlos Cuevas, [2]Sandro Huenchuguala, [3]Patricia Muñoz, [4]Monica Villa, [5]Irmgard Paris, [6]Bengt Mannervik, [7]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-014-9500-1
PubMed: 25403520		glutathione [curation]; glioblastoma [curation]; neurotoxicity [curation]2014-11-18
Protective and toxic roles of dopamine in Parkinson's disease[1]Juan Segura-Aguilar, [2]Irmgard Paris, [3]Patricia Muñoz, [4]Emanuele Ferrari, [5]Luigi Zecca, [6]Fabio A Zucca [Full author list]Journal of Neurochemistry [curation]DOI: 10.1111/JNC.12686
PubMed: 24548101		Parkinson's disease [curation]; dopamine [curation]2014-03-18
Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction[1]Sandro Huenchuguala, [2]Patricia Muñoz, [3]Patricio Zavala, [4]Mónica Villa, [5]Carlos Cuevas, [6]Ulises Ahumada, [7]Rebecca Graumann, [8]Beston F Nore, [9]Eduardo Couve, [10]Bengt Mannervik, [11]Irmgard Paris, [12]Juan Segura-Aguilar [Full author list]Autophagy [curation]DOI: 10.4161/AUTO.27720
PubMed: 24434817		glutathione [curation]; glioblastoma [curation]; autophagy [curation]2014-01-14
One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity[1]Monica Villa, [2]Patricia Muñoz, [3]Ulises Ahumada-Castro, [4]Irmgard Paris, [5]Ana Jiménez, [6]Isabel Martínez, [7]Francisca Sevilla, [8]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-013-9382-7
PubMed: 23385626		neurotoxicity [curation]2013-02-06
Dopamine oxidation and autophagy[1]Patricia Muñoz, [2]Sandro Huenchuguala, [3]Irmgard Paris, [4]Juan Segura-Aguilar [Full author list]Parkinson's disease [curation]DOI: 10.1155/2012/920953
PubMed: 22966478		dopamine [curation]; autophagy [curation]2012-08-26
The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1[1]Pabla Aguirre, [2]Pamela Urrutia, [3]Victoria Tapia, [4]Monica Villa, [5]Irmgard Paris, [6]Juan Segura-Aguilar, [7]Marco T. Nunez [Full author list]BioMetals [curation]DOI: 10.1007/S10534-012-9525-Y
PubMed: 22302610		dopamine [curation]2012-08-01
Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease[1]Patricia Muñoz, [2]Sandro Huenchuguala, [3]Irmgard Paris, [4]Carlos Cuevas, [5]Monica Villa, [6]Pablo Caviedes, [7]Juan Segura-Aguilar, [8]Yousef Tizabi [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/S12640-012-9326-7
PubMed: 22528249		Parkinson's disease [curation]; substantia nigra [curation]2012-04-12
Guidelines for the use and interpretation of assays for monitoring autophagy[1]Daniel J. Klionsky, ..., [2]Fábio Camargo Abdalla, [3]Hagai Abeliovich, [4]Robert T. Abraham, [5]Abraham Acevedo-Arozena, [6]Khosrow Adeli, [7]Lotta Agholme, [8]Maria Agnello, [9]Patrizia Agostinis, [10]Julio Aguirre-Ghiso, ..., [982]Linda Sealy, [983]Per Ottar Seglen, [984]Juan Segura-Aguilar, [985]Iban Seiliez, [986]Oleksandr Seleverstov, ... [Full author list]Autophagy [curation]DOI: 10.4161/AUTO.19496
PubMed: 22966490		autophagy [curation]; selective autophagy [curation]; process utilizing autophagic mechanism [curation]2012-04-01
Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity[1]Patricia Muñoz, [2]Irmgard Paris, [3]Laurie H Sanders, [4]J. Timothy Greenamyre, [5]Juan Segura-Aguilar [Full author list]Biochimica et Biophysica Acta [curation]DOI: 10.1016/J.BBADIS.2012.03.010
PubMed: 22483869		substantia nigra [curation]; neurotoxicity [curation]; overexpression [curation]2012-03-27
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy[1]Rene L Vidal, [2]Alicia Figueroa, [3]Felipe A Court, [4]Peter Thielen, [5]Claudia Molina, [6]Craig Wirth, [7]Benjamin Caballero, [8]Roberta Kiffin, [9]Juan Segura-Aguilar, [10]Ana María Cuervo, [11]Laurie Glimcher, [12]Claudio Hetz [Full author list]Human Molecular Genetics [curation]DOI: 10.1093/HMG/DDS040
PubMed: 22337954		Huntington's disease [curation]; autophagy [curation]2012-02-14
Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line[1]Irmgard Paris, [2]Patricia Muñoz, [3]Sandro Huenchuguala, [4]Eduardo Couve, [5]Laurie H Sanders, [6]J. Timothy Greenamyre, [7]Pablo Caviedes, [8]Juan Segura-Aguilar [Full author list]Toxicological Sciences [curation]DOI: 10.1093/TOXSCI/KFR060
PubMed: 21427056		autophagy [curation]; substantia nigra [curation]; cell death [curation]2011-04-06
Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity[1]Jorge Lozano, [2]Patricia Muñoz, [3]Beston F Nore, [4]Susan Ledoux, [5]Juan Segura-Aguilar [Full author list]Chemical Research in Toxicology [curation]DOI: 10.1021/TX100182A
PubMed: 20849151		neurotoxicity [curation]2010-09-01
Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death[1]Irmgard Paris, [2]Carolina Perez-Pastene, [3]Eduardo Couve, [4]Pablo Caviedes, [5]Susan Ledoux, [6]Juan Segura-Aguilar [Full author list]Journal of Biological Chemistry [curation]DOI: 10.1074/JBC.M900323200
PubMed: 19265190		dopamine [curation]; autophagy [curation]; apoptotic process [curation]2009-03-05
Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition[1]Gabriela Díaz-Véliz, [2]Irmgard Paris, [3]Sergio Mora, [4]Rita Raisman-Vozari, [5]Juan Segura-Aguilar [Full author list]Chemical Research in Toxicology [curation]DOI: 10.1021/TX8001143
PubMed: 18500786		substantia nigra [curation]; striatum [curation]; neurotoxicity [curation]; toxic encephalopathy [curation]2008-05-23
The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism[1]Irmgard Paris, [2]Jorge Lozano, [3]Sergio Cárdenas-García, [4]Carolina Perez-Pastene, [5]Katherine Saud, [6]Patricio Fuentes, [7]Pablo Caviedes, [8]Alexies Dagnino-Subiabre, [9]Rita Raisman-Vozari, [10]Takeshi Shimahara, [11]John P Kostrzewa, [12]David Chi, [13]Richard M Kostrzewa, [14]Raul Caviedes, [15]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/BF03033505
PubMed: 18522901		dopamine [curation]; cell line [curation]2008-05-01
Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea[1]Richard M Kostrzewa, [2]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/BF03033911
PubMed: 18201955		poisoning [curation]2007-12-01
Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease[1]Irmgard Paris, [2]Sergio Cárdenas-García, [3]Jorge Lozano, [4]Carolina Perez-Pastene, [5]Rebecca Graumann, [6]Alejandra Riveros, [7]Pablo Caviedes, [8]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/BF03033921
PubMed: 17967736		Parkinson's disease [curation]; dopamine [curation]2007-09-01
Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies[1]Patricio Fuentes, [2]Irmgard Paris, [3]Melissa Nassif, [4]Pablo Caviedes, [5]Juan Segura-Aguilar [Full author list]Chemical Research in Toxicology [curation]DOI: 10.1021/TX600325U
PubMed: 17425337		substantia nigra [curation]; cell death [curation]2007-04-11
Neurotoxins and neurotoxicity mechanisms. An overview[1]Juan Segura-Aguilar, [2]Richard M Kostrzewa [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/BF03033362
PubMed: 17197375		neurotoxicity [curation]; toxic encephalopathy [curation]2006-12-01
Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome[1]Patricia Opazo, [2]Katherine Saud, [3]Michelle de Saint Pierre, [4]Ana María Cárdenas, [5]David D Allen, [6]Juan Segura-Aguilar, [7]Raúl Caviedes, [8]Pablo Caviedes [Full author list]Journal of Neuroscience Research [curation]DOI: 10.1002/JNR.21035
PubMed: 16941497		trisomy 16 [curation]2006-11-01
Dopamine-dependent iron toxicity in cells derived from rat hypothalamus[1]Irmgard Paris, [2]Pedro Martinez-Alvarado, [3]Sergio Cárdenas, [4]Carolina Perez-Pastene, [5]Rebecca Graumann, [6]Patricio Fuentes, [7]Claudio Olea-Azar, [8]Pablo Caviedes, [9]Juan Segura-Aguilar [Full author list]Chemical Research in Toxicology [curation]DOI: 10.1021/TX0497144
PubMed: 15777081		cell line [curation]2005-03-01
On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation[1]Christian Arriagada, [2]Irmgard Paris, [3]Maria Jose Sanchez de las Matas, [4]Pedro Martinez-Alvarado, [5]Sergio Cárdenas-García, [6]Patricia Castañeda, [7]Rebecca Graumann, [8]Carolina Perez-Pastene, [9]Claudio Olea-Azar, [10]Eduardo Couve, [11]Maria Trinidad Herrero, [12]Pablo Caviedes, [13]Juan Segura-Aguilar [Full author list]Neurobiology of Disease [curation]DOI: 10.1016/J.NBD.2004.03.014
PubMed: 15193303		neurotoxicity [curation]; toxic encephalopathy [curation]2004-07-01
Neurotoxins and neurotoxic species implicated in neurodegeneration[1]Juan Segura-Aguilar, [2]Richard M Kostrzewa [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/BF03033456
PubMed: 15639792		neurotoxicity [curation]2004-01-01
Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review[1]Richard M Kostrzewa, [2]Juan Segura-Aguilar [Full author list]Neurotoxicity Research [curation]DOI: 10.1007/BF03033166
PubMed: 14715440		2003-01-01
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome[1]Ana María Cárdenas, [2]David D Allen, [3]Christian Arriagada, [4]Alexis Olivares, [5]Lori B Bennett, [6]Raúl Caviedes, [7]Alexies Dagnino-Subiabre, [8]Isabel E Mendoza, [9]Juan Segura-Aguilar, [10]Stanley I. Rapoport, [11]Pablo Caviedes [Full author list]Journal of Neuroscience Research [curation]DOI: 10.1002/JNR.10205
PubMed: 11933048		trisomy 16 [curation]; cell line [curation]2002-04-01
Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival[1]Martinez-Alvarado P, [2]Alexies Dagnino-Subiabre, [3]Irmgard Paris, [4]Metodiewa D, [5]Welch CJ, [6]Olea-Azar C, [7]Caviedes P, [8]Caviedes R, [9]Juan Segura-Aguilar [Full author list]Biochemical and Biophysical Research Communications [curation]DOI: 10.1006/BBRC.2001.4907
PubMed: 11355881		cell line [curation]2001-05-01
Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line[1]Irmgard Paris, [2]Alexies Dagnino-Subiabre, [3]Marcelain K, [4]Bennett LB, [5]Caviedes P, [6]Caviedes R, [7]Azar CO, [8]Juan Segura-Aguilar [Full author list]Journal of Neurochemistry [curation]DOI: 10.1046/J.1471-4159.2001.00243.X
PubMed: 11299314		substantia nigra [curation]; neurotoxicity [curation]; toxic encephalopathy [curation]; cell line [curation]2001-04-01
Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome[1]Alexies Dagnino-Subiabre, [2]Marcelain K, [3]Arriagada C, [4]Irmgard Paris, [5]Caviedes P, [6]Caviedes R, [7]Juan Segura-Aguilar [Full author list]Molecular and Cellular Biochemistry [curation]DOI: 10.1023/A:1007129609928
PubMed: 11108144		dopamine [curation]; substantia nigra [curation]; cell line [curation]2000-09-01
Regioselectivity and reversibility of the glutathione conjugation of quercetin quinone methide[1]M G Boersma, [2]J Vervoort, [3]H Szymusiak, [4]K Lemanska, [5]Bożena Tyrakowska, [6]N Cenas, [7]Juan Segura-Aguilar, [8]Ivonne Rietjens [Full author list]Chemical Research in Toxicology [curation]DOI: 10.1021/TX990161K
PubMed: 10725115		glutathione [curation]2000-03-01
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers[1]S D Raeissi, [2]I J Hidalgo, [3]Juan Segura-Aguilar, [4]P Artursson [Full author list]Pharmaceutical Research [curation]DOI: 10.1023/A:1018851919674
PubMed: 10350002		Caco-2 [curation]1999-05-01
Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity[1]Jonas Sarlauskas, [2]E Dickancaite, [3]A Nemeikaite, [4]Z Anusevicius, [5]H Nivinskas, [6]Juan Segura-Aguilar, [7]N Cenas [Full author list]Archives of Biochemistry and Biophysics [curation]DOI: 10.1006/ABBI.1997.0285
PubMed: 9343369		1997-10-01
The Effect of 5OH-1,4-Naphthoquinone on Norway Spruce Seeds during Germination[1]Juan Segura-Aguilar, [2]I Hakman, [3]J Rydström [Full author list]Plant Physiology [curation]DOI: 10.1104/PP.100.4.1955
PubMed: 16653223		Norway [curation]1992-12-01
The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60)[1]Segura-Aguilar J, [1-Q40147473]Juan Segura-Aguilar, [2]K. Jönsson, [3]U. Tidefelt, [4]C. Paul [Full author list]Leukemia Research [curation]DOI: 10.1016/0145-2126(92)90013-W
PubMed: 1635381		oncology [curation]1992-06-01
DT-diaphorase-catalyzed two-electron reduction of quinone epoxides[1]Brunmark A, [2]Cadenas E, [3]Lind C, [4]Juan Segura-Aguilar, [5]Ernster L [Full author list]Free Radical Biology and Medicine [curation]DOI: 10.1016/0891-5849(87)90003-7
PubMed: 3117624		1987-01-01
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