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Robert Layfield

Wikidata Item | Scholia Profile [curation] | Reasonator | SQID

Listed Publications

89 publications found

TitleAuthors (identified)Published InIdentifier(s)TopicPublished Date
Adult Paget's disease of bone: a review[1]Stephen Paul Tuck, [2]Robert Layfield, [3]Julie Walker, [4]Babitha Mekkayil, [5]Roger Francis [Full author list]Rheumatology [curation]DOI: 10.1093/RHEUMATOLOGY/KEW430
PubMed: 28339664		Paget's disease of bone [curation]2017-12-01
Second-harmonic generation imaging of collagen in ancient bone[1]B Thomas, [2]David G McIntosh, [3]T Fildes, [4]L Smith, [5]F Hargrave, [6]M Islam, [7]Tim J.U. Thompson, [8]Robert Layfield, [9]D Scott, [10]B Shaw, [11]C L Burrell, [12]S Gonzalez, [13]S Taylor [Full author list]Bone reports [curation]DOI: 10.1016/J.BONR.2017.10.005
PubMed: 29124084		2017-11-01
Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours[1]Farhana Haque, [2]Pascale Varlet, [3]Julien Puntonet, [4]Lisa Storer, [5]Aikaterini Bountali, [6]Ruman Rahman, [7]Jacques Grill, [8]Angel M. Carcaboso, [9]Chris Jones, [10]Robert Layfield, [11]Richard G Grundy [Full author list]Acta Neuropathologica Communications [curation]DOI: 10.1186/S40478-017-0449-1
PubMed: 28587626		2017-06-06
Carbene footprinting accurately maps binding sites in protein-ligand and protein-protein interactions[1]Lucio Manzi, [2]Andrew S Barrow, [3]Daniel Scott, [4]Robert Layfield, [5]Timothy G Wright, [6]John E Moses, [7]Neil J Oldham [Full author list]Nature Communications [curation]DOI: 10.1038/NCOMMS13288
PubMed: 27848959		protein-protein interaction [curation]2016-11-16
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling[1]Alice Goode, [2]Sarah L. Rea, [3]Melanie Sultana, [4]Barry Shaw, [5]Mark S Searle, [6]Robert Layfield [Full author list]Molecular and Cellular Neuroscience [curation]DOI: 10.1016/J.MCN.2016.08.004
PubMed: 27554286		amyotrophic lateral sclerosis [curation]2016-08-20
Mass spectrometry insights into a tandem ubiquitin-binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin[1]Daniel Scott, [2]Tom P Garner, [3]Jed Long, [4]Jo Strachan, [5]Sharad C Mistry, [6]Andrew R. Bottrill, [7]David J Tooth, [8]Mark S Searle, [9]Neil J Oldham, [10]Robert Layfield [Full author list]Proteomics [curation]DOI: 10.1002/PMIC.201600067
PubMed: 27037516		2016-07-01
Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.[1]Alice Goode, [2]Kevin Butler, [3]Jed Long, [4]James R Cavey, [5]Daniel Scott, [6]Barry Shaw, [7]Jill Sollenberger, [8]Christopher Gell, [9]Terje Johansen, [10]Neil J Oldham, [11]Mark S. Searle, [12]Robert Layfield [Full author list]Autophagy [curation]DOI: 10.1080/15548627.2016.1170257
PubMed: 27158844		amyotrophic lateral sclerosis [curation]; autophagy [curation]2016-05-09
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)[1]Daniel J. Klionsky, [2]Kotb Abdelmohsen, [3]Akihisa Abe, [4]Md Joynal Abedin, [5]Hagai Abeliovich, [6]Abraham Acevedo-Arozena, [7]Hiroaki Adachi, [8]Christopher M Adams, [9]Peter D Adams, [10]Khosrow Adeli, ..., [1131]Helen Ka-wai Law, [1132]Kelsey B Law, [1133]Robert Layfield, [1134]Pedro A. Lazo, [1135]Laurent Le Cam, ... [Full author list]Autophagy [curation]DOI: 10.1080/15548627.2015.1100356
PubMed: 26799652		cell biology [curation]; autophagy [curation]2016-01-02
Method for the Purification of Endogenous Unanchored Polyubiquitin Chains.[1]Daniel Scott, [2]Jo Strachan, [3]Varun Gopala Krishna, [4]Barry Shaw, [5]David J Tooth, [6]Mark S Searle, [7]Neil J Oldham, [8]Robert Layfield [Full author list]Methods in Molecular Biology [curation]DOI: 10.1007/978-1-4939-3756-1_11
PubMed: 27613037		2016-01-01
Erratum[0]Antonio Facchiano, [1]Masaaki Komatsu, [2]Maria Condello, [3]Peter Vandenabeele, [4]Tobias B Huber, [5]Margarita Villar, [6]Ivanka Marković, [7]Guillermo M Albaiceta, [8]Shi-Mei Zhuang, [9]Moisés Martínez Velázquez, [10]Craig McCormick, ..., [28]Shile Huang, [29]Chih-Wen Shu, [30]Robert Layfield, [31]Guido De Meyer, [32]Simone Di Paola, ... [Full author list]Autophagy [curation]DOI: 10.1080/15548627.2016.1147886
PubMed: 26902590		Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) [curation]2016-01-01
Structural insights into interactions between ubiquitin specific protease 5 and its polyubiquitin substrates by mass spectrometry and ion mobility spectrometry[1]Daniel Scott, [2]Robert Layfield, [3]Neil J Oldham [Full author list]Protein Science [curation]DOI: 10.1002/PRO.2692
PubMed: 25970461		2015-05-29
Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.[1]Daniel Scott, [2]Robert Layfield, [3]Neil J Oldham [Full author list]Proteomics [curation]DOI: 10.1002/PMIC.201400457
PubMed: 25641936		2015-03-09
Autophagy receptor defects and ALS-FTLD[1]Veronika Majcher, [2]Alice Goode, [3]Victoria James, [4]Robert Layfield [Full author list]Molecular and Cellular Neuroscience [curation]DOI: 10.1016/J.MCN.2015.01.002
PubMed: 25683489		amyotrophic lateral sclerosis [curation]; autophagy [curation]2015-02-12
Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration[1]Gulafshana Hafeez Khan, [2]Nicolas Galazis, [3]Nikolina Docheva, [4]Robert Layfield, [5]William Atiomo [Full author list]Human Reproduction [curation]DOI: 10.1093/HUMREP/DEU268
PubMed: 25351721		pre-eclampsia [curation]; proteomics [curation]; polycystic ovary syndrome [curation]; biomarker [curation]; systematic review [curation]2015-01-01
Ubiquitin-binding domains: mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes[1]Daniel Scott, [2]Neil J Oldham, [3]Jo Strachan, [4]Mark S. Searle, [5]Robert Layfield [Full author list]Proteomics [curation]DOI: 10.1002/PMIC.201400341
PubMed: 25327553		2014-12-28
Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function[1]Alice Goode, [2]Jed A Long, [3]Barry Shaw, [4]Stuart H Ralston, [5]Micaela Rios Visconti, [6]Fernando Gianfrancesco, [7]Teresa Esposito, [8]Gennari Luigi, [9]Daniela Merlotti, [10]Domenico Rendina, [11]Sarah L. Rea, [12]Melanie Sultana, [13]Mark S. Searle, [14]Robert Layfield [Full author list]Biochimica et Biophysica Acta [curation]DOI: 10.1016/J.BBADIS.2014.03.006
PubMed: 24642144		2014-03-16
SQSTM1 mutations--bridging Paget disease of bone and ALS/FTLD[1]Sarah L. Rea, [2]Veronika Majcher, [3]Mark S. Searle, [4]Robert Layfield [Full author list]Experimental Cell Research [curation]DOI: 10.1016/J.YEXCR.2014.01.020
PubMed: 24486447		amyotrophic lateral sclerosis [curation]2014-01-30
Validation of proteomic biomarkers previously found to be differentially expressed in women with polycystic ovary syndrome: a cross-sectional study[1]Zeina Haoula, [2]Barry Shaw, [3]Clare Daykin, [4]Charlie Hodgman, [5]Robert Layfield, [6]William Atiomo [Full author list]Gynecological Endocrinology [curation]DOI: 10.3109/09513590.2013.871520
PubMed: 24397393		polycystic ovary syndrome [curation]; biomarker [curation]; polycystic ovary [curation]2014-01-07
Boning up on autophagy: the role of autophagy in skeletal biology[1]Irving M Shapiro, [2]Robert Layfield, [3]Martin Lotz, [4]Carmine Settembre, [5]Caroline Whitehouse [Full author list]Autophagy [curation]DOI: 10.4161/AUTO.26679
PubMed: 24225636		cell biology [curation]; autophagy [curation]2014-01-01
Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit[1]David Tooth, [2]Klara Garsed, [3]Gulzar Singh, [4]Luca Marciani, [5]Ching Lam, [6]Imogen Fordham, [7]Annie Fields, [8]Rawinder Banwait, [9]Melanie Lingaya, [10]Robert Layfield, [11]Maggie Hastings, [12]Peter J Whorwell, [13]Robin Spiller [Full author list]Gut [curation]DOI: 10.1136/GUTJNL-2012-304042
PubMed: 23911555		feces [curation]; diarrhea [curation]; irritable bowel syndrome [curation]2013-08-02
New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone[1]Sarah L. Rea, [2]John P. Walsh, [3]Robert Layfield, [4]Thomas Ratajczak, [5]Jiake Xu [Full author list]Endocrine Reviews [curation]DOI: 10.1210/ER.2012-1034
PubMed: 23612225		pathogenesis [curation]2013-04-23
Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration[0]Robert Layfield, [1]Nicolas Galazis, [2]Yik-Lam Pang, [3]Myria Galazi, [4]Zeina Haoula, [5]Robert Layfield, [6]William Atiomo [Full author list]Gynecological Endocrinology [curation]DOI: 10.3109/09513590.2013.777416
PubMed: 23527552		database [curation]; polycystic ovary syndrome [curation]; biomarker [curation]; endometrial cancer [curation]; systematic review [curation]; polycystic ovary [curation]2013-03-25
The S349T mutation of SQSTM1 links Keap1/Nrf2 signalling to Paget's disease of bone[1]Tao Wright, [2]Sarah L. Rea, [3]Alice Goode, [4]Andrew J Bennett, [5]Thomas Ratajczak, [6]Jed A Long, [7]Mark S. Searle, [8]Christopher E Goldring, [9]B Kevin Park, [10]Ian M Copple, [11]Robert Layfield [Full author list]Bone [curation]DOI: 10.1016/J.BONE.2012.10.023
PubMed: 23117207		2012-10-29
Cyclisation of Lys48-linked diubiquitin in vitro and in vivo[1]Kleitos Sokratous, [2]Joanna Strachan, [3]Lucy V Roach, [4]Robert Layfield, [5]Neil J Oldham [Full author list]FEBS Letters [curation]DOI: 10.1016/J.FEBSLET.2012.10.011
PubMed: 23085066		2012-10-17
Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration[1]Nicolas Galazis, [2]Olalekan Olaleye, [3]Zeina Haoula, [4]Robert Layfield, [5]William Atiomo [Full author list]Fertility and Sterility [curation]DOI: 10.1016/J.FERTNSTERT.2012.08.002
PubMed: 22959458		database [curation]; ovarian cancer [curation]; polycystic ovary syndrome [curation]; biomarker [curation]; polycystic ovary [curation]2012-09-06
Evidence for the preservation of native inter- and intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization.[1]Jonathan T S Hopper, [2]Andrew Rawlings, [3]José P Afonso, [4]Deborah Channing, [5]Robert Layfield, [6]Neil J Oldham [Full author list]Journal of the American Society for Mass Spectrometry [curation]DOI: 10.1007/S13361-012-0430-Y
PubMed: 22797884		electrospray ionization [curation]2012-07-14
Pathogenesis of Paget disease of bone[1]Stuart H Ralston, [2]Robert Layfield [Full author list]Calcified Tissue International [curation]DOI: 10.1007/S00223-012-9599-0
PubMed: 22543925		pathogenesis [curation]2012-04-29
Guidelines for the use and interpretation of assays for monitoring autophagy[1]Daniel J. Klionsky, ..., [2]Fábio Camargo Abdalla, [3]Hagai Abeliovich, [4]Robert T. Abraham, [5]Abraham Acevedo-Arozena, [6]Khosrow Adeli, [7]Lotta Agholme, [8]Maria Agnello, [9]Patrizia Agostinis, [10]Julio Aguirre-Ghiso, ..., [596]Sergio Lavandero, [597]Josée N. Lavoie, [598]Robert Layfield, [599]Pedro A. Lazo, [600]Wei-Dong Le, ... [Full author list]Autophagy [curation]DOI: 10.4161/AUTO.19496
PubMed: 22966490		autophagy [curation]; selective autophagy [curation]; process utilizing autophagic mechanism [curation]2012-04-01
Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease[1]L Chadwick, [2]L Gentle, [3]J Strachan, [4]Robert Layfield [Full author list]Neuropathology and Applied Neurobiology [curation]DOI: 10.1111/J.1365-2990.2011.01236.X
PubMed: 22082077		Alzheimer's disease [curation]2012-04-01
Structural insights into specificity and diversity in mechanisms of ubiquitin recognition by ubiquitin-binding domains[1]Mark S. Searle, [2]Thomas P Garner, [3]Joanna Strachan, [4]Jed A Long, [5]Jennifer Adlington, [6]James R Cavey, [7]Barry Shaw, [8]Robert Layfield [Full author list]Biochemical Society Transactions [curation]DOI: 10.1042/BST20110729
PubMed: 22435820		2012-04-01
Probing affinity and ubiquitin linkage selectivity of ubiquitin-binding domains using mass spectrometry[1]Kleitos Sokratous, [2]Lucy V Roach, [3]Debora Channing, [4]Joanna Strachan, [5]Jed A Long, [6]Mark S. Searle, [7]Robert Layfield, [8]Neil J Oldham [Full author list]Journal of the American Chemical Society [curation]DOI: 10.1021/JA300749D
PubMed: 22428841		2012-03-28
Insights into the molecular composition of endogenous unanchored polyubiquitin chains[1]Joanna Strachan, [2]Lucy V Roach, [3]Kleitos Sokratous, [4]David Tooth, [5]Jed A Long, [6]Thomas P Garner, [7]Mark S. Searle, [8]Neil J Oldham, [9]Robert Layfield [Full author list]Journal of Proteome Research [curation]DOI: 10.1021/PR201167N
PubMed: 22268864		2012-02-14
A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease[1]Fernando Gianfrancesco, [2]Domenico Rendina, [3]Marco Di Stefano, [4]Alessandra Mingione, [5]Teresa Esposito, [6]Daniela Merlotti, [7]Salvatore Gallone, [8]Sara Magliocca, [9]Alice Goode, [10]Daniela Formicola, [11]Giovanna Morello, [12]Robert Layfield, [13]Annalisa Frattini, [14]Gianpaolo De Filippo, [15]Ranuccio Nuti, [16]Mark S. Searle, [17]Pasquale Strazzullo, [18]Giancarlo Isaia, [19]Giuseppe Mossetti, [20]Gennari Luigi [Full author list]Journal of Bone and Mineral Research [curation]DOI: 10.1002/JBMR.542
PubMed: 21987421		2012-02-01
Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex[1]Thomas P Garner, [2]Joanna Strachan, [3]Elizabeth C Shedden, [4]Jed A Long, [5]James R Cavey, [6]Barry Shaw, [7]Robert Layfield, [8]Mark S. Searle [Full author list]Biochemistry [curation]DOI: 10.1021/BI201137E
PubMed: 21923101		2011-09-29
Induction of a stress response in Lactococcus lactis is associated with a resistance to ribosomally active antibiotics[1]James M Dorrian, [2]Deborah A Briggs, [3]Michael L Ridley, [4]Robert Layfield, [5]Ian D. Kerr [Full author list]FEBS Journal [curation]DOI: 10.1111/J.1742-4658.2011.08305.X
PubMed: 21848804		Lactococcus lactis [curation]; antibiotic resistance [curation]2011-09-15
Inhibition of cullin RING ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control[1]Boon Kim Boh, [2]Mei Ying Ng, [3]Yee Chin Leck, [4]Barry Shaw, [5]Jed A Long, [6]Guang Wen Sun, [7]Yunn Hwen Gan, [8]Mark S. Searle, [9]Robert Layfield, [10]Thilo Hagen [Full author list]Journal of Molecular Biology [curation]DOI: 10.1016/J.JMB.2011.08.030
PubMed: 21903097		2011-08-29
Impact of p62/SQSTM1 UBA domain mutations linked to Paget's disease of bone on ubiquitin recognition.[1]Thomas P Garner, [2]Jed A Long, [3]Robert Layfield, [4]Mark S. Searle [Full author list]Biochemistry [curation]DOI: 10.1021/BI200079N
PubMed: 21517082		Paget's disease of bone [curation]2011-05-09
A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.[1]Anna Daroszewska, [2]Rob J van 't Hof, [3]Javier A Rojas, [4]Robert Layfield, [5]Euphemie Landao-Basonga, [6]Lorraine Rose, [7]Ken Rose, [8]Stuart H Ralston [Full author list]Human Molecular Genetics [curation]DOI: 10.1093/HMG/DDR172
PubMed: 21515589		2011-04-21
Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones[1]Lynn Bedford, [2]Robert Layfield, [3]R John Mayer, [4]Junmin Peng, [5]Ping Xu [Full author list]Neuroscience Letters [curation]DOI: 10.1016/J.NEULET.2010.12.064
PubMed: 21215295		2011-01-05
Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway[1]Ian M Copple, [2]Adam Lister, [3]Akua D Obeng, [4]Neil R Kitteringham, [5]Rosalind Jenkins, [6]Robert Layfield, [7]Brian J Foster, [8]Christopher E Goldring, [9]B Kevin Park [Full author list]Journal of Biological Chemistry [curation]DOI: 10.1074/JBC.M109.096545
PubMed: 20378532		2010-04-08
Intracellular aggregation of human stefin B: confocal and electron microscopy study[1]Slavko Ceru, [2]Robert Layfield, [3]Tina Zavasnik-Bergant, [4]Urska Repnik, [5]Natasa Kopitar-Jerala, [6]Vito Turk, [7]Eva Zerovnik [Full author list]Biology of the Cell [curation]DOI: 10.1042/BC20090163
PubMed: 20078424		2010-03-17
Mutant p62/SQSTM1 UBA domains linked to Paget's disease of bone differ in their abilities to function as stabilization signals[1]Christian Heinen, [2]Thomas P Garner, [3]Jed A Long, [4]Claudia Böttcher, [5]Stuart H Ralston, [6]James R Cavey, [7]Mark S. Searle, [8]Robert Layfield, [9]Nico P. Dantuma [Full author list]FEBS Letters [curation]DOI: 10.1016/J.FEBSLET.2010.03.018
PubMed: 20230821		Paget's disease of bone [curation]2010-03-15
Review: the ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration[1]N Rogers, [2]S Paine, [3]L Bedford, [4]Robert Layfield [Full author list]Neuropathology and Applied Neurobiology [curation]DOI: 10.1111/J.1365-2990.2010.01063.X
PubMed: 20202119		cell death [curation]; ubiquitin-proteasome system [curation]2010-02-19
Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling[1]Jed A Long, [2]Thomas P Garner, [3]Maya J Pandya, [4]C Jeremy Craven, [5]Ping Chen, [6]Barry Shaw, [7]Michael P Williamson, [8]Robert Layfield, [9]Mark S. Searle [Full author list]Journal of Molecular Biology [curation]DOI: 10.1016/J.JMB.2009.11.032
PubMed: 19931284		NF-κB [curation]2010-02-12
Recent advances in understanding the molecular basis of Paget disease of bone[1]A Goode, [2]Robert Layfield [Full author list]Journal of Clinical Pathology [curation]DOI: 10.1136/JCP.2009.064428
PubMed: 19858527		2009-10-26
Effects of endotoxaemia on protein metabolism in rat fast-twitch skeletal muscle and myocardium[1]Andrew J Murton, [2]Nima Alamdari, [3]Sheila M Gardiner, [4]Dumitru Constantin-Teodosiu, [5]Robert Layfield, [6]Terence Bennett, [7]Paul L. Greenhaff [Full author list]PLOS One [curation]DOI: 10.1371/JOURNAL.PONE.0006945
PubMed: 19759896		2009-09-14
Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding[1]Sarah L. Rea, [2]John P. Walsh, [3]Lynley Ward, [4]Aaron L Magno, [5]Bryan K Ward, [6]Barry Shaw, [7]Robert Layfield, [8]G Neil Kent, [9]Jiake Xu, [10]Thomas Ratajczak [Full author list]Journal of Bone and Mineral Research [curation]DOI: 10.1359/JBMR.090214
PubMed: 19257822		Australia [curation]; NF-κB [curation]; Paget's disease of bone [curation]2009-07-01
Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration[1]Simon Paine, [2]Lynn Bedford, [3]Julian R Thorpe, [4]R John Mayer, [5]James R Cavey, [6]Nin Bajaj, [7]Paul W Sheppard, [8]James Lowe, [9]Robert Layfield [Full author list]Neuroscience Letters [curation]DOI: 10.1016/J.NEULET.2009.05.074
PubMed: 19500650		2009-06-07
Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis[1]Catrin S. Rutland, [2]Louise Warner, [3]Aaran Thorpe, [4]Aziza Alibhai, [5]Thelma Robinson, [6]Barry Shaw, [7]Robert Layfield, [8]J David Brook, [9]Siobhan Loughna [Full author list]Journal of Anatomy [curation]DOI: 10.1111/J.1469-7580.2009.01079.X
PubMed: 19538634		cytoskeleton [curation]2009-06-01
Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone[1]Dereen Najat, [2]Thomas Garner, [3]Thilo Hagen, [4]Barry Shaw, [5]Paul Sheppard, [6]Alberto Falchetti, [7]Francesca Marini, [8]Maria Luisa Brandi, [9]Jed A Long, [10]James R Cavey, [11]Mark S. Searle, [12]Robert Layfield [Full author list]Journal of Bone and Mineral Research [curation]DOI: 10.1359/JBMR.081204
PubMed: 19049332		2009-04-01
Proteomic biomarkers for the diagnosis and risk stratification of polycystic ovary syndrome: a systematic review[1]William Atiomo, [2]S Khalid, [3]S Parameshweran, [4]M Houda, [5]Robert Layfield [Full author list]BJOG: an International Journal of Obstetrics and Gynaecology [curation]DOI: 10.1111/J.1471-0528.2008.02041.X
PubMed: 19076945		polycystic ovary syndrome [curation]; biomarker [curation]; systematic review [curation]; polycystic ovary [curation]; diagnosis [curation]2009-01-01
The ubiquitin proteasome system in human disease[1]Robert Layfield, [2]R John Mayer [Full author list]Biochimica et Biophysica Acta [curation]DOI: 10.1016/J.BBADIS.2008.09.002
PubMed: 18845251		2008-09-18
Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies[1]Lynn Bedford, [10-Q61853326]James Lowe, [2]David Hay, [3]Anny Devoy, [4]Simon Paine, [5]Des G Powe, [6]Rashmi Seth, [7]Trevor Gray, [8]Ian Topham, [9]Kevin Fone, [10]Nooshin Rezvani, [11]Maureen Mee, [12]Tim Soane, [13]Robert Layfield, [14]Paul W Sheppard, [15]Ted Ebendal, [16]Dmitry Usoskin, [17]James Lowe, [18]R John Mayer [Full author list]Journal of Neuroscience [curation]DOI: 10.1523/JNEUROSCI.2218-08.2008
PubMed: 18701681		2008-08-01
Disruption of ubiquitin-mediated processes in diseases of the brain and bone[1]Robert Layfield, [2]Mark S. Searle [Full author list]Biochemical Society Transactions [curation]DOI: 10.1042/BST0360469
PubMed: 18481983		2008-06-01
The 6(th) East Midlands Proteomics Workshop supported by the BSPR and BMSS 14 November 2007, Nottingham, UK[1]Robert Layfield, [2]Balwir Matharoo-Ball [Full author list]Proteomics [curation]DOI: 10.1002/PMIC.200701137
PubMed: 18384108		2008-05-01
Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch[1]Jed A Long, [2]Thomas R A Gallagher, [3]James R Cavey, [4]Paul Sheppard, [5]Stuart H Ralston, [6]Robert Layfield, [7]Mark S. Searle [Full author list]Journal of Biological Chemistry [curation]DOI: 10.1074/JBC.M704973200
PubMed: 18083707		2008-02-29
Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats[1]N Alamdari, [2]Dumitru Constantin-Teodosiu, [3]A J Murton, [4]S M Gardiner, [5]T Bennett, [6]Robert Layfield, [7]Paul L. Greenhaff [Full author list]Journal of Physiology [curation]DOI: 10.1113/JPHYSIOL.2007.149625
PubMed: 18218678		lipopolysaccharide [curation]2008-01-24
Ubiquitin-mediated signalling and Paget's disease of bone[1]Robert Layfield, [2]Barry Shaw [Full author list]BMC Biochemistry [curation]DOI: 10.1186/1471-2091-8-S1-S5
PubMed: 18047742		signal transduction [curation]; Paget's disease of bone [curation]; ubiquitins [curation]2007-11-22
Assessment of the direct and indirect effects of MPP+ and dopamine on the human proteasome: implications for Parkinson's disease aetiology[1]Begoña Caneda-Ferrón, [2]Luigi A De Girolamo, [3]Teresa Costa, [4]Katy E Beck, [5]Robert Layfield, [6]E Ellen Billett [Full author list]Journal of Neurochemistry [curation]DOI: 10.1111/J.1471-4159.2007.05130.X
PubMed: 18021296		Parkinson's disease [curation]2007-11-16
The molecular pathogenesis of Paget disease of bone[1]Robert Layfield, [1-Q44287553]Robert Layfield [Full author list]Expert Reviews in Molecular Medicine [curation]DOI: 10.1017/S1462399407000464
PubMed: 17903332		2007-10-01
Characterization of biomarkers in polycystic ovary syndrome (PCOS) using multiple distinct proteomic platforms[1]Matharoo-Ball B, [2]Hughes C, [3]Lee Lancashire, [4]Tooth D, [5]Graham Ball, [6]Creaser C, [7]Elgasim M, [8]Rees R, [9]Robert Layfield, [10]William Atiomo [Full author list]Journal of Proteome Research [curation]DOI: 10.1021/PR070124B
PubMed: 17602513		polycystic ovary syndrome [curation]; biomarker [curation]; polycystic ovary [curation]2007-06-29
PPARdelta agonism induces a change in fuel metabolism and activation of an atrophy programme, but does not impair mitochondrial function in rat skeletal muscle[1]Despina Constantin, [2]Dumitru Constantin-Teodosiu, [3]Robert Layfield, [4]Kostas Tsintzas, [5]Andrew J Bennett, [6]Paul L. Greenhaff [Full author list]Journal of Physiology [curation]DOI: 10.1113/JPHYSIOL.2007.135459
PubMed: 17540700		2007-05-31
The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease[1]Phil Rolland, [2]Zahra Madjd, [3]Lindy Durrant, [4]Ian Ellis, [5]Robert Layfield, [6]Ian Spendlove [Full author list]Endocrine-Related Cancer [curation]DOI: 10.1677/ERC.1.01312
PubMed: 17395976		2007-03-01
Principles of proteomics and its applications in cancer[0]Robert Layfield, [1]S. Chuthapisith, [2]R. Layfield, [3]I.D. Kerr, [4]O. Eremin [Full author list]Journal of the Royal College of Surgeons of Edinburgh [curation]DOI: 10.1016/S1479-666X(07)80107-7
PubMed: 17313124		2007-02-01
p62 mutations, ubiquitin recognition and Paget's disease of bone[1]Robert Layfield, [2]J R Cavey, [3]Dereen Najat, [4]J Long, [5]P W Sheppard, [6]S H Ralston, [7]Mark S. Searle [Full author list]Biochemical Society Transactions [curation]DOI: 10.1042/BST0340735
PubMed: 17052185		Paget's disease of bone [curation]2006-11-01
Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone[1]J R Cavey, [2]S H Ralston, [3]P W Sheppard, [4]Barbara Ciani, [5]T R A Gallagher, [6]J E Long, [7]Mark S. Searle, [8]Robert Layfield [Full author list]Calcified Tissue International [curation]DOI: 10.1007/S00223-005-1299-6
PubMed: 16691492		2006-05-06
Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues[1]Andrew Hopkinson, [2]Richard S McIntosh, [3]Robert Layfield, [4]John Keyte, [5]Harminder S Dua, [6]Patrick J Tighe [Full author list]Proteomics [curation]DOI: 10.1002/PMIC.200401073
PubMed: 15816006		2005-05-01
Loss of Ubiquitin-Binding Associated With Paget's Disease of Bone p62 (SQSTM1) Mutations[1]James R Cavey, [2]Stuart H Ralston, [3]Lynne J Hocking, [4]Paul Sheppard, [5]Barbara Ciani, [6]Mark S. Searle, [7]Robert Layfield [Full author list]Journal of Bone and Mineral Research [curation]DOI: 10.1359/JBMR.041205
PubMed: 15765181		Paget's disease of bone [curation]2004-12-06
Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone[1]Robert Layfield, [2]Barbara Ciani, [3]S H Ralston, [4]Lynne J Hocking, [5]P W Sheppard, [6]Mark S. Searle, [7]J R Cavey [Full author list]Biochemical Society Transactions [curation]DOI: 10.1042/BST0320728
PubMed: 15493999		Paget's disease of bone [curation]2004-11-01
Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences[1]Lynne J Hocking, [2]Gavin J A Lucas, [3]Anna Daroszewska, [4]Tim Cundy, [5]Geoffrey C. Nicholson, [6]Judit Donath, [7]John P. Walsh, [8]Catriona Finlayson, [9]James R Cavey, [10]Barbara Ciani, [11]Paul Sheppard, [12]Mark S. Searle, [13]Robert Layfield, [14]Stuart H Ralston [Full author list]Journal of Bone and Mineral Research [curation]DOI: 10.1359/JBMR.0403015
PubMed: 15176995		Paget's disease of bone [curation]2004-03-22
Stability and folding kinetics of a ubiquitin mutant with a strong propensity for nonnative beta-hairpin conformation in the unfolded state[1]Geoffrey W Platt, [2]Stephen A Simpson, [3]Robert Layfield, [4]Mark S. Searle [Full author list]Biochemistry [curation]DOI: 10.1021/BI030147D
PubMed: 14622023		2003-11-01
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders[1]Robert Layfield, [2]James R Cavey, [2-Q61853326]James Lowe, [3]James Lowe [Full author list]Ageing Research Reviews [curation]DOI: 10.1016/S1568-1637(03)00025-4
PubMed: 14522239		proteolysis [curation]; neurodegeneration [curation]2003-10-01
Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone[1]Barbara Ciani, [2]Robert Layfield, [3]James R Cavey, [4]Paul Sheppard, [5]Mark S. Searle [Full author list]Journal of Biological Chemistry [curation]DOI: 10.1074/JBC.M307416200
PubMed: 12857745		Paget's disease of bone [curation]; positive regulation of transcription by RNA polymerase II [curation]; sequestosome 1 [curation]2003-09-26
Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core[1]Dmitriy Alexeev, [2]Paul N. Barlow, [3]Stella M Bury, [4]Jean-Damien Charrier, [5]Alan Cooper, [6]David Hadfield, [7]Craig Jamieson, [8]Sharon M Kelly, [9]Robert Layfield, [10]R John Mayer, [11]Helen McSparron, [12]Nicholas C Price, [13]Robert Ramage, [14]Lindsay Sawyer, [15]Bernard A Starkmann, [16]Dusan Uhrin, [17]Jill Wilken, [18]Douglas W Young [Full author list]ChemBioChem [curation]DOI: 10.1002/CBIC.200300699
PubMed: 12964166		hydrophobicity [curation]2003-09-05
Proteasomal degradation of tau protein[1]Della C. David, [2]Robert Layfield, [3]Louise Serpell, [4]Yolanda Narain, [5]Michel Goedert, [6]Maria Grazia Spillantini [Full author list]Journal of Neurochemistry [curation]DOI: 10.1046/J.1471-4159.2002.01137.X
PubMed: 12358741		2002-10-01
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome[0]Robert Layfield, [1]Tofaris GK, [2]Layfield R, [3]Spillantini MG [Full author list]FEBS Letters [curation]DOI: 10.1016/S0014-5793(01)03115-5
PubMed: 11734199		Synuclein [curation]; ubiquitin-proteasome system [curation]2001-11-01
The ubiquitin protein catabolic disorders[1]Robert Layfield, [2]A Alban, [3]R J Mayer, [4]J Lowe [Full author list]Neuropathology and Applied Neurobiology [curation]DOI: 10.1046/J.1365-2990.2001.00335.X
PubMed: 11489136		2001-06-01
Does an inhibition of the ubiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease?[1]Robert Layfield [Full author list]Medical Hypotheses [curation]DOI: 10.1054/MEHY.2000.1198
PubMed: 11359369		Alzheimer's disease [curation]2001-03-01
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease[1]Y A Lam, [2]C M Pickart, [3]A Alban, [4]Michael Landon, [5]C Jamieson, [6]R Ramage, [7]R J Mayer, [8]Robert Layfield [Full author list]Proceedings of the National Academy of Sciences of the United States of America [curation]DOI: 10.1073/PNAS.170173897
PubMed: 10944193		Alzheimer's disease [curation]; ubiquitin-proteasome system [curation]2000-08-01
Growth-promoting effects of different fractions of extra-embryonic coelomic fluid on embryonic development[1]A K Karabulut, [2]Robert Layfield, [3]M K Pratten [Full author list]Anatomia, Histologia, Embryologia [curation]DOI: 10.1046/J.1439-0264.2000.00269.X
PubMed: 11008370		2000-08-01
Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes[1]Robert Layfield, [2]Franklin K, [3]Michael Landon, [4]Walker G, [5]Wang P, [6]Ramage R, [7]Brown A, [8]Love S, [9]Urquhart K, [10]Muir T, [11]Baker R, [12]Mayer RJ [Full author list]Analytical Biochemistry [curation]DOI: 10.1006/ABIO.1999.4234
PubMed: 10527495		Ubiquitin-specific protease UBP15 YMR304W [curation]; Ubiquitin-specific protease UBP11 YKR098C [curation]1999-10-01
Selective isopeptide bond formation: coupling ubiquitin(67-76) with histone 2A(114-128) by use of the transfer active ester condensation technique[1]P Wang, [2]Robert Layfield, [3]Michael Landon, [4]R J Mayer, [5]R Ramage [Full author list]Chemical Biology and Drug Design [curation]DOI: 10.1034/J.1399-3011.1999.00075.X
PubMed: 10408342		1999-06-01
Electrophoretic separation of ubiquitin and single amino acid residue ubiquitin extensions using a commercial modified acrylamide gel electrophoresis system: an assay to determine catalytic capacities of deubiquitinating enzymes[1]Robert Layfield, [2]Hayes C, [3]Wang P, [4]Urquhart K, [5]Ramage R, [6]Mayer RJ, [7]Michael Landon [Full author list]Electrophoresis [curation]DOI: 10.1002/(SICI)1522-2683(19990301)20:3<480::AID-ELPS480>3.0.CO;2-N
PubMed: 10217157		1999-03-01
The mechanism of growth-promoting effects of prolactin in embryogenesis--links to growth factors[1]A K Karabulut, [2]Robert Layfield, [3]M K Pratten [Full author list]Cells Tissues Organs [curation]DOI: 10.1159/000016637
PubMed: 10940668		embryogenesis [curation]1999-01-01
Ubiquitin superfolds: intrinsic and attachable regulators of cellular activities?[1]Mayer RJ, [2]Michael Landon, [3]Robert Layfield [Full author list]Folding & design [curation]DOI: 10.1016/S1359-0278(98)00047-9
PubMed: 9806944		1998-01-01
Application of formalin fixation to the purification of amyloid proteins[1]Robert Layfield, [2]Bailey K, [3]Robert A. Dineen, [4]Mehrotra P, [5]Lowe J, [6]Allibone R, [7]Mayer RJ, [8]Michael Landon [Full author list]Analytical Biochemistry [curation]DOI: 10.1006/ABIO.1997.2370
PubMed: 9356158		1997-11-01
Capillary electrophoresis assay for ubiquitin carboxyl-terminal hydrolases with chemically synthesized ubiquitin-valine as substrate.[1]K Franklin, [2]Robert Layfield, [3]Michael Landon, [4]R Ramage, [5]A Brown, [6]S Love, [7]T Muir, [8]K Urquhart, [9]M Bownes, [10]R J Mayer [Full author list]Analytical Biochemistry [curation]DOI: 10.1006/ABIO.1997.2099
PubMed: 9177692		1997-05-01
Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome.[1]J Fergusson, [2]Michael Landon, [3]James Lowe, [4]S P Dawson, [5]Robert Layfield, [6]Diane P. Hanger, [7]R J Mayer [Full author list]Neuroscience Letters [curation]DOI: 10.1016/S0304-3940(96)13192-X
PubMed: 8971806		Alzheimer's disease [curation]; dementia [curation]; dementia with Lewy bodies [curation]1996-11-01
Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins[1]Robert Layfield, [2]J Fergusson, [3]A Aitken, [4]J Lowe, [5]Michael Landon, [6]R J Mayer, [6-Q61853326]James Lowe [Full author list]Neuroscience Letters [curation]DOI: 10.1016/0304-3940(96)12598-2
PubMed: 8734909		Alzheimer's disease [curation]1996-05-01
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